DOI QR코드

DOI QR Code

상황버섯 균사체로 발효한 다시마 추출물의 항산화 활성

Fermented Saccharina japonica with Phellinus linteus Mycelia Enhances its Radical Scavenging Activities

  • Kim, Yon-Suk (Department of Biotechnology, Konkuk University) ;
  • Park, Pyo-Jam (Department of Biotechnology, Konkuk University) ;
  • Jeong, Jae-Hyun (Department of Food Science and Technology, Korea National University of Transportation)
  • 투고 : 2017.08.14
  • 심사 : 2017.08.19
  • 발행 : 2017.08.31

초록

To develop new functional materials, Saccharina japonica (S. japonica) was cultivated with Phellinus linteus (P. linteus) mycelia by solid culture. S. japonica was fermented with P. linteus mycelia. The various radical scavenging activities of extracts of fermented S. japonica with P. linteus mycelia (FSPM) were investigated and compared to the antioxidant capabilities of unfermented S. japonica and P. linteus mycelia. The antioxidant activities of FSPM extracts were evaluated using ferric reducing antioxidant power (FRAP) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. FSPM showed stronger free radical scavenging abilities than P. linteus mycelia or S. japonica alone. These results indicate that fermentation of S. japonica changes its chemical nature and could provide beneficial antioxidant effects.

키워드

참고문헌

  1. Chen W, Feng L, Huang, Z and Su H. 2012. Hispidin produced from Phellinus linteus protects against peroxynitritemediated DNA damage and hydroxyl radical generation. Chem Biol Interact 199, 137-142. https://doi.org/10.1016/j.cbi.2012.07.001.
  2. Chen W, Shen Y, Su H and Zheng X. 2014. Hispidin derived from Phellinus linteus affords protection against acrylamideinduced oxidative stress in Caco-2 cells. Chem Biol Interact 219, 83-89. https://doi.org/10.1016/j.cbi.2014.05.010.
  3. Eshwarappa RS, Iyer S, Subaramaihha SR, Richard SA and Dhananjaya BL. 2015. Antioxidant activities of ficus glomerata (moraceae) leaf gall extracts. Pharmacognosy Res 7, 114-120. https://doi.org/10.4103/0974-8490.147225.
  4. Hsieh MJ, Chien SY, Chou YE, Chen CJ, Chen J and Chen MK. 2014. Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway. Phytomedicine 21, 1746-1752. https://doi.org/10.1016/j.phymed.2016.12.012.
  5. Huang HY, Chieh SY, Tso TK, Chien TY, Lin HT and Tsai YC. 2011. Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cellbearing mice. J Ethnopharmacol 133, 460-466. https://doi.org/10.1016/j.jep.2010.10.015.
  6. Jin W, Zhang W, Wang J and Zhang Q. 2013. The neuroprotective activities and antioxidant activities of the polysaccharides from Saccharina japonica. Int J Biol Macromol 58, 240-244. https://doi.org/10.1016/j.ijbiomac.2013.04.009.
  7. Kim MK, Kim IH and Nam TJ.2014. Saccharina japonica extract protects against carbon tetrachloride-induced hepatotoxicity in rats. Korean J Fish Aquat Sci 47, 204-210. http://doi.org/10.5657/KFAS.2014.0204.
  8. Kim SH, Song YS, Kim SK, Kim BC, Lim CJ and Park EH. 2004. Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus. J Ethnopharmacol 93, 141-146. http://doi.org/10.1016/j.jep.2004.03.048.
  9. Kim YS, Lee SJ, Hwang JW, Kim EK, Kim SE, Kim EH, Moon SH, Jeon BT and Park PJ. 2012. In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. Food Chem Toxicol 50, 4191-4198. http://doi.org/10.1016/j.fct.2012.08.015.
  10. Koo JG, Jo KS, Do JR and Woo SJ. 1995. Isolation and purification of fucoidans from Laminaria religiosa and Undaria pinnatifida in Korea. J Korean Fish Soc 28, 227-236.
  11. Lee YS, Kang YH, Jung JY, Kang IJ, Han SN, Chung JS, Shin HK and Lim SS. 2008. Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm Bull 31, 765-768. http://doi.org/10.1248/bpb.31.765.
  12. Limon RI, Penas E, Torino MI, Martinez-Villaluenga C, Duenas M and Frias J. 2015. Fermentation enhances the content of bioactive compounds in kidney bean extracts. Food Chem 172, 343-352. http://doi.org/10.1016/j.foodchem.2014.09.084.
  13. Nagatsu A, Itoh S, Tanaka R, Kato S, Haruna M, Kishimoto K, Hirayama H, Goda Y, Mizukami H and Ogihara Y. 2004. Identification of novel substituted fused aromatic compounds, meshimakobnol A and B, from natural Phellinus linteus fruit body. Tetrahedron Lett 45, 5931-5933. http://doi.org/10.1002/chin.200446210.
  14. Nanjo F, Goto K, Seto R, Suzuki M, Sakai M and Hara Y. 1996. Scavenging effects of tea catechins and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical. Free Radic Biol Med 21, 895-902. https://doi.org/10.1016/0891-5849(96)00237-7.
  15. Olugbami JO, Gbadegesin MA and Odunola OA. 2015. In vitro free radical scavenging and antioxidant properties of ethanol extract of Terminalia glaucescens. Pharmacognosy Res 7, 49-56. http://doi.org/10.4103/0974-8490.147200.
  16. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M and Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26, 1231-1237. https://doi.org/10.1016/S0891-5849(98)00315-3.
  17. Reis FS, Barreira JCM, Calhelha RC, van Griensven LJID, Ciric A, Glamoclija, J, Sokovic M and Ferreira ICFR. 2014. Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity. LWT Food Sci Technol 58, 478-485. https://doi.org/10.1016/j.lwt.2014.04.013.
  18. Ruperez P, Ahrazem O and Leal JA. 2002. Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem 50, 840-5. https://doi.org/10.1021/jf010908o.
  19. Salimikia I, Yazdinezhad AR, Golfakhrabadi F and Esfahani HR. 2015. In vitro antioxidant and free radical scavenging activity of four Alkanna species growing in Iran. Pharmacognosy Res 7, 100-104. https://doi.org/10.4103/0974-8490.147218.
  20. Sugai-Guerios MH, Balmant W, Furigo A Jr, Krieger N and Mitchell DA. 2015. Modeling the Growth of Filamentous fungi at the Particle Scale in solid-state fermentation systems. Adv Biochem Eng Biotechnol 149, 171-221. https://doi.org/10.1007/10_2014_299.
  21. Torino MI, Limon RI, Martinez-Villaluenga C, Makinen S, Pihlanto A, Vidal-Valverde C and Frias J. 2013. Antioxidant and antihypertensive properties of liquid and solid state fermented lentils. Food Chem 136, 1030-1037. https://doi.org/10.1016/j.foodchem.2012.09.015.
  22. Vishchuk OS, Ermakova SP and Zvyagintseva TN. 2011. Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity. Carbohydr Res 346, 2769-2776. https://doi.org/10.1016/j.carres.2011. 09.034.
  23. Wang J, Zhang Q, Zhang Z and Li Z. 2008. Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol 42, 127-132. https://doi.org/ 10.1016/j.ijbiomac.2007.10.003.
  24. Wang ZB, Pei JJ, Ma HL, Cai PF and Yan JK. 2014. Effect of extraction media on preliminary characterizations and antioxidant activities of Phellinus linteus polysaccharides. Carbohydr Polym 109, 49-55. https://doi.org/10.1016/j.carbpol.2014.03.057.
  25. Wu SJ, Liaw CC, Pan SZ, Yang HC and Ng LT. 2013. Phellinus linteus polysaccharides and their immunomodulatory properties in human monocytic cells. J Functional Foods 5, 679-688. https://doi.org/10.1016/j.jff.2013.01.011.
  26. Yoon YD, Lee ES, Park JP, Lim MR, Lee JW, Kim TH, Na MK and Kim JH. 2011. Immunostimulatory effect by aqueous extract of Hizika fusiforme in RAW264.7 marcrophage and whole spleen cells. Biotechnol Bioproce 16, 1099-1105. https://doi.org/10.1007/s12257-011-0177-5.