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Correlation Relationship between Personal Exposure and Biological Monitoring for Airborne Toluene in an Industrial Complex and General Environments

산업단지 및 일반생활 지역의 공기 중 톨루엔에 대한 개인노출 및 생체시료의 상관성 분석

  • Lee, Byoungjun (Department of Occupational Health, Daegu Catholic University) ;
  • Heo, Jung (Department of Occupational Health, Daegu Catholic University) ;
  • Jung, Dayoung (Department of Occupational Health, Daegu Catholic University) ;
  • Kim, Sunshin (Environmental Health Center for Hazardous Gas Exposure, Gumi Hospital, Soonchunhyang University College of Medicine) ;
  • Ryu, Hyeon-Su (Department of Occupational Health, Daegu Catholic University) ;
  • Choi, Min-Ji (Department of Occupational Health, Daegu Catholic University) ;
  • Shuai, Jian-Fei (Department of Occupational Health, Daegu Catholic University) ;
  • Im, Sung-Guk (Institute of Occupational and Environmental Health, Korean Industrial Health Association) ;
  • Yang, Wonho (Department of Occupational Health, Daegu Catholic University)
  • 이병준 (대구가톨릭대학교 산업보건학과) ;
  • 허정 (대구가톨릭대학교 산업보건학과) ;
  • 정다영 (대구가톨릭대학교 산업보건학과) ;
  • 김순신 (순천향대학교 구미병원 유해가스노출 환경보건센터) ;
  • 류현수 (대구가톨릭대학교 산업보건학과) ;
  • 최민지 (대구가톨릭대학교 산업보건학과) ;
  • 솨이지엔페이 (대구가톨릭대학교 산업보건학과) ;
  • 임성국 (대한산업보건협회 산업보건환경연구원) ;
  • 양원호 (대구가톨릭대학교 산업보건학과)
  • Received : 2017.08.01
  • Accepted : 2017.08.04
  • Published : 2017.08.28

Abstract

Objectives: The purpose of this study was to assess the correlation relationship between personal exposure and urinary hippuric acid in biological monitoring for airborne toluene in an industrial complex and in general environments. Methods: Personal exposure to toluene and its metabolite, hippuric acid, in urine were simultaneously measured in occupational environments area near an industrial complex and in general environments. The study subjects were divided into three types: 137 workers who use organic solvents in the workplace, 210 residents living near a dyeing industrial complex, and 379 residents living in general environments. The toluene exposures of workers and residents were measured by a passive sampler for four days. The urine of participants was sampled when the passive samplers of personal exposure were collected. Results: The toluene and hippuric acid concentrations of workers were the highest, followed by the concentrations of residents living near a dyeing industrial complex and residents living in general environments. The coefficient of correlation between the concentrations of toluene and hippuric acid among workers was 0.749 (p<0.01) in the workplace. On the contrary, correlations between the concentrations of toluene and hippuric acid among residents living near a dyeing industrial complex and residents living in general environments were all not significant. The relationship between the concentrations of hippuric acid and toluene in three types could be described by the exponential growth model. Conclusions: This study analyzed the relationships between toluene exposure and the concentrations of hippuric acid in urine in high, middle, and low exposure environments, and could be described by the exponential growth model.

Keywords

References

  1. Lee H, Moon K, Ahn K, Suh J. Health impairment and concentration of hippuric acid in urine of workers exposed to toluene. Journal of the Environmental Sciences. 2004; 13(10): 939-946. https://doi.org/10.5322/JES.2004.13.10.939
  2. Cha S, Yoon C, Lee S. Effect of hepatic damage on the toluene metabolism in carbon tetrachloride pretreated- rats. Journal Toxicology and Public Health. 1998; 14(3): 321-328.
  3. National Institute of Environmental Research. A study on preparation of national priority material management Plan(?), 2011.
  4. Cohr, K.H, Stokholm, J. Toluene: A toxicologic review. Scandinavian Journal of Work. Environment & Health. 1979; 5(2): 71-90. https://doi.org/10.5271/sjweh.2664
  5. Sarma, S.N, Kim, Y, Song, M, Ryu, J. Induction of apoptosis in human leukemia cells through the production of reactive oxygen species and activation of HMOX1 and Noxa by benzene, toluene, and oxylene. Toxicology. 2011; 280(3): 109-117. https://doi.org/10.1016/j.tox.2010.11.017
  6. United States Environmental Protection Agency (US EPA). Exposure factors handbook, Volume 1- General factors. Environmental Protection Agency. 1997; EPA/600/P-95/002Fa.
  7. Maroni, M, A, Fait, C. Colosio. Risk assessment and management of occupational exposure to pesticides. Toxicology Letters. 1999; 107(1): 145-153. https://doi.org/10.1016/S0378-4274(99)00041-7
  8. Li, Z, Mulholland, A, Romanoff, C, Pittman, N, Trinidad, A, Lewinc, D, Sjodin, A. Assessment of non-occupational exposure to polycyclic aromatic hydrocarbons through personal air sampling and urinary biomonitoring. Journal of Environmental Monitoring. 2010; 12(5): 1110-1118. https://doi.org/10.1039/c000689k
  9. National Institute of Environmental Research. A pilot study on the time-activity pattern for exposure pathway of hazardous pollutants (I), 2013.
  10. Manini, P, G. De Palma, A. Mutti. Exposure assessment at the workplace: implications of biological variability. Toxicology letters. 2007; 168: 210-218. https://doi.org/10.1016/j.toxlet.2006.09.014
  11. Lee G, Shin T, Hong S, Kim K. Correlation of urinary hippuric acid concentration according to occupational exposure level of toluene and worker's characteristics. Journal of Environmental Impact Assessment. 2015; 24(2): 154-162. https://doi.org/10.14249/eia.2015.24.2.154
  12. Lee S, Ahn K, Lee B, Nam T. A Study on Relationship between exposure to toluene and excretion of hippuric acid in urine with male solvent workers. Journal of Preventive Medicine and Public Health. 1989; 22(4): 480-485 .
  13. Chang S. A study on the correlation of ambient toluene and xylene with biological monitoring index. Annals of Occupational and Environmental Medicine. 1995; 7(2): 295-305.
  14. Kim YH, Yang WH, Son BS. Risk assessment by toluene source emission model in indoor environments of new houses. Journal of the Korean Environmental Sciences Society. 2006; 32(5): 398-403.
  15. Hwang C, Lee W, Chang S, Kim H. The relationship between hippuric acid in blood plasma and toluene concentration in the air of workplace. Journal of Preventive Medicine and Public Health. 2000; 33(1): 45-50.
  16. Lee C, Choi S, Hong S, Chung E, Jung Y, Yang W, Lee J, Son B. Health risk assessment and VOCs levels of residents in industrial area. Journal of the Korean Environmental Sciences Society. 2011; 20(11): 1373-1382.
  17. Lee D, Park K, Kim T, Shin D, Shin S. Offsite risk assessment on flammable hazard site. Korean Journal of Hazardous Materials. 2015; 3(1): 52-58.
  18. Sahri, M, Widajati, N. Evaluation of toluene exposure in workers at industrial area of sidoarjo. Indonesia by measurement of urinary hippuric acid. Asia Pacific Journal of Medical Toxicology. 2013; 2(4): 145-149.
  19. Cok, I, Dagdelen, A, Gokce, E. Determination of urinary hippuric acid and o-cresol levels as biological indicators of toluene exposure in shoe-workers and glue sniffers. Biomarkers. 2003; 8(2): 119-127. https://doi.org/10.1080/1354750031000119398
  20. Fustinoni, S, Buratti, M, Giampiccolo, R, Brambilla, G, Foa, V, Colombi, A. Comparison between blood and urinary toluene as biomarkers of exposure to toluene. International archives of occupational and environmental health. 2000; 73(6): 389-396. https://doi.org/10.1007/s004200000156
  21. Konjin, Z. N, Azari, M. R, Shekoohi, Y, Rahimzadeh, M, Seyedi, M. Efficacy of urinary hippuric acid as a biomarker of low level exposure to toluene in petroleum depot workers. International Journal of Occupational Hygiene. 2013; 5(3): 139-143.
  22. Yoon Y, Jo Y. Prediction of failure time of tunnel applying the curve fitting techniques. Tunnel And Underground Space. 2010; 20(2): 97-104.
  23. Chung S. Yun T, Han T. Usability Evaluation of RVE using exponential curve fitting. Korean Society of Civil Engineers. 2010; 10: 1184-1188.
  24. Duydu, Y, Suzen, S, Erdem, N, Uysal, H, Vural, N. Validation of hippuric acid as a biomarker of toluene exposure. Bulletin of environmental contamination and toxicology. 1999; 63(1): 1-8. https://doi.org/10.1007/s001289900940
  25. Ldeira, C, Viegas S. Human biomonitoring - An overview on biomarkers and their application in occupational and environmental health. Biomonitoring. 2016; 3: 15-24.
  26. Denneman, E, Wu, R, Kearsleyb, E, Visserb, A. Discrete fracture in high performance fibre reinforced concrete materials. Engineering Fracture Mechanics. 2011; 78(10): 2235-2245. https://doi.org/10.1016/j.engfracmech.2011.04.008