Journal of Hospice and Palliative Care

Korean Society for Hospice and Palliative Care (한국호스피스완화의료학회)
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Symptom Features of Terminally Ill Cancer Patients and Depression of Family Caregivers

  • Received : 2017.05.25
  • Accepted : 2017.07.19
  • Published : 2017.09.01
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Abstract

Purpose: There has been very little study on the associations between patient's symptoms themselves and family caregiver (FC)'s depression in the palliative phase. This cross-sectional study was to investigate the relationship between symptom features of terminally ill cancer patients and their FC's depression. Methods: We performed a multicenter survey using the MD Anderson symptom inventory and the Hospital Anxiety and Depression Scale. A total of 293 patient-FC pairs were recruited from seven tertiary medical centers. A multivariate regression analysis was applied for identifying the relevant factors associated with FC depression and for estimating adjusted depression score of FCs. Results: Among various psychosocial factors, low FC quality of life, low social support, spouse, and more caregiving time were significantly associated with FCs' depression. According to the presence of FCs' depression, there were significant differences in some symptom characteristics of patients. Even after adjusting for the relevant confounders, depression scores were lower in FCs caring for patients who had negative symptoms (loss of appetite, P=0.005; drowsiness, P=0.024; and dry mouth, P=0.043) than in FCs caring for patients who had not. FCs caring for patients with severe appetite loss had lower depression scores than those with not severe one (P=0.039). Conclusion: Our result suggests that patient's symptom characteristics might be helpful when evaluating a FC's depression.

목적: 완화적 시기에 말기 암환자의 증상과 가족간병인의 우울 간의 관계에 대한 연구는 매우 드물다. 본 단면연구에서는 말기 암환자의 증상특징과 그들의 가족간병인의 우울 간의 관계에 대해 살펴보고자 하였다. 방법: MD Anderson Symptom Inventory와 Hospital Anxiety and Depression Scale을 이용한 다기관 조사연구가 진행되었다. 총 293쌍의 말기 암환자와 가족간병인이 7개 기관에서 등록되었다. 가족간병인의 우울과 관련된 요인을 추출하고, 보정된 우울점수를 추정하기 위해 다변량 회귀분석이 사용되었다. 결과: 다양한 심리사회적 요인들 중, 가족간병인의 낮은 삶의 질, 낮은 사회적 지지, 배우자 관계, 그리고 더 많은 간병시간 등이 가족간병인의 우울과 유의한 관련성을 보였다. 가족 간병인의 우울여부에 따라, 환자의 몇 가지 증상에서 유의한 차이가 관찰되었다. 관련된 혼란변수를 보정한 이후에도, 음성증상이 없는 환자를 돌보고 있는 가족간병인보다 음성증상을 가진 환자를 돌보고 있는 가족간병인에서 우울점수가 유의하게 낮았다(식욕소실, P=0.005; 졸음, P=0.024; 그리고 입마름, P=0.043). 중증의 식욕소실을 가진 환자를 돌보고 있는 가족간병인의 우울점수는 비중증의 식욕소실을 가진 환자를 돌보고 있는 가족간병인의 우울점수보다 낮았다(P=0.039). 결론: 본 연구결과는 가족간병인의 우울을 평가할 때 환자의 증상 특징이 도움이 될 수 있음을 시사한다.

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