Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effects of Adenophora triphylla var. japonica Extract on Cognitive Function in Ovariectomized Mice

난소절제 마우스에서 잔대 추출물의 인지능 개선 효과

  • Jang, Hwan Hee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Sciences, RDA) ;
  • Kim, Haeng Ran (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Sciences, RDA) ;
  • Lee, Young Min (Major of Food and Nutrition, Division of Applied Food System, Seoul Women's University,)
  • 장환희 (국립농업과학원 기능성식품과) ;
  • 김행란 (국립농업과학원 기능성식품과) ;
  • 이영민 (서울여자대학교 식품영양학과)
  • Received : 2017.05.15
  • Accepted : 2017.08.17
  • Published : 2017.08.31
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Abstract

Adenophora triphylla var. japonica extract has been reported to have estrogenic activity and beneficial effects in postmenopausal women requiring estrogen replacement therapy. This study investigated the effects of A. triphylla extract on cognitive function in ovariectomized mice. Water extracts from A. triphylla were administrated to ovariectomized mice fed a high fat diet for 6 weeks. The step through latency time in the passive avoidance test was shortened in ovariectomized mice as compared with sham-operated mice. However, administration of A. triphylla extracts had a tendency to prolong the latency time in ovariectomized mice. Moreover, A. triphylla supplementation caused a significant decrease in mean escape latency in the water maze test. These results indicate that A. triphylla could be used to improve estrogen deficiency-related learning and memory impairments in postmenopausal women.

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References

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