KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Antimelanogenic of Artemisia fukudo Makino Extract in Melanoma Cells

큰비쑥 추출물의 멜라닌 생성 억제 효과

  • Kim, Min-Jin (Nakdonggang National Institute of Biological Resources) ;
  • Kim, Seoyeon (Department of Chemistry and Cosmetics, Jeju National University) ;
  • Hyun, Kwang Hee (Helios) ;
  • Kim, Duk Soo (Department of Chemistry and Cosmetics, Jeju National University) ;
  • Kim, Seung-Young (Department of BT Convergent Pharmaceutical Engineering, Sunmoon University) ;
  • Hyun, Chang-Gu (Department of Chemistry and Cosmetics, Jeju National University)
  • 김민진 (국립낙동강생물자원관) ;
  • 김서연 (제주대학교 화학코스메틱스학과) ;
  • 현광희 (헬리오스) ;
  • 김덕수 (제주대학교 화학코스메틱스학과) ;
  • 김승영 (선문대학교 BT융합제약공학과) ;
  • 현창구 (제주대학교 화학코스메틱스학과)
  • Received : 2017.07.21
  • Accepted : 2017.08.04
  • Published : 2017.09.30
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Abstract

Melanin is one of the most important factors affecting skin color. Melanogenesis is the bioprocess of melanin production by melanocytes in the skin and hair follicles and is mediated by several enzymes, such as tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2, MITF. In this study, we investigated the effect of Artemisia fukudo Makino extracts on tyrosinase activity and melanin production as natural products of whitening functional cosmetics. Melanin content in murine B16F10 melanoma cells were decreased by Artemisia fukudo Makino extracts in a dose-dependently. In addition, the inhibition of tyrosinase activity of Artemisia fukudo Makino extracts showed to decrease tyrosinase activity as the concentration of ${\alpha}-MSH$ was increased. Furthermore, western blot analysis revealed that Artemisia fukudo Makino extracts significantly downregulated the expression of tyrosinase, TRP-1 which treat of ${\alpha}-MSH-induced$ melanogenesis in murine B16F10 melanoma cells. As a result, Artemisia fukudo Makino extract showed functionalities as an effective whitening agent to inhibit melanin formation.

Keywords

Acknowledgement

Supported by : 한국연구재단

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