Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A Review on Experimental Research about Anticancer Drug Combined Treatment with Herbal Medicine for Killing or Inhibiting Proliferation of Cancer cells in Korea.

항암제와 한약재의 병용투여 시 암세포 증식억제 효과에 대한 국내 실험연구 문헌고찰

  • Lee, Ji Eun (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Choi, Jin Yong (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Han, Chang Woo (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Choi, Jun Yong (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Park, Seong Ha (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Kim, So Yeon (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
  • 이지은 (부산대학교 한의학전문대학원 한의학과) ;
  • 최진용 (부산대학교 한의학전문대학원 한의학과) ;
  • 한창우 (부산대학교 한의학전문대학원 한의학과) ;
  • 최준용 (부산대학교 한의학전문대학원 한의학과) ;
  • 박성하 (부산대학교 한의학전문대학원 한의학과) ;
  • 김소연 (부산대학교 한의학전문대학원 한의학과)
  • Received : 2017.08.09
  • Accepted : 2017.08.29
  • Published : 2017.08.31
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Abstract

Objective : In this study, we searched the experimental research about combined treatment of anticancer drug and herbal medicine for killing or inhibiting proliferation of Cancer cells searched in OASIS and KISS. This study aimed to analyze the experimental research paper about anticancer drug combined treatment with herbal medicine. Methods : We collected the research paper including killing or inhibiting proliferation of Cancer cells in OASIS and KISS using keyword anticancer drug with herbal medicine, tumor suppressor with herbal medicine, inhibition of Cancer with herbal medicine and combined treatment with herbal medicine. Assorting by cancer cells, we analyzed experimental results cancer cell viability, anticancer drug dosage, tumor weight and survival rate. Also, we checked the effects of herbal medicine on cancer and additive effect reducing side effect of anticancer drug. Results : Total 45 studies were selected. 38 studies reported combined treatment of anticancer drug and herbal medicine was more effective than only anticancer drug. The death of cancer cells was synergistically induced by the cotreatment of anticancer drug and herb extracts. The studies suggest that the cotreatment of anticancer drug and herb extracts could reduce side effect of anticancer drug. In addition, some studies reported cotreatment mechanism like apoptotic death signal processes. In combined treatment of anticancer drug and herb extracts, The expression of Fas/Fas L, Bax, Bcl2, Caspase-3 etc.. was markedly increased in cancer cells. Conclusions : Our results suggest that anticancer drug combined treatment with herbal medicine could be efficient for killing or inhibiting proliferation of cancer cells. However, this paper had some limitation as follows: First, collected studies have been published only for korean journal. Second, results of research and effects of combined treatment are not collected objectively. To solve these problems, more objective and balanced studies should be performed.

Keywords

References

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