Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory and Antioxidant Effects of Clam Worm Extract Treated with Peptidoglycan

펩티도글리칸 처리된 갯지렁이 추출물의 항염증 및 항산화 효과

  • Kim, Se-woong (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University) ;
  • Sapkota, Mahesh (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University) ;
  • Yang, Ming (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University) ;
  • Li, Liang (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University) ;
  • Soh, Yunjo (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
  • 김세웅 (전북대학교 치과대학 치과약리학교실) ;
  • 삽코타마헤쉬 (전북대학교 치과대학 치과약리학교실) ;
  • 양명 (전북대학교 치과대학 치과약리학교실) ;
  • 이양 (전북대학교 치과대학 치과약리학교실) ;
  • 소윤조 (전북대학교 치과대학 치과약리학교실)
  • Received : 2017.07.21
  • Accepted : 2017.09.05
  • Published : 2017.09.30
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Abstract

Peptidoglycan in inserts and mammals is well known to improve biological functions in the host's immune system. However, it is unclear how Peptidoglycan exerted its anti-inflammatory capacity especially in clam worm (Marphysa sanguinea). In this experiment, the anti-inflammatory and antioxidant effects of clam worm extract treated with (PCWE) peptidoglycan (Micrococcus luteus) in RAW264.7 cells were examined by measuring MDA, catalase, SOD, GSH-Px and inflammatory cytokines (nitric oxide, iNOS, interleukin-$1{\beta}$ and tumor necrosis factor-${\alpha}$). PCWE significantly increased the activities of catalase, SOD and GSH-Px and decreased the level of MDA. Interestingly, PCWE induced activities of SOD and GSH-Px more than clam worm extract without peptidoglycan (CWE). In addition, PCWE decreased NO production, iNOS, COX-2, TNF-${\alpha}$ and IL-$1{\beta}$ better than CWE. Taken together, these results indicate that PCWE has the potential as a natural antioxidant and a therapeutic for inflammation-related diseases.

Keywords

References

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