대한의생명과학회지 (Biomedical Science Letters)

  • 제23권3호
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  • Pages.201-207
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  • 2017
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

  • Sull, Jae Woong (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University) ;
  • Koh, Eun Na (Exercise Medicine Center for Diabetes and Cancer Patients, Yonsei University) ;
  • Cho, Sung Kweon (Department of Pharmacology, Yonsei University College of Medicine) ;
  • Bae, Hyung-Joon (Department of Clinical Laboratory Science, Daejeon Institute of Science and Technology) ;
  • Jee, Sun Ha (Institute for Health Promotion & Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University)
  • 투고 : 2017.07.23
  • 심사 : 2017.09.12
  • 발행 : 2017.09.30
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초록

Measuring the pulse wave velocity (PWV) is a non-invasive method for evaluating the stiffness of the vessel wall. While previous studies investigated the association of uric acid level with arterial stiffness, most did not consider smoking status and obesity as covariates. The objective of this study was to investigate the relationship between uric acid levels and arterial stiffness, considering smoking status and obesity. We studied 3390 subjects (1940 males and 1450 females). Abnormal PWV was also defined as the highest quartile of values in the subjects. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Approximately 41.9% of men and 3.7% of women were current smokers. Prevalence of hypertension was 11.4% in men and 7.0% in women. In women, hyperuricemia was associated with abnormal PWV (OR 1.58; 95% CI 1.03~2.43). Hyperuricemia was also associated with abnormal PWV (OR 2.37; 95% CI 1.01~5.59) in non- or light male smokers with normal blood pressure. This study suggests that uric acid is associated with arterial stiffness in women and non-smoking men.

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참고문헌

  1. Bae JS, Shin DH, Park PS, Choi BY, Kim MK, Shin MH, Lee YH, Chun BY, Kim SK. The impact of serum uric acid level on arterial stiffness and carotid atherosclerosis: The Korean Multi-Rural Communities Cohort study. Atherosclerosis. 2013. 231:145-151. https://doi.org/10.1016/j.atherosclerosis.2013.08.017
  2. Chen X, Li Y, Sheng CS, Huang QF, Zheng Y, Wang JG. Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting. American Journal of Hypertension. 2010. 23: 387-392. https://doi.org/10.1038/ajh.2009.277
  3. Cohn JN. Vascular wall function as a risk marker for cardiovascular disease. Journal of Hypertension. 1999. 17: S41-S44.
  4. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. Journal of Hypertension. 2008; 26: 269-275. https://doi.org/10.1097/HJH.0b013e3282f240bf
  5. Czernichow S, Bertrais S, Oppert JM, Galan P, Blacher J, Ducimetiere P, Hercberg S, Zureik M. Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study). International Journal of Obesity. 2005. 29: 826-832. https://doi.org/10.1038/sj.ijo.0802986
  6. Doehner W, Schoene N, Rauchhaus M, Leyva-Leon F, Pavitt DV, Reaveley DA, Schuler G, Coats AJ, Anker SD, Hambrecht R. Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebocontrolled studies. Circulation. 2002. 105: 2619-2624. https://doi.org/10.1161/01.CIR.0000017502.58595.ED
  7. Erdogan D, Gullu H, Caliskan M, Yildirim E, Bilgi M, Ulus T, Sezgin N, Muderrisoglu H. Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults. International Journal of Clinical Practice. 2005. 59: 1276-1282. https://doi.org/10.1111/j.1742-1241.2005.00621.x
  8. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA. 2000. 283: 2404-2410. https://doi.org/10.1001/jama.283.18.2404
  9. Fang JI, Wu JS, Yang YC, Wang RH, Lu FH, Chang CJ. High uric acid level associated with increased arterial stiffness in apparently healthy women. Atherosclerosis. 2014. 236: 389-393. https://doi.org/10.1016/j.atherosclerosis.2014.07.024
  10. Guthikonda S, Sinkey C, Barenz T, Haynes WG. Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers. Circulation. 2003. 107: 416-421. https://doi.org/10.1161/01.CIR.0000046448.26751.58
  11. Haj Mouhamed D, Ezzaher A, Neffati F, Douki W, Gaha L, Najjar MF. Effect of cigarette smoking on plasma uric acid concentrations. Environmental Health and Preventive Medicine. 2011. 16: 307-312. https://doi.org/10.1007/s12199-010-0198-2
  12. Ishizaka N, Ishizaka Y, Toda E, Hashimoto H, Nagai R, Yamakado M. Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals. Atherosclerosis. 2007. 192:131-137. https://doi.org/10.1016/j.atherosclerosis.2006.04.016
  13. Kuo CF, Yu KH, Luo SF, Ko YS, Wen MS, Lin YS, Hung KC, Chen CC, Lin CM, Hwang JS, Tseng WY, Chen HW, Shen YM, See LC. Role of uric acid in the link between arterial stiffness and cardiac hypertrophy: a cross-sectional study. Rheumatology. 2010. 49: 1189-1196. https://doi.org/10.1093/rheumatology/keq095
  14. Lee NB, Park CG. Reproducibility of regional pulse wave velocity in healthy subjects. The Korean Journal of Internal Medicine. 2009. 24: 19-23. https://doi.org/10.3904/kjim.2009.24.1.19
  15. Lim JH, Kim YK, Kim YS, Na SH, Rhee MY, Lee MM. Relationship between serum uric acid levels, metabolic syndrome, and arterial stiffness in Korean. Korean Circulation Journal. 2010. 40: 314-320. https://doi.org/10.4070/kcj.2010.40.7.314
  16. Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG. Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Annals of Internal Medicine. 1980. 93: 817-821. https://doi.org/10.7326/0003-4819-93-6-817
  17. Mule G, Riccobene R, Castiglia A, D'Ignoto F, Ajello E, Geraci G, Guarino L, Nardi E, Vaccaro F, Cerasola G, Cottone S. Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients. Nutrition, Metabolism & Cardiovascular Diseases. 2014. 24: 744-750. https://doi.org/10.1016/j.numecd.2014.01.014
  18. Park JS, Kang S, Ahn CW, Cha BS, Kim KR, Lee HC. Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women. Maturitas. 2012. 73: 344-348. https://doi.org/10.1016/j.maturitas.2012.09.009
  19. Park JS, Nam JS, Cho MH, Yoo JS, Ahn CW, Jee SH, Lee HS, Cha BS, Kim KR, Lee HC. Insulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women. Menopause. 2010. 17: 779-784.
  20. Richette P, Bardin T. Gout. Lancet. 2010. 375: 318-328. https://doi.org/10.1016/S0140-6736(09)60883-7
  21. Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong YY, Kishi R. Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects. Journal of Human Hypertension. 2005. 19: 907-913. https://doi.org/10.1038/sj.jhh.1001913
  22. Saito I, Saruta T, Kondo K, Nakamura R, Oguro T, Yamagami K, Ozawa Y, Kato E. Serum uric acid and the renin-angiotensin system in hypertension. Journal of the American Geriatrics Society. 1978. 26: 241-247. https://doi.org/10.1111/j.1532-5415.1978.tb02396.x
  23. Shin JY, Lee HR, Shim JY. Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men. Vascular Medicine. 2012. 17: 37-43. https://doi.org/10.1177/1358863X11434197
  24. Slater PE, Kaufmann NA, Friedlander Y, Stein Y. Effects of smoking and physical activity on serum uric acid in a Jerusalem population sample. Annals of Human Biology. 1985. 12: 179-184. https://doi.org/10.1080/03014468500007671
  25. Tsioufis C, Kyvelou S, Dimitriadis K, Syrseloudis D, Sideris S, Skiadas I, Katsi V, Stefanadi E, Lalos S, Mihas C, Poulakis M, Stefanadis C. The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. Journal of Human Hypertension. 2011. 25: 554-559. https://doi.org/10.1038/jhh.2010.98
  26. Yiginer O, Ozcelik F, Inanc T, Aparci M, Ozmen N, Cingozbay BY, Kardesoglu E, Suleymanoglu S, Sener G, Cebeci BS. Allopurinol improves endothelial function and reduces oxidantinflammatory enzyme of myeloperoxidase in metabolic syndrome. Clinical Research in Cardiology. 2008. 97: 334-340. https://doi.org/10.1007/s00392-007-0636-3
  27. Yoon SJ, Lee HS, Lee SW, Yun JE, Kim SY, Cho E, Lee SJ, Lee EJ, Lee HY, Park J, Kim HS and Jee SH. The association between adiponectin and diabetes in the Korean population. Metabolism. 2008. 57: 853-857. https://doi.org/10.1016/j.metabol.2008.01.031
  28. Zeng Q, Sun XN, Fan L, Ye P. Correlation of body composition with cardiac function and arterial compliance. Clinical and Experimental Pharmacology and Physiology. 2008. 35: 78-82. https://doi.org/10.1111/j.1440-1681.2007.04749.x