Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Clinical and Genetic Features of Coxiella burnetii in a Patient with an Acute Febrile Illness in Korea

  • Lee, Seung Hun (Division of Zoonoses, Center for Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention) ;
  • Heo, Jung Yeon (Division of Infectious Diseases, Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Lee, Hae Kyung (Division of Zoonoses, Center for Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention) ;
  • Lee, Yeong Seon (Division of Zoonoses, Center for Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention) ;
  • Jeong, Hye Won (Division of Infectious Diseases, Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Hwang, Seon Do (Division of Zoonoses, Center for Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention)
  • Received : 2016.10.31
  • Accepted : 2017.02.25
  • Published : 2017.06.10
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Abstract

Although Q fever is an important zoonotic infection with a worldwide distribution, no human isolates of Coxiella burnetii have been identified in Korea. For the first time, we identified the nucleotide sequence of C. burnetii from a 32-year-old man with an acute febrile illness in Korea. Diagnosis of acute Q fever was confirmed by seroconversion using indirect immunofluorescence antibody assays. Phylogenetic analysis demonstrated high sequence similarity (99.6%-100%) with C. burnetii 16S rRNA sequences identified from the reservoir. These results are the first genetic analysis of C. burnetii in a human case of Q fever in Korea.

Keywords

Acknowledgement

Supported by : Chungbuk National University, Korea National Institute of Health

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