CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
권호 표지
DOI QR코드

DOI QR Code

Association between nutritional status and cognitive functions of the Korean elderly

  • Chung, Hae Kyung (Department of Food and Nutrition, The Research Institute for Eco- Food, Hoseo University) ;
  • Shin, Dayeon (Department of Public Health, Food Studies and Nutrition, Syracuse University) ;
  • Kim, Mi-Hye (Department of Food and Nutrition, Hoseo University)
  • Received : 2017.04.11
  • Accepted : 2017.08.03
  • Published : 2017.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Nutrition is one of the factors influencing cognitive functions. But, the role of nutrition on cognitive functions within the elderly is recognized to a lesser degree. The aim of this academic endeavor was to analyze the affiliation between nutritional status and cognitive functions of the elderly in Korea. 316 subjects, of 114 male and 201 female aged above 65 years, were gathered from university hospital clinics, Elderly Welfare Centers, and Health Welfare Centers located in the district of Seoul, Gyeonggi province, and Incheon in Korea. The cognitive function was tested by the Korean-Mini Mental State Examination (K-MMSE) questionnaire. Nutrition intake was assessed by a 24-hour recall, a food frequency questionnaire (FFQ). Nutrition adequacy and quality were assessed by the Nutrition Screening Initiative (NSI) checklist, the nutritional adequacy ratio (NAR), and the mean adequacy ratio (MAR). The elderly with normal cognitive function status displayed significantly higher levels of calcium, riboflavin, thiamin, folate, vitamin C, vitamin E, vitamin B6, phosphorous, potassium, iron, niacin, zinc, animal fat, animal protein, polyunsaturated fatty acids, total protein, vegetable oil, vegetable protein, fiber than levels of the elderly with moderate cognitive impairment. The K-MMSE score positively correlated with of high consumption of pork, white radish, sea mustard, tomato, tangerine, grape, apple, and ice cream, and K-MMSE was negatively associated with high intake of potato, anchovy, fish cake, and mushroom. The findings suggest that nutritional status is affiliated with cognitive function within the elderly of Korea. The consumption of variety of foods and nutrients ensures adequate cognitive function in the Korean elderly.

Keywords

References

  1. Aisa Y, Miyakawa Y, Nakazato T, Shibata H, Saito K, Ikeda Y, Kizaki M. Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and downregulation of ERK pathways. Am J Hematol. 2005;78:7-14. https://doi.org/10.1002/ajh.20182
  2. Bonaa KH, Bjerve KS, Straume B, Gram IT, Thelle D. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso study. N Engl J Med. 1990;322:795-801. https://doi.org/10.1056/NEJM199003223221202
  3. Bradberry JC, Hilleman DE. Overview of omega-3 Fatty Acid therapies. P T. 2013;38:681-691.
  4. Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, Folstein MF, Tucker KL. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci. 2009;64:888-895.
  5. Calder PC. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015;1851:469-484. https://doi.org/10.1016/j.bbalip.2014.08.010
  6. Carmel R, Green R, Rosenblatt DS, Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program. 2003:62-81.
  7. Deckelbaum RJ, Torrejon C. The omega-3 fatty acid nutritional landscape: health benefits and sources. J Nutr. 2012;142:587s-591s. https://doi.org/10.3945/jn.111.148080
  8. Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet. 2007;369:208-216. https://doi.org/10.1016/S0140-6736(07)60109-3
  9. Fenech M. Folate, DNA damage and the aging brain. Mech Ageing Dev. 2010;131:236-241. https://doi.org/10.1016/j.mad.2010.02.004
  10. Folstein M, Folstein S, McHugh P. Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189-198. https://doi.org/10.1016/0022-3956(75)90026-6
  11. Gao Y, Li C, Yin J, Shen J, Wang H, Wu Y, Jin H. Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Abeta peptide in rats. Environ Toxicol Pharmacol. 2012;33:304-311. https://doi.org/10.1016/j.etap.2011.12.022
  12. Hatloy A, Torheim LE, Oshaug A. Food variety--a good indicator of nutritional adequacy of the diet? A case study from an urban area in Mali, West Africa. Eur J Clin Nutr .1998;52:891-898. https://doi.org/10.1038/sj.ejcn.1600662
  13. Heck A, Fastenrath M, Coynel D, Auschra B, Bickel H, Freytag V, Gschwind L, Hartmann F, Jessen F, Kaduszkiewicz H, Maier W, Milnik A, Pentzek M, Riedel-Heller SG, Spalek K, Vogler C, Wagner M, Weyerer S, Wolfsgruber S, de Quervain DJ, Papassotiropoulos A. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA Psychiatry. 2015;72:1029-1036. https://doi.org/10.1001/jamapsychiatry.2015.1309
  14. Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, Vitamin C, Beta Carotene, and Cognitive Function Among Women With or at Risk of Cardiovascular Disease. Circulation. 2009;119:2772-2780. https://doi.org/10.1161/CIRCULATIONAHA.108.816900
  15. Kang, Yeonwook, Duk L. Na, and Seunghae Hahn. "A validity study on the Korean Mini-Mental State Examination (KMMSE) in dementia patients." Journal of the Korean Neurological Association. 1997;15:300-308.
  16. Kivipelto M, Annerbo S, Hultdin J, Backman L, Viitanen M, Fratiglioni L, Lokk J. Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study. Eur J Neurol. 2009;16:808-813. https://doi.org/10.1111/j.1468-1331.2009.02590.x
  17. Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Nuerobiology of Aging. 2012;33:425.e19-25.e27. https://doi.org/10.1016/j.neurobiolaging.2010.10.006
  18. Kwon YC, Park J-H. Korean version of Mini-Mental State Examination (MMSE-K). Part I: development of the test for the elderly. J Korean Neuropsychiatr Assoc. 1989;28:125-135.
  19. Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. 2000;54:1265-1272. https://doi.org/10.1212/WNL.54.6.1265
  20. Nurk E, Drevon CA, Refsum H, Solvoll K, Vollset SE, Nygard O, Nygaard HA, Engedal K, Tell GS, Smith AD. Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr. 2007;86:1470-1478. https://doi.org/10.1093/ajcn/86.5.1470
  21. Posner BM, Jette AM, Smith KW, Miller DR. Nutrition and health risks in the elderly: the nutrition screening initiative. Am J Public Health. 1993;83:972-978. https://doi.org/10.2105/AJPH.83.7.972
  22. Rural Development Administration. Food composition table for convenient use by general consumers. (Gyeonggi, Korea: Rural Development Administration), 2009.
  23. Saravanan P, Davidson NC, Schmidt EB, Calder PC. Cardiovascular effects of marine omega-3 fatty acids. Lancet. 2010;376:540-550. https://doi.org/10.1016/S0140-6736(10)60445-X
  24. Silvestri L, Camaschella C. A potential pathogenetic role of iron in Alzheimer's disease. Journal of Cellular and Molecular Medicine. 2008;12:1548-1550. https://doi.org/10.1111/j.1582-4934.2008.00356.x
  25. Statistics Korea. Population of Korea 2015. Available at: http://kosis.kr/eng/statisticsList/statisticsList_01List.jsp?vwcd=MT_ETITLE&parentId=A (accessed on 28th August 2017).
  26. Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ, Seshadri S. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012;78:658-664. https://doi.org/10.1212/WNL.0b013e318249f6a9
  27. The Korean Nutrition Society. Dietary reference intakes for Koreans. (Seoul, Korea: The Korean Nutrition Society), pp. 23-28, 2006.
  28. United Nations Department of Economic and Social Affairs (UN DESA). World Population Ageing 2015. Available at: http://www.un.org/en/development/desa/population/publications/pdf/ageing/WPA2015_Report.pdf (accessed on 28th August 2017).
  29. Walker JG, Batterham PJ, Mackinnon AJ, Jorm AF, Hickie I, Fenech M, Kljakovic M, Crisp D, Christensen H. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms--the Beyond Ageing Project: a randomized controlled trial. Am J Clin Nutr. 2012;95:194-203. https://doi.org/10.3945/ajcn.110.007799
  30. Wang J, Zhang Q, Zhang Z, Song H, Li P. Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int J Biol Macromol. 2010;46:6-12. https://doi.org/10.1016/j.ijbiomac.2009.10.015
  31. Wengreen HJ, Munger RG, Corcoran CD, Zandi P, Hayden KM, Fotuhi M, Skoog I, Norton MC, Tschanz J, Breitner JC, Welsh-Bohmer KA. Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. J Nutr Health Aging. 2007;11:230-237.