The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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The Effect of Integrated Medicine for Polycystic Ovary Syndrome Subfertility Patients; A Systematic Review and Meta-Analysis

다낭성 난소 증후군을 이환하는 난임 환자에서 통합 의학 치료의 효과 : 체계적 문헌 고찰 및 메타분석

  • Bae, Ju-Eun (Dept. of Korean OB & GY, School of Korean Medicine, Pusan National University) ;
  • Park, Kyung-Dug (Dept. of Korean OB & GY, School of Korean Medicine, Pusan National University) ;
  • Yoon, Young-Jin (Dept. of Korean OB & GY, School of Korean Medicine, Pusan National University)
  • 배주은 (부산대학교 한방병원 한방부인과) ;
  • 박경덕 (부산대학교 한방병원 한방부인과) ;
  • 윤영진 (부산대학교 한방병원 한방부인과)
  • Received : 2017.10.13
  • Accepted : 2017.11.17
  • Published : 2017.11.24
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Abstract

Objectives: The purpose of this study is to investigate the effect on both herbal medicine periodic therapy and western medicine for polycystic ovary syndrome subfertility. Methods: We searched 8 electronic databases and search keywords were 'PCOS' and 'periodic therapy' or 'cyclic treatment'. We included randomized controlled clinical trials (RCTs) using the periodic therapy combined western medicine for PCOS patients. Results: We selected 8 studies. In studies, there were three studies in which the menstrual cycle was divided into 2 periods, one study divided into 3 periods, and four study divided into 4 periods. The meta-analysis of the 7 trials indicated that pregnancy rates integrated clomiphene and periodic therapy were higher than clomiphene alone. Conclusions: The periodic therapy combined western medicine for PCOS subfertility patients seems to improve pregnancy rates from this research. However, this result should be taken cautiously by unclear risk of bias. It would be necessary to fulfill further clinical study with herbal medicine periodic therapy on PCOS in Korean medicine to establish standard evidence of them.

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References

  1. Kim CH. Recent advences in the management of polycystic ovary syndrome. Obstet & Gynecol Science. 2005;48(8) :1851-69.
  2. The Rotterdam ESHRE/ASRM-sponsored PCOS consesus workshop group. Rivised 2003 consesus workshop on diagnotic criteria and long health risks related to polycystic ovary syndrome. Fertility and sterility. 2004;81(1):19-25. https://doi.org/10.1016/j.fertnstert.2003.10.004
  3. Goo YH, Na YJ. The infertility treatment related with polycystic ovary syndrome. Korean J Obstet Gynecol. 2010;53(10) :869-80. https://doi.org/10.5468/kjog.2010.53.10.869
  4. Kim SH, et al. Recent Acupuncture Therapy for Polycystic Ovary Syndromes : Systematic Review. J Korean Obstet Gynecol. 2014;27(2):71-82. https://doi.org/10.15204/jkobgy.2014.27.2.071
  5. Bae SJ, Kim HJ, Lee DN. Effects of Hyeolbuchukeo-tang on the Estradiol Valerate-induced Polycystic Ovaries and the Conception of Rats. J Korean Obstet Gynecol. 2012;25(2):43-65. https://doi.org/10.15204/JKOBGY.2012.25.2.043
  6. Kim HJ, Kim YS, Lim EM. Effects of Changbuyeukgun-Tang on the Estradiol Valerate-induced Polycystic Ovaries in Rats. J Korean Obstet Gynecol. 2008;21(2):1-16.
  7. Kim JD, et al. Effects of Ojeok-san on the Maturation of Follicles and NGF Expression in Rats with Estradiol Valerate-induced Polycystic Ovaries. J Korean Obstet Gynecol. 2011;24(1) :27-41. https://doi.org/10.15204/JKOBGY.2011.24.1.027
  8. Lee IJ, et al. Effects of Yongdamsagan -tang on the Progression of the Estradiol Valerate-induced Polycystic Ovaries and on the Conception in Rats. J Korean Obstet Gynecol. 2011; 24(3):48-72. https://doi.org/10.15204/JKOBGY.2011.24.3.048
  9. Lee YK, et al. Effects of Gwibi-Tang on the Estradiol Valerate-induced Polycystic Ovaries in Rats. J Korean Obstet Gynecol. 2008;21(3):60-74.
  10. Nam EJ, et al. Effects of Jeongkyeong -Tang on the Estradiol Valerate-induced Polycystic Ovary in Rats. J Korean Obstet Gynecol. 2007;20(1):99-113.
  11. Yang SJ, et al. Effescts of ChangbuDodamTang on the Polycystic Ovaries Induced by Estradiol Valerate in Rats. J Korean Obstet Gynecol. 2002;15(2):1-11.
  12. Yang JM, et al. Effects of Jokyeongjongok -Tang on the Maturation of Follicles and NGF Expression in Rats with Estradiol Valerate-induced Polycystic Ovaries. J Korean Obstet Gynecol. 2011;24(2):52-67. https://doi.org/10.15204/JKOBGY.2011.24.2.052
  13. Yoo YK, et al. Effects of Shingihwanhapchangbudodam-Tang on the Estradiol Valerate-induced Polycystic Ovary in Rats. J Korean Obstet Gynecol. 2007;20(1):84-98.
  14. Yun MH, et al. Effects of Gaeullijin -Tang on the Progression of the Estradiol Valerate-induced Polycystic Ovaries in Rats. J Korean Obstet Gynecol. 2010;23(2):1-19.
  15. Gu HJ, Cho SH. Effects of Gleditsiae Spina(GS) on the Polycystic Ovary Induced by Estradiol Valerate in Rats. J Korean Obstet Gynecol. 2010;23(2) :71-84.
  16. Kim HW, et al. Effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary induced by Estradiol Valerate in rats. J Korean herb Med. 2011; 26(1):81-5.
  17. Park CL, Park KM. Effects of Cyperi Rhizoma on Relevant Conditions of Metabolic Syndrome in Rats with Polycystic Ovary Syndrome. J Korean Obstet Gynecol. 2011;24(4):20-30. https://doi.org/10.15204/JKOBGY.2011.24.4.020
  18. Ryu K, Cho S. Effects of Angelicae Gigantis Radix on Gene Expression of Ovarian Tissue in Polycystic Ovary Syndrome Rats. J Korean Obstet Gynecol. 2011;24(3):28-47. https://doi.org/10.15204/JKOBGY.2011.24.3.028
  19. Shin DS, et al. Effects of Angelicae Gleditsiae Spina on Polycystic Ovary Induced by Estradiol Valerate in Rats. Korean J Oriental Physiology & Pathology. 2011;25(4):658-62.
  20. Yang DS, et al. Effects of Cyperi Rhizoma(CR) on the Polycystic Ovaries Induced by Estradiol Valerate in Rats. J Korean Obstet Gynecol. 2010;23(4) :35-46.
  21. Yeo EJ, et al. Effects of Pinelliae Rhizoma(PR) on Ovarian Tissue in Polycystic Ovary Syndrome(PCOS) Rats. J Korean Obstet Gynecol. 2012; 25(2):66-77. https://doi.org/10.15204/JKOBGY.2012.25.2.066
  22. Kwon SR, et al. Effects of Electro -acupuncture on Sam mgyo(SP-6) .Chagung(CA-111) on Polycystic Ovary in Rats. J Korean Obstet Gynecol. 2003;16(2):76-86.
  23. Cho HS, Lee IS. A Review of Recent Acupuncture Therapy for Polycystic Ovarian Syndrome. J Korean Meridian acupoint. 2011;28(3):165-75.
  24. Won AN, Choi MS, Kim DI. A Review on Clinical Studies of Herbal Treatment for Infertility Caused by Polycystic Ovary Syndrome -Focusing on Chinese Clinical Trials. J Korean Obstet Gynecol. 2014;27(4):43-56. https://doi.org/10.15204/jkobgy.2014.27.4.043
  25. Lee IS. A Review on treatment of female infertility by Periodic Therapy and the method of syndrome differentiation and treatment system. J Korean Obstet Gynecol. 1996;9(1) :127-53.
  26. The Cochrane Collaboration. Cochrane handbook for systematic reviews of interventions.version5.0.2[cited March 13, 2017]. Available from:URL:http: //handbook.cochrane.org/v5.0.2/.
  27. Mao M. Clinical Intervention Effect of Sequential therapy of Nourishing Yin and Tonifying Yang on Polycystic Ovarian Syndrome during Stimulation Cycles. Nansing university of Chinese medicine. 2015.
  28. Su KJ. The Clinical Observation of Effects of Ovulation Induction Cycle of PCOS by Sequential Therapy of Nourishing-Yin and Supplementing-Yang. Nansing university of Chinese medicine. 2013.
  29. Yang S. Follicle Growth Rule and Clinical Research on the Diagnosis and Treatment of the Integrated Chinese and Western Medicine about Polycystic Ovary Syndrome Infertility. Hunan university of Chinese medicine. 2014.
  30. Kuang LJ, He B. Efficacy analysis of treating PCOS by clomiphene plus TCM artificial cycle. Clinical Journal of Chinese Medicine. 2012;20(4):15-6.
  31. Geng HL, Xu lM. Clinical Observation on Treatment of Polycystic Ovarian Syndrome Caused Sterility by Using TCM Periodic Therapy During Ovulation Induction. Chinese Journal of Experimental Traditional Medical Formulae. 2015; 21(10):178-81.
  32. Liang C. Clinical Research of Traditional Chinese Medicine(TCM) Artificial Cycle Combined with Letrozole and Flexor Progesterone Therapy in Western Medicine on Treating PCOS Sterility. Journal of Liaoning University of Traditional Chinese Medicine. 2017; 19(3):206-8.
  33. Liu D, Yan X. Integration of Traditional Chinese and Western Medicine in the Treatment of 30 Cases of Infertility due to Polycystic Ovary Syndrome. Modern Traditional Chinese Medicine. 2011;31(4):14-6.
  34. Yan X, Wang R. Clinical Observation on 30 Cases of Infertility of Polycystic Ovary Syndrome Treated by Combination of Traditional Chinese and Western Medicines. Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2012; 18(5):53-4.
  35. Choi MS, Lee DN, Kim DI. A Survey Study on Use Condition of Korean Medical Institution and Demand of Korean Medical Treatment Project of Infertility in Infertile Couple. J Korean Obstet Gynecol. 2013;26(2): 151-65. https://doi.org/10.15204/jkobgy.2013.26.2.151
  36. Hwang NM, Hwang JH, Kim JE. Evaluation of the National Supporting Program for Infertility Couples and Future Policy Directions in Korea. Seoul:Korea institute for health and social affairs. 2010:62-9, 109-12, 36-50.