Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

A Survey on Ancient Literature Records on Woohwangchungsim-won and its potential clincial application

우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰

  • Oh, Young-Taeck (Korean Medical College of Daejeon University) ;
  • Oh, Hyeon-Muk (Korean Medical College of Daejeon University) ;
  • Kim, Seo-Woo (Korean Medical College of Daejeon University) ;
  • Kim, Won-Yong (Liver and Immunology Research Center, Korean Medical College of Daejeon University) ;
  • Son, Chang-Gue (Liver and Immunology Research Center, Korean Medical College of Daejeon University) ;
  • Cho, Jung-Hyo (Internal Department of Oriental Medicine College, Daejeon University)
  • 오영택 (대전대학교 한의과대학) ;
  • 오현묵 (대전대학교 한의과대학) ;
  • 김서우 (대전대학교 한의과대학) ;
  • 김원용 (대전대학교 한의과대학 간면역센터) ;
  • 손창규 (대전대학교 한의과대학 간면역센터) ;
  • 조정효 (대전대학교 한의과대학 내과학교실)
  • Received : 2017.08.01
  • Accepted : 2017.08.17
  • Published : 2017.09.20
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Abstract

Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

Keywords

References

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