Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

The anti-coagulation effect of natural carbonated hot spring water on DNCB-induced NC/Nga mice.

천연 탄산 온천수의 아토피 유발 쥐 모델에 대한 혈소판 응집 억제 효능 평가

  • Jang, Soonwoo (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon Univ.) ;
  • Park, Junghwan (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon Univ.) ;
  • Kwak, Jinyoung (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon Univ.) ;
  • Go, Youngmi (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon Univ.) ;
  • Ahn, Taekwon (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon Univ.)
  • 장순우 (대전대학교 한의과대학 사상체질의학과) ;
  • 박정환 (대전대학교 한의과대학 사상체질의학과) ;
  • 곽진영 (대전대학교 한의과대학 사상체질의학과) ;
  • 고영미 (대전대학교 한의과대학 사상체질의학과) ;
  • 안택원 (대전대학교 한의과대학 사상체질의학과)
  • Received : 2017.07.25
  • Accepted : 2017.08.10
  • Published : 2017.09.20
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives:Spring water is widely known to relax muscles by promoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assess its influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the mice used in this experiment. NCHW was applied, and the antithrombotic effect was assessed and compared with that of other interventions. The positive control group was treated orally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitory responses to both collagen- and ADP-induced platelet aggregation, whereas the group given aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experiment demonstrated the intrinsic antithrombotic effects of NCHW compared with those of artificially carbonated water, tap water, and aspirin. This result suggests the possibility that NCHW can be used as a supportive and alternative treatment for vascular diseases.

Keywords

References

  1. Korean National Statistical Office, The Leading Causes of Death on 2015 11p available from : URL: http://kostat.go.kr/portal/korea/kor_nw/2/6/2/index.-board?bmode=read&aSeq=356345
  2. Sat Byul Park, The Relation of Cardiovascular Risk Factors to Metabolic Syndrome. J Korean Acad Fam Med. 2005;26:614-620.
  3. Michelson AD. Platelets. 3rd ed.San Diego, Calif:Academic Press. 2002:17
  4. SIM internal medicine, 2nd ed. Seoul:Jeongdam, 2013:213-228.
  5. Ahn Taek Won, The healing Spa 1st ed. Seoul:Zipmoondang, 2016:7-10, 57-65.
  6. Park jong chul, Park ji hwan. The water Thearpy, Seoul: Hyun-moon press, 1995:212-13,222.
  7. Cha YY, Kim DG, Heo SK, Kim EG, Heo YJ, Kong IP et al. A literature review and study on effect of Balneotherapy. The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2007;20(2):132-41.
  8. Lee JW, Go GY, Jung CH, You SJ, Kim YH, Ahn TW. Effect of DOGO phreatic water containing germanium on Atopic Dermatitis in NC/Nga mouse. The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2014;27(4):141-157. https://doi.org/10.6114/jkood.2014.27.4.141
  9. Jang MH, Go GY, Ahn YC, Ahn TW. Effect of DOGO phreatic water containing sulphur on Atopic Dermatitis in NC/Nga Mouse. The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2013;26(3):36-53. https://doi.org/10.6114/jkood.2013.26.3.036
  10. Lee HY. Effects of Antiplatelet Drugs in Cardiovascular Prevention. Korean J Med. 2013;85(1):15-21 https://doi.org/10.3904/kjm.2013.85.1.15
  11. Marcus AJ, Safier LB. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 1993;7(6):516-22. https://doi.org/10.1096/fasebj.7.6.8472890
  12. Packham MA. Role of platelets in thrombosis and hemostasis. Can J Physiol Pharmacol. 1994;72(3):278-84. https://doi.org/10.1139/y94-043
  13. Go GY, Park JH, Jang SW, Kim YH, Park JM, Ahn TW. The anti-atopic effect of natural carbonated hot spring water on DNCB-induced NC/Nga mice under different temperature. The Journal of Daejeon Oriental Medicine Research Institute of Korean Medicine. 2016;25(1):119-132.
  14. Lyu CJ, Introduction to Coagulation System. J Korean Soc Neonatal. 2011;18:1-5. https://doi.org/10.5385/jksn.2011.18.1.1
  15. Kim J, Lee HB, Song HJ, Lee TY, Kim JM. Comparison of Antiplatelet aggregation Effect between the High-Dose and Low-Dose Ticlopidine : A Preliminary Study. J Kor Neurol Ass. 1999;17(3):347-351.
  16. Lim dong-yoon, Lippincott's Illustrated reviews : Pharmacology, 4th ed. Shinilbooks, 2009; 232-233.