Korean Journal of Chemical Engineering

The Korean Institute of Chemical Engineers (한국화학공학회)
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Kinetic and thermodynamic characteristics of crystallization of vancomycin

  • Ha, Geon-Soo (Department of Chemical Engineering, Kongju National University) ;
  • Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
  • Received : 2017.02.15
  • Accepted : 2017.05.24
  • Published : 2017.09.01
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Abstract

We investigated the effect of the major process parameters (crystallization temperature and time) on the efficiency of the vancomycin crystallization process and conducted a kinetic and thermodynamic analysis. The most clear and uniform vancomycin crystals with the highest yield (~98%) were obtained at the optimum crystallization temperature (283 K) and time (1,440 min). The electron microscope, SEM, and XRD analyses showed that intact crystalline vancomycin was obtained when using a crystallization temperature of 283, 288, and 293 K. The kinetic analysis results revealed that the Johnson-Mehl-Avrami-Kolmogorov (JMAK) model was suitable with a high value for $r^2$ (>0.9561) and low value for RMSD (<0.0170). Finally, from the thermodynamic analysis the Gibb's free energy change (${\Delta}G^0$), entropy change (${\Delta}S^0$), and enthalpy change (${\Delta}H^0$) were all negative, indicating that the crystallization process was spontaneous, irreversible, and exothermic.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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