The Journal of the Korean dental association (대한치과의사협회지)

The Korean Dental Association (대한치과의사협회)
권호 표지

Tooth dentin regeneration and its clinical application

치아 상아질의 재생과 그 임상적 활용

  • Bae, Hyun Sook (Department of Dental Hygiene, Namseoul University) ;
  • Park, Joo-Cheol (Department Oral Histology.Developmental Biology, School of Dentistry, Seoul National University)
  • 배현숙 (남서울대학교 치위생학과) ;
  • 박주철 (서울대학교 치의학대학원 구강조직.발생생물학교실)
  • Received : 2017.03.31
  • Accepted : 2017.04.14
  • Published : 2017.05.01
Download PDF
⟨ Previous Next ⟩

Abstract

Teeth are made up of three hard tissues, enamel, dentin, and cementum. The dental pulp is the only non-mineralized connective tooth tissue that is surrounded by dentin. The dentin-pulp complex is able to respond to injury by producing hard tissue deposition. However, dentin is considered one of the most difficult tissues to regenerate because of its unique anatomic and physiologic nature. Recently, advances in understanding the applicability of bio-active dentin regenerating proteins are emerging with the development of biological-based therapies using bio-active materials. Dentin defects were regenerated by the deposition of tubular physiologic dentin after application of the bio-active protein in a beagle dog model. Therefore, the bio-active protein may be able to serve as a novel dentin regenerating material and improve symptoms of dentin hypersensitivity.

Keywords

Acknowledgement

Supported by : 남서울대학교

References

  1. Larmas M. Odontoblast function seen as the response of dentinal tissue to dental caries. Adv Dent Res. 2001;15:68-71. https://doi.org/10.1177/08959374010150011701
  2. Farges JC, Keller JF, Carrouel F, Durand SH, Romeas A, Bleicher F, Lebecque S, Staquet MJ.J Odontoblasts in the dental pulp immune response. Exp Zool B Mol Dev Evol. 2009;312B(5):425-36. https://doi.org/10.1002/jez.b.21259
  3. Pashley DH. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med. 1996;7(2):104-33. https://doi.org/10.1177/10454411960070020101
  4. Tziafas D. The future role of a molecular approach to pulp-dentinal regeneration. Caries Res. 2004;38(3):314-20. https://doi.org/10.1159/000077771
  5. Kawashima N, Okiji T. Odontoblasts: Specialized hard-tissue-forming cells in the dentin-pulp complex. Congenit Anom (Kyoto). 2016;56(4):144-53. https://doi.org/10.1111/cga.12169
  6. Couve E, Osorio R, Schmachtenberg O. The amazing odontoblast: activity, autophagy, and aging. J Dent Res. 2013;92(9):765-72. https://doi.org/10.1177/0022034513495874
  7. Bleicher F, Couble ML, Buchaille R, Farges JC, Magloire H. New genes involved in odontoblast differentiation. Adv Dent Res. 2001;15:30-3. https://doi.org/10.1177/08959374010150010701
  8. Chen Y, Zhang Y, Ramachandran A, George A. DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex. J Dent Res. 2016;95(3):302-10. https://doi.org/10.1177/0022034515610768
  9. Maita E1, Simpson MD, Tao L, Pashley DH. Fluid and protein flux across the pulpodentine complex of the dog in vivo. Arch Oral Biol. 1991;36(2):103-10. https://doi.org/10.1016/0003-9969(91)90072-3
  10. Pashley DH. The influence of dentin permeability and pulpal blood flow on pulpal solute concentrations. J Endod. 1979;5(12):355-61. https://doi.org/10.1016/S0099-2399(79)80060-6
  11. Kim SG. Biological Molecules for the Regeneration of the Pulp-Dentin Complex. Dent Clin North Am. 2017;61(1):127-141. https://doi.org/10.1016/j.cden.2016.08.005
  12. Ricucci D, Loghin S, Lin LM, Spangberg LS, Tay FR. Is hard tissue formation in the dental pulp after the death of the primary odontoblasts a regenerative or a reparative process? J Dent. 2014:42(9):1156-70. https://doi.org/10.1016/j.jdent.2014.06.012
  13. Couve E, Osorio R, Schmachtenberg O. Reactionary Dentinogenesis and Neuroimmune Response in Dental Caries. J Dent Res. 2014;93(8):788-93. https://doi.org/10.1177/0022034514539507
  14. Cao Y, Song M, Kim E, Shon W, Chugal N, Bogen G, Lin L, Kim RH, Park NH, Kang MK. Pulp-dentin Regeneration: Current State and Future Prospects. J Dent Res. 2015;94(11):1544-51. https://doi.org/10.1177/0022034515601658
  15. Lee JH, Lee DS, Choung HW, Shon WJ, Seo BM, Lee EH, Cho JY, Park JC. Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors. Biomaterials 2011;32(36):9696-9706. https://doi.org/10.1016/j.biomaterials.2011.09.007
  16. Oh HJ, Choung HW, Lee HK, Park SJ, Lee JH, Lee DS, Seo BM, ParkJC. CPNE7, a preameloblastderived factor, regulates odontoblastic differentiation of mesenchymal stem cells. Biomaterials 2015;37:208-217. https://doi.org/10.1016/j.biomaterials.2014.10.016
  17. Choung HW, Lee J-H, Shon WJ, Lee JH, Y. Ku, ParkJC. Tertiary dentin formation after indirect pulp capping using protein CPNE7. J Dent Res. 2016;95(8):906-912. https://doi.org/10.1177/0022034516639919