Current Optics and Photonics

Optical Society of Korea (한국광학회)
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Light Scattering Analysis on Coagulation Detection with Magnetic Particles

  • Received : 2018.09.10
  • Accepted : 2018.11.09
  • Published : 2018.12.25
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Abstract

Clotting properties of human blood are important clinical information to monitor for patients with platelet and coagulation disorders. Most devices used to diagnose these disorders utilize blood plasma together with tissue factors and $Ca^{{+}{+}}$ additives. In some instruments, magnetic particles were mixed with blood samples and a rotating magnetic field was applied, resulting in the rotation of magnetic particles, which was probed by impinging light. The working principle seems obvious yet had not been investigated in depth. We modeled the collective behavior of light propagating through magnetic needles, aligned in the direction of the rotating external magnetic field, with scattering light analysis software. Simulation results indicated that the scattering pattern undergoes periodic undulations with respect to the slant angle of the magnetic needles. Also provided is a means of extracting meaningful information from the scattering measurement.

Keywords

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FIG. 1. Magnetic needles made of clustered paramagnetic particles aligned along the local line of applied magnetic field. Paramagnetic particles were ~1 mm long.

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FIG. 2. Light scattering patterns by needles at 60 (top) and 150 degrees (bottom) each with normally incident light.

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FIG. 3. Simulation arrangement. Normal incident light is scattered by magnetic needles. The sensor/receiver collects and counts the photons scattered into that direction.

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FIG. 4. Light scattering by magnetic needles. The pattern repeats itself every 180 degrees.

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FIG. 5. Consideration for the Lambertian nature of the reflection off magnetic needles.

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FIG. 6. Process of photon trapping. (a) Top: Normal incidence (b) Bottom: Oblique incidence.

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FIG. 7. Light scattering by magnetic particles in human blood undergoing coagulation.

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FIG. 8. Modulation values for results in Fig. 7.

References

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