The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Morroniside on anti-inflammation activities in rats following acute myocardial infarction

  • Yu, Bangxing (Department of Experimental Animal Center, XuanWu Hospital of Capital Medical University) ;
  • Zhang, Guoxing (Department of Life Science, Beijing Institute of Technology University) ;
  • An, Yi (Department of Life Science, Beijing Institute of Technology University) ;
  • Wang, Wen (Department of Experimental Animal Center, XuanWu Hospital of Capital Medical University)
  • Received : 2016.11.26
  • Accepted : 2017.03.03
  • Published : 2018.01.01
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Abstract

Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, $IL-1{\beta}$ and $TNF-{\alpha}$ in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, $IL-1{\beta}$ and $TNF-{\alpha}$ in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.

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References

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