Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial

  • Choi, Han Seok (Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital) ;
  • Kim, Sunmi (Research and Development Center, Amorepacific Corporation) ;
  • Kim, Min Jung (Nutrition and Metabolism Research Group, Korea Food Research Institute) ;
  • Kim, Myung-Sunny (Nutrition and Metabolism Research Group, Korea Food Research Institute) ;
  • Kim, Juewon (Research and Development Center, Amorepacific Corporation) ;
  • Park, Chan-Woong (Research and Development Center, Amorepacific Corporation) ;
  • Seo, Daebang (Research and Development Center, Amorepacific Corporation) ;
  • Shin, Song Seok (Research and Development Center, Amorepacific Corporation) ;
  • Oh, Sang Woo (Department of Family Medicine, Dongguk University Ilsan Hospital)
  • Received : 2016.03.23
  • Accepted : 2017.01.04
  • Published : 2018.01.15
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Abstract

Background: Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims of this study were to assess the efficacy and safety of a 12-wk treatment with ginseng berry extract in participants with a fasting glucose level between 100 mg/dL and 140 mg/dL. Methods: This study was a 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total of 72 participants were randomly allocated to two groups of either ginseng berry extract or placebo, and 63 participants completed the study. The parameters related to glucose metabolism were assessed. Results: Although the present study failed to show significant antihyperglycemic effects of ginseng berry extract on the parameters related to blood glucose and lipid metabolism in the total study population, it demonstrated that ginseng berry extract could significantly decrease serum concentration of fasting glucose by 3.7% (p = 0.035), postprandial glucose at 60 min during 75 g oral glucose tolerance test by 10.7% (p = 0.006), and the area under the curve for glucose by 7.7% (p = 0.024) in those with fasting glucose level of 110 mg/dL or higher, while the placebo group did not exhibit a statistically significant decrease. Safety profiles were not different between the two groups. Conclusion: The present study suggests that ginseng berry extract has the potential to improve glucose metabolism in human, especially in those with fasting glucose level of 110 mg/dL or higher. For a more meaningful benefit, further research in people with higher blood glucose levels is required.

Keywords

References

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