Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Combination of Transcranial Electro-Acupuncture and Fermented Scutellaria baicalensis Ameliorates Motor Recovery and Cortical Neural Excitability Following Focal Stroke in Rats

경두개 전침과 발효황금 병행 투여가 흰쥐의 허혈성 뇌세포 손상에 미치는 효과

  • Kim, Min Sun (Department of Physiology, Wonkwang University School of Medicine) ;
  • Koo, Ho (Department of Physiology, Wonkwang University School of Medicine) ;
  • Choi, Myung Ae (Department of Physiology, Wonkwang University School of Medicine) ;
  • Moon, Se Jin (Department of Physiology, Wonkwang University School of Medicine) ;
  • Yang, Seung Bum (Department of Medical Non-commissioned Officer, Wonkwang Health Science University) ;
  • Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University)
  • 김민선 (원광대학교 의과대학 생리학교실) ;
  • 구호 (원광대학교 의과대학 생리학교실) ;
  • 최명애 (원광대학교 의과대학 생리학교실) ;
  • 문세진 (원광대학교 의과대학 생리학교실) ;
  • 양승범 (원광보건대학교 의무부사관과) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실)
  • Received : 2018.11.23
  • Accepted : 2018.12.06
  • Published : 2018.12.27
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Abstract

Objectives : Non-invasive transcranial electrical stimulation is one of therapeutic interventions to change in neural excitability of the cortex. Transcranial electro-acupuncture (TEA) can modulate brain functions through changes in cortical excitability as a model of non-invasive transcranial electrical stimulation. Some composites of fermented Scutellaria baicalenis (FSB) can activate intercellular signaling pathways for activation of brain-derived neurotrophic factor that is critical for formation of neural plasticity in stroke patients. This study was aimed at evaluation of combinatory treatment of TEA and FSB on behavior recovery and cortical neural excitability in rodent focal stroke model. Methods : Focal ischemic stroke was induced by photothrombotic injury to the motor cortex of adult rats. Application of TEA with 20 Hz and $200{\mu}A$ in combination with daily oral treatment of FBS was given to stroke animals for 3 weeks. Motor recovery was evaluated by rotating bean test and ladder working test. Electrical activity of cortical pyramidal neurons of stroke model was evaluated by using multi-channel extracellular recording technique and thallium autometallography. Results : Compared with control stroke group who did not receive any treatment, Combination of TEA and FSB treatment resulted in more rapid recovery of forelimb movement following focal stroke. This combination treatment also elicited increase in spontaneous firing rate of putative pyramidal neurons. Furthermore expression of metabolic marker for neural excitability was upregulated in peri-infract area under thallium autometallography. Conclusions : These results suggest that combination treatment of TEA and FSB can be a possible remedy for motor recovery in focal stroke.

Keywords

References

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