The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Plantaginis asiaticae Folium water extract on body fat loss in high fat-induced obese C57BL/6 mice

차전초 잎의 물 추출물이 고지방식이로 비만 유도된 C57BL/6 생쥐의 체지방 감소에 미치는 영향

  • Kim, So Young (Dept. of Herbal pharmacology, Coll. of Korean Medicine, Daegu Haany Univ.) ;
  • Jeong, Mi Jin (Dept. of Herbal pharmacology, Coll. of Korean Medicine, Daegu Haany Univ.) ;
  • Kim, Yoo Jin (Dept. of Herbal pharmacology, Coll. of Korean Medicine, Daegu Haany Univ.) ;
  • Lee, Un-Tak (Ebiche co., Ltd.) ;
  • Choo, Sung-Tae (Ebiche co., Ltd.) ;
  • Kim, Han-Hyuk (Advanced Medical Fusion Textile Center, Gyeongbuk Technopark Foundation) ;
  • Kim, Mi Ryeo (Dept. of Herbal pharmacology, Coll. of Korean Medicine, Daegu Haany Univ.)
  • 김소영 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 정미진 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김유진 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 이은탁 (농업회사법인 (주)이비채) ;
  • 추성태 (농업회사법인 (주)이비채) ;
  • 김한혁 ((재)경북테크노파크 첨단메디컬융합섬유센터) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실)
  • Received : 2018.02.20
  • Accepted : 2018.03.15
  • Published : 2018.03.30
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Abstract

Objective : Plantago asiatica L. has been used for many years in Korea, China, and Japan for the treatment of many diseases such as anti-inflammatory, anti-asthma and diuretic. But the anti-obesity effect of Plantaginis asiaticae Folium has not been studied yet. Thus, this study aimed to demonstrate the anti-obesity efficacy of Plantaginis asiaticae Folium water extract (PAF) in high fat diet-induced obesity animal model. Method : Male, five-weeks old C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet + Garcinia cambogia 500 mg/kg), PAF 100, 300 (high-fat diet + PAF 100, 300 mg/kg. Treatments were performed daily for 6 weeks per os. We evaluated the changes of body weight, white adipose tissues weight, hepatic and fecal lipids level, pancreatic lipase activity and lipid profiles in plasma. Result : Body weights, adipose tissue weights and FER were significantly lower in mice fed the high-fat diet with PAF treatment than in mice fed the high-fat diet alone. In plasma, TG, TC, LDL-C, ATS and ALT levels significantly decreased in PAF groups compared with HFD group. Also, hepatic triglyceride (TG) levels decreased and fecal TG increased in PAF groups compared to HFD group. In addition, the activity of pancreatic lipase was decreased in the PAF groups compared to that of HFD group. Conclusion: These results suggest PAF extract is effective in preventing and improvement obesity, so it might be a potential and safe material for anti-obesity agent of weight control or functional supplements.

Keywords

References

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