Pediatric Infection and Vaccine

  • 제25권1호
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  • Pages.8-16
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  • 2018
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  • 2384-1079(pISSN)
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  • 2384-1087(eISSN)
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)
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바이러스성 크루프로 입원하는 소아 환자의 역학적 특성과 임상적 중증도 평가

Epidemiology and Clinical Severity of the Hospitalized Children with Viral Croup

  • 전인수 (연세대학교 원주의과대학 소아청소년과학교실) ;
  • 조원제 (연세대학교 원주의과대학 소아청소년과학교실) ;
  • 이정민 (연세대학교 원주의과대학 소아청소년과학교실) ;
  • 김황민 (연세대학교 원주의과대학 소아청소년과학교실)
  • Jeon, In Soo (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Cho, Won Je (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Lee, Jeongmin (Department of Pediatrics, Yonsei University Wonju College of Medicine) ;
  • Kim, Hwang Min (Department of Pediatrics, Yonsei University Wonju College of Medicine)
  • 투고 : 2017.08.23
  • 심사 : 2017.10.19
  • 발행 : 2018.04.25
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초록

목적: 본 연구는 바이러스성 크루프로 입원하는 환아의 임상적 및 역학적 특성을 분석하여 원인 바이러스 감염에 따른 중증도를 평가하고자 하였다. 방법: 2013년 5월부터 2016년 12월까지 원주세브란스기독병원 소아청소년과에 바이러스성 크루프로 입원한 10세 이하 환아 중 비강인두도말 검체 채취 및 다중 역전사중합효소연쇄반응 검사를 하여 호흡기 바이러스가 검출된 302명을 대상으로 의무기록을 후향적으로 검토하였다. 바이러스성 크루프의 중 증도를 평가하기 위하여 Westley의 점수제를 사용하였다. 결과: 전체 302명 중 중증 바이러스성 크루프로 입원한 환아는 149명(49.3%)이었으며, 이 중 남아가 88명, 여아가 61명으로 남녀 비는 1.44:1이었다. Parainfluenza virus가 110예(48.7%)로 거의 절반에 가까운 빈도를 보였으며, 이후로 influenza virus (15.5%), human rhinovirus (11.9%), respiratory syncytial virus (10.2%) 순이었다. 중증 바이러스성 크루프와 원인 바이러스와의 연관성에 대한 분석에서는 parainfluenza virus 2형에서만 위험도가 의미 있게 높은 것으로 나타났다. Parainfluenza virus 2형은 연령에 따라서는 발병 빈도에 차이가 없었으나 여름, 가을에 상대적으로 더 높은 감염 빈도를 보였다. 결론: 본 연구에서 중증 바이러스성 크루프와 연관이 있었던 바이러스는 parainfluenza virus 2형이 유일하였다. 추후 전향적, 다기관 연구 및 추가적인 변수들을 복합적으로 고려하여 원인 바이러스 감염에 따른 중증도를 재확인하고, 원인 바이러스에 대한 지역별, 시기별, 연령별 분석이 필요하다.

Purpose: In this study, the clinical and epidemiological characteristics of patients admitted for viral croup were analyzed to evaluate disease severity based on the organism that caused the infection. Methods: We retrospectively reviewed the medical records of 302 patients who were admitted to the Department of Pediatrics at the Wonju Severance Hospital between May 2013 and December 2016 for viral croup. Patients who showed positive results on multiplex polymerase chain reaction were subsequently diagnosed with respiratory virus infection. The Westley scoring system was used to evaluate the severity of viral croup. Results: Of the 302 patients, 149 were admitted due to severe viral croup, including 88 boys and 61 girls, with a boy-to-girl ratio of 1.44:1. About 110 cases of parainfluenza virus infection have been reported, which accounted for almost half of the total cases. The other identified viruses included influenza virus, human rhinovirus, and respiratory syncytial virus. Analysis of the association between severe viral croup and causative pathogen revealed that only parainfluenza type 2 virus showed a significantly high risk. Parainfluenza type 2 virus did not show an age-based difference in frequency but showed relatively a higher frequency of infections during the summer and fall. Conclusions: In this study, parainfluenza virus type 2 was the only virus associated with severe viral croup. To facilitate proper preventive management, treatment, and prognosis evaluation of viral croup, prospective and multicenter studies should assess the additional variables and the severity of the virus. Additionally, further studies should be conducted to assess age-dependent influences, as well as the regional and seasonal incidence of viral infection.

키워드

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피인용 문헌

  1. Clinical presentation of croup in children according to causative viruses vol.6, pp.6, 2018, https://doi.org/10.4168/aard.2018.6.6.290
  2. Seasonality and etiology of croup in pediatric patients hospitalized with lower respiratory tract infections: A long-term study between 2009 and 2017 vol.7, pp.1, 2019, https://doi.org/10.4168/aard.2019.7.1.28
  3. Etiology of respiratory virus in croup with children in Korea vol.7, pp.2, 2018, https://doi.org/10.4168/aard.2019.7.2.65
  4. Seasonal patterns and etiologies of croup in children during the period 2010-2015: A multicenter retrospective study vol.7, pp.2, 2018, https://doi.org/10.4168/aard.2019.7.2.78
  5. Effects of climatic factors on human parainfluenza 1, 2, and 3 infections in Cheonan, Republic of Korea vol.28, pp.8, 2018, https://doi.org/10.1007/s11356-020-11515-3