DOI QR코드

DOI QR Code

Characterization of Bioactive Compounds of Domestic Tomato Varieties

국내산 토마토 품종의 생리활성 물질의 특성

  • Ahn, Jun-Bae (Dept. of Food Service & Culinary Arts, Seowon University)
  • 안준배 (서원대학교 호텔외식조리학과)
  • Received : 2017.11.20
  • Accepted : 2018.01.10
  • Published : 2018.01.31

Abstract

The aim of this study was to investigate bioactive compounds from three domestic tomato varieties (Rafito, Momotaro TY Winner, and Medison). Lycopene, ${\beta}-carotene$ and polyphenols were quantified and identified using HPLC and LC-MS/MS. The levels of lycopene ranged from 28.36 mg/100 g to 60.18 mg/100 g. The content of ${\beta}-Carotene$ ranged from 2.00 mg/100 g to 2.92 mg/100 g. Ten kinds of polyphenol compounds were identified: caffeic acid-hexose isomer (I), caffeic acid-hexose isomer (II), 3-caffeoylquinic acid, 5-caffeoylquinic acid, caffeoylquinic acid isomer, quercetin-3-apiosylrutinoside, quercetin-3-rutinoside, di-caffeoylquinic acid, tri-caffeoylquinic acid, and naringenin chalcone. The level of 5-caffeoylquinic acid was the highest in domestic tomato varieties, ranging from 12.71 mg/100 g to 28.40 mg/100 g. The content of quercetin-3-rutinoside ranged from 3.74 mg/100 g to 17.64 mg/100 g. The contents of 3-caffeoylquinic acid and quercetin-3-apiosylrutinoside were 1.01~2.31 mg/100 g and 5.84~6.83 mg/100 g, respectively. Arrestingly naringenin chalcone was found only in Medison variety (36.82 mg/100 g). These results revealed that domestic tomato can be a good source of bioactive compounds for human health.

Keywords

References

  1. Ahn, J. B. (2016). Amino acid, amino acid metabolite, and GABA content of three domestic tomato varieties. Culinary Science & Hospitality Research, 22(6), 71-77. https://doi.org/10.20878/cshr.2016.22.6.007007007
  2. Ana, P., Franz, B., ZZeljan, M., Ana, M., Biljana, N., & Nikola, K. (2009). Identification and quantification of flavonoids and phenolic acids in burr parsley (Caucalis platycarpos L.), using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. Molecules, 14(7), 2466-2490. https://doi.org/10.3390/molecules14072466
  3. Boudjelal, A., Henchiri, C., Siracusa, L., Sari, M., & Ruberto, G. (2012). Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion. Fitoterapia, 83(2), 286-292. https://doi.org/10.1016/j.fitote.2011.11.005
  4. Choi, S. H., Kim, D. H., & Kim, D. S. (2011) Comparison of ascorbic acid, lycopene, ${\beta}$-carotene and ${\alpha}$-carotene contents in processed tomato products, tomato cultivar and part. Culinary Science & Hospitality Research, 17(4), 263-272. https://doi.org/10.20878/cshr.2011.17.4.018
  5. Choi, S. H., Lee, S. H., Kim, H. J., Lee, I. S., Nobuyuki, K., Levin, C. E., & Friedman, M. (2010). Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts. Journal of Agricultural & Food Chemistry, 58(13), 7547-7556. https://doi.org/10.1021/jf100162j
  6. Davies, J. N., & Hobson, G. E. (1981). Constituents of tomato fruit - the influence of environment, nutrition, and genotype. Critical Reviews in Food Science & Nutrition, 15(3), 205-280. https://doi.org/10.1080/10408398109527317
  7. Edward, G. (1999). Tomatoes, tomato-based products, lycopene and cancer. Journal of the National Cancer Institute, 91(4), 317-331. https://doi.org/10.1093/jnci/91.4.317
  8. Edward, G., Eric, B. R., Yan, L., Meir, J. S., & Walter, C. W. (2002). A prospective study of tomato products, lycopene and prostate cancer risk. Journal of the National Cancer Institute, 94(5), 391-398. https://doi.org/10.1093/jnci/94.5.391
  9. Erge, H. S., & Karadeniz, F. (2011). Bioactive compounds and antioxidant activity of tomato cultivars. International Journal of Food Properties, 14(5), 968-977. https://doi.org/10.1080/10942910903506210
  10. Giovannucci, E. (2005). Tomato products, lycopene, and prostate cancer: A review of the epidemiological literature. The Journal of Nutrition, 135(8), 2030S-2031S. https://doi.org/10.1093/jn/135.8.2030S
  11. Gougoulias, N., Papachatzis, A., Kalorizou, H., Vagelas, I., Giurgiulescu, L., & Chouliaras, N. (2012). Total phenolic, lycopene and antioxidant activity of hydroponically cultured tomato sandin F1. Carpathian Journal of Food Science & Technology, 4(2), 46-51.
  12. Graeme, E. H., Peter, A., & Timothy, J. D. (1983). Assessing the coulor of tomato fruit during repening. Journal of the Science of Food & Agriculture, 34(3), 286-292. https://doi.org/10.1002/jsfa.2740340312
  13. Guil-Guerrero, J. L., & Rebolloso-Fuentes, M. M. (2009). Nutrient composition and antioxidant activity of eight tomato (Lycopersicon esculentum) varieties. Journal of Food Composition & Analysis, 22(2), 123-129. https://doi.org/10.1016/j.jfca.2008.10.012
  14. Hirai, S., Kim, Y. I., Goto, T., Kang, M. S., Yoshimura, M., Obata, A., … , Kawada, T. (2007). Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Science, 81(16), 1272-1279. https://doi.org/10.1016/j.lfs.2007.09.001
  15. Ilahy, R., Hdider, C., Lenucci, M. S., Tlili, I., & Dalessandro, G. (2011). Antioxidant activity and bioactive compound changes during fruit ripening of high-lycopene tomato cultivars. Journal of Food Composition and Analysis, 24(4), 588-595. https://doi.org/10.1016/j.jfca.2010.11.003
  16. Iwamura, C., Shindoda, K., Yoshimura, M., Watanabe, Y., Obata, A., & Nakayama, T. (2010). Naringenin chalcone suppresses allergic asthma by inhibiting the Type-2 function of CD4 T cells. Allergology International, 59(1), 67-73. https://doi.org/10.2332/allergolint.09-OA-0118
  17. Jung, C. H., Cho, C. H., & Kim, C. J. (2007). Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin. Archives of Pharmical Research, 30(12), 1599–1607. https://doi.org/10.1007/BF02977330
  18. Jung, J. K., Lee, S. U., Kozukue, N., Levin, C. E., & Friedman, M. (2011). Distribution of phenolic compounds and antioxidative activities in parts of sweet potato (Ipomoea batata L.) plants and in home processed roots. Journal of Food Composition & Analysis, 24(1), 29-37. https://doi.org/10.1016/j.jfca.2010.03.025
  19. Kim, H. Y., & Ahn, J. B. (2014). Physicochemical properties of a Betatini variety of Lycopersicon esculentum var. cerasiforme (cherry tomato). Food Engineering Progress, 18(3), 222-228. https://doi.org/10.13050/foodengprog.2014.18.3.222
  20. Kim, H. K., Chun, J. H., & Kim, S. J. (2015). Method development and analysis of carotenoid compositions in various tomatoes. Korean Journal of Environmental Agriculture, 34(3), 196-203. http://dx.doi.org/10.5338/KJEA.2015.34.3.23
  21. Lee, H. N., Joo, J. H., Oh, J. S., Choi, S. W., & Seo, D. W. (2014). Regulatory effects of Siegesbeckia glabrescens on non-small cell lung cancer cell proliferation and invasion. The American Journal of Chinese Medicine, 42(2), 453-463. https://doi.org/10.1142/S0192415X1450030X
  22. Lee, M. S., & Kim, G. H. (1986). Quality evaluation of raw tomato fruits. Journal of Food Science, 18(5), 335-338.
  23. Lenucci, M. S., Cadinu, D., Taurino, M., Piro, G., & Dalessandro, G. (2006). Antioxidant composition in cherry and highpigment tomato cultivars. Journal of Agricultural & Food Chemistry, 54(7), 2606-2613. https://doi.org/10.1021/jf052920c
  24. Liu, S. L., Peng, B. J., Zhong, Y. L., Liu, Y. L., Song, Z., & Wang, Z. (2015). Effect of 5-caffeoylquinic acid on the NF-${\kappa}B$ signaling pathway, peroxisome proliferator-activated receptor gamma 2, and macrophage infiltration in high-fat diet-fed Sprague-Dawley rat adipose tissue. Food & Function, 6(8), 2779-2786. https://doi.org/10.1039/C5FO00626K
  25. Maietta, M., Colombo, R., Lavecchia, R., Sorrenti, M., Zuorro, A., & Papetti, A. (2017). Artichoke (Cynara cardunculus L. var. scolymus) waste as a natural source of carbonyl trapping and antiglycative agents. Food Research International, 100 (1), 780-790. https://doi.org/10.1016/j.foodres.2017.08.007
  26. Mares-Perlman, J. A., Fisher, A. I., Klein, R., Patla, M., Block, G., Millen, A. E., & Wright, J. D. (2001). Lutein and zeaxanthin in the diet and serum and their relation to agerelated maculopathy in the third national health and nutrition examination survey. American Journal of Epidemiology, 153(5), 424-432. https://doi.org/10.1093/aje/153.5.424
  27. Metodiewa, D., Kochman, A., & Karolczak, S. (1997). Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylaminoethyl ethers of flavaone oximes: A comparison with natural polyphenolic flavonoid rutin action. Biochemistry & Molecular Biology International, 41(5), 1067-1075.
  28. Moco, S., Bino, R. J., Vorst, O., Verhoeven, H. A., Groot, J., van Beek, T. A., … , Ric de Vos, C. H. (2006). A liquid chromatography-mass spectrometry-based metabolome database for tomato. Plant Physiology, 141(4), 1205-1218. https://doi.org/10.1104/pp.106.078428
  29. Mullen, W., Marks, S. C., & Crozier, A. (2007). Evaluation of phenolic compounds in commercial fruit juices and fruit drinks. Journal of Agricultural & Food Chemistry, 55(8), 3148-3157. https://doi.org/10.1021/jf062970x
  30. Murad, L. D., Soares, N. C., Brand, C., Monteiro, M. C., & Teodoro, A. J. (2015). Effects of caffeic and 5-caffeoylquinic acids on cell viability and cellular uptake in human colon adenocarcinoma cells. Nutrition & Cancer, 67(3), 532-542. https://doi.org/10.1080/01635581.2015.1004736
  31. Na, H. S., Kim, J. Y., Yun, S. H., Park, H. J., Choi, G. C., Yang, S. I., … , Cho, J. Y. (2013). Phytochemical contents of agricultural products cultivated by region. Korean Journal of Food Preservation, 20(4), 451-458. https://doi.org/10.11002/kjfp.2013.20.4.451
  32. Navarro-Nunez, L., Lozano, M. L., Palomo, M., Martínez, C., Vicente, V., Castillo, J., … , Rivera, J. (2008). Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. Journal of Agricultural & Food Chemistry, 56(9), 2970–2976. https://doi.org/10.1021/jf0723209
  33. Oshima, S., Ojima, F., Sakamoto, H., Ishiguro, Y., & Terao, J. (1998). Supplementation with carotenoids inhibits singlet oxigen-mediated oxidation of human plasma low-density lipoprotein. Journal of Agricultural & Food Chemistry, 44 (8), 2306-2309. https://doi.org/10.1021/jf950350i
  34. Stahl, W., Heinrich, U., Wiseman, S., Eichler, O., Sies, H., & Tronnier, H. (2001). Dietary tomato paste protects against ultraviolet light-induced erythema in human. Journal of Nutrition, 131(5), 1449-1451. https://doi.org/10.1093/jn/131.5.1449
  35. Talalay, P. (2000). Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors, 2(1), 5-11.
  36. Toma, R. B., Frank, G. C., Nakayama, K., & Fawfik, E. (2008). Lycopene content in raw tomato varieties and tomato products. Journal of Food Service, 19(2), 127-132.
  37. Yamamoto, T., Yoshimura, M., Yamaguchi, F., Kouchi, T., Tsuji, R., Saito, M., … , Kikuchi, M. (2004). Anti-allergic activity of naringenin chalcone from a tomato skin extract. Bioscience, Biotechnololgy, & Biochemistry, 68(8), 1706-1711. https://doi.org/10.1271/bbb.68.1706