DOI QR코드

DOI QR Code

Association between Egg Consumption and Metabolic Disease

  • Park, Seon-Joo (Department of Food and Nutrition, College of BioNano Technology, Gachon University) ;
  • Jung, Ji-hye (Institute for Clinical Nutrition, Inje University) ;
  • Choi, Sang-Woon (Chaum Life Center, CHA University School of Medicine) ;
  • Lee, Hae-Jeung (Department of Food and Nutrition, College of BioNano Technology, Gachon University)
  • Received : 2018.02.08
  • Accepted : 2018.02.28
  • Published : 2018.04.30

Abstract

The effect of high egg intake on metabolic syndrome (MetS), a major risk factor for cardiovascular disease (CVD), has not been clearly elucidated. This study was conducted to review the literature related to egg consumption and the risk of metabolic disease as well as to examine the association between high egg intake and MetS in Korean adults. A literature review was conducted using published papers in PubMed and EMBASE through December 2017. We have reviewed 26 articles, which were associated with egg consumption and metabolic diseases, and found that the results were controversial. Therefore, we analyzed data from 23,993 Korean adults aged 19 yrs and older. MetS was defined based on criteria from the Adult Treatment Panel III. Egg consumption of 4-6 times/wk and 1 time/day were significantly associated with reduced prevalence of MetS (Odds ratio (OR)=0.82; 95% Confidence interval (CI)=0.71-0.95 for 4-6 times/wk, OR=0.83; 95% CI=0.69-0.99 for 1 time/day) compared to those who consumed eggs less than once monthly. However, consuming two or more eggs per day was not associated with MetS. As for the components of MetS, an egg intake of once daily decreased the prevalence of abdominal obesity and an intake of 2-7 eggs weekly was shown to prevent a reduction in the high-density lipoprotein cholesterol levels. This study suggests that while consuming eggs 4-7 times weekly is associated with a lower prevalence of MetS, consuming two or more eggs daily is not associated with a reduced risk for MetS.

Keywords

References

  1. Andersen CJ. 2015. Bioactive egg components and inflammation. Nutrients 7:7889-7913. https://doi.org/10.3390/nu7095372
  2. Appleby PN, Thorogood M, Mann JI, Key TJ. 1999. The Oxford Vegetarian Study: An overview. Am J Clin Nutr 70:525s-531s. https://doi.org/10.1093/ajcn/70.4.525
  3. Austin MA. 1994. Genetic and environmental influences on LDL subclass phenotypes. Clin Genet 46:64-70.
  4. Ballesteros MN, Valenzuela F, Robles AE, Artalejo E, Aguilar D, Andersen CJ, Valdez H, Fernandez ML. 2015. One egg per day improves inflammation when compared to an oatmeal-based breakfast without increasing other cardiometabolic risk factors in diabetic patients. Nutrients 7:3449-3463. https://doi.org/10.3390/nu7053449
  5. Bansilal S, Castellano JM, Fuster V. 2015. Global burden of CVD: Focus on secondary prevention of cardiovascular disease. Int J Cardiol 201:S1-S7. https://doi.org/10.1016/S0167-5273(15)31026-3
  6. Blesso CN, Andersen CJ, Barona J, Volek JS, Fernandez ML. 2013a. Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome. Metabolism 62:400-410. https://doi.org/10.1016/j.metabol.2012.08.014
  7. Blesso CN, Andersen CJ, Barona J, Volk B, Volek JS, Fernandez ML. 2013b. Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome. J Clin Lipidol 7:463-471. https://doi.org/10.1016/j.jacl.2013.03.008
  8. Blesso CN, Andersen CJ, Bolling BW, Fernandez ML. 2013c. Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome. Food Funct 4:213-221. https://doi.org/10.1039/C2FO30154G
  9. Blesso CN. 2015. Egg phospholipids and cardiovascular health. Nutrients 7:2731-2747. https://doi.org/10.3390/nu7042731
  10. Diez-Espino J, Basterra-Gortari FJ, Salas-Salvado J, Buil-Cosiales P, Corella D, Schroder H, Estruch R, Ros E, Gomez-Gracia E, Aros F, Fiol M, Lapetra J, Serra-Majem L, Pinto X, Babio N, Quiles L, Fito M, Marti A, Toledo E, Predimed Investigators. 2017. Egg consumption and cardiovascular disease according to diabetic status: The Predimed study. Clin Nutr 36:1015-1021. https://doi.org/10.1016/j.clnu.2016.06.009
  11. DiMarco DM, Missimer A, Murillo AG, Lemos BS, Malysheva OV, Caudill MA, Blesso CN, Fernandez ML. 2017. Intake of up to 3 eggs/day increases HDL cholesterol and plasma choline while plasma trimethylamine-N-oxide is unchanged in a healthy population. Lipids 52:255-263. https://doi.org/10.1007/s11745-017-4230-9
  12. Djousse L, Gaziano JM, Buring JE, Lee IM. 2009. Egg consumption and risk of type 2 diabetes in men and women. Diabetes Care 32:295-300. https://doi.org/10.2337/dc08-1271
  13. Djousse L, Gaziano JM. 2008a. Egg consumption and risk of heart failure in the physicians' health study. Circulation 117:512-516. https://doi.org/10.1161/CIRCULATIONAHA.107.734210
  14. Djousse L, Gaziano JM. 2008b. Egg consumption in relation to cardiovascular disease and mortality: The Physicians' Health Study. Am J Clin Nutr 87:964-969. https://doi.org/10.1093/ajcn/87.4.964
  15. Djousse L, Kamineni A, Nelson TL, Carnethon M, Mozaffarian D, Siscovick D, Mukamal KJ. 2010. Egg consumption and risk of type 2 diabetes in older adults. Am J Clin Nutr 92:422-427. https://doi.org/10.3945/ajcn.2010.29406
  16. Djousse L, Petrone AB, Hickson DA, Talegawkar SA, Dubbert PM, Taylor H, Tucker KL. 2016. Egg consumption and risk of type 2 diabetes among African Americans: The Jackson Heart Study. Clin Nutr 35:679-684. https://doi.org/10.1016/j.clnu.2015.04.016
  17. European Food Safety Authority Panel on Dietetic Products, Nutrition, and Allergies. 2010. Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA Journal 8:1461.
  18. Fuller NR, Caterson ID, Sainsbury A, Denyer G, Fong M, Gerofi J, Baqleh K, Williams KH, Lau NS, Markovic TP. 2015a. The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: The Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial. Am J Clin Nutr 101:705-713. https://doi.org/10.3945/ajcn.114.096925
  19. Fuller NR, Sainsbury A, Caterson ID, Markovic TP. 2015b. Egg consumption and human cardio-metabolic health in people with and without diabetes. Nutrients 7:7399-7420. https://doi.org/10.3390/nu7095344
  20. Galassi A, Reynolds K, He J. 2006. Metabolic syndrome and risk of cardiovascular disease: A meta-analysis. Am J Med 119:812-819. https://doi.org/10.1016/j.amjmed.2006.02.031
  21. Goldberg S, Gardener H, Tiozzo E, Kuen CY, Elkind MS, Sacco RL, Rundek T. 2014. Egg consumption and carotid atherosclerosis in the Northern Manhattan study. Atherosclerosis 235:273-280. https://doi.org/10.1016/j.atherosclerosis.2014.04.019
  22. Grundy SM, Brewer HB, Jr. Cleeman JI, Smith SC, Jr. Lenfant C, National Heart Lung, Blood Institute, American Heart Association. 2004. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 24: e13-18. https://doi.org/10.1161/01.ATV.0000111245.75752.C6
  23. Guo J, Hobbs DA, Cockcroft JR, Elwood PC, Pickering JE, Lovegrove JA, Givens DI. 2017. Association between egg consumption and cardiovascular disease events, diabetes and all-cause mortality. Eur J Nutr doi: 10.1007/s00394-017-1566-0.
  24. Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC. 1999. A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 281:1387-1394. https://doi.org/10.1001/jama.281.15.1387
  25. Kurotani K, Nanri A, Goto A, Mizoue T, Noda M, Oba S, Sawada N, Tsugane S, Japan Public Health Center-based Prospective Study Group. 2014. Cholesterol and egg intakes and the risk of type 2 diabetes: The Japan public health center-based prospective study. Br J Nutr 112:1636-1643. https://doi.org/10.1017/S000711451400258X
  26. Kweon S, Kim Y, Jang MJ, Kim Y, Kim K, Choi S, Chun C, Khang YH, Oh K. 2014. Data resource profile: The Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol 43:69-77. https://doi.org/10.1093/ije/dyt228
  27. Lajous M, Bijon A, Fagherazzi G, Balkau B, Boutron-Ruault MC, Clavel-Chapelon F. 2015. Egg and cholesterol intake and incident type 2 diabetes among French women. Br J Nutr 114:1667-1673. https://doi.org/10.1017/S0007114515003190
  28. Larsson SC, Akesson A, Wolk A. 2015. Egg consumption and risk of heart failure, myocardial infarction, and stroke: Results from 2 prospective cohorts. Am J Clin Nutr 102:1007-1013. https://doi.org/10.3945/ajcn.115.119263
  29. Li Y, Zhou C, Zhou X, Li L. 2013. Egg consumption and risk of cardiovascular diseases and diabetes: A meta-analysis. Atherosclerosis 229:524-530. https://doi.org/10.1016/j.atherosclerosis.2013.04.003
  30. Ministry of Health and Welfare. The Korea National Health and Nutrition Examination Survey. 2011. Republic of Korea.
  31. Nakamura Y, Iso H, Kita Y, Ueshima H, Okada K, Konishi M, Inoue M, Tsugane S. 2006. Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study. Br J Nutr 96:921-928.
  32. Pyorala K. 1987. Dietary cholesterol in relation to plasma cholesterol and coronary heart disease. Am J Clin Nutr 45:1176-1184. https://doi.org/10.1093/ajcn/45.5.1176
  33. Qureshi AI, Suri FK, Ahmed S, Nasar A, Divani AA, Kirmani JF. 2007. Regular egg consumption does not increase the risk of stroke and cardiovascular diseases. Med Sci Monit 13, CR1-8.
  34. Ratliff JC, Mutungi G, Puglisi MJ, Volek JS, Fernandez ML. 2008. Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutr Metab(Lond) 5:6.
  35. Shi Z, Yuan B, Zhang C, Zhou M, Holmboe-Ottesen G. 2011. Egg consumption and the risk of diabetes in adults, Jiangsu, China. Nutrition 27:194-198. https://doi.org/10.1016/j.nut.2010.01.012
  36. Shin JY, Xun P, Nakamura Y, He K. 2013. Egg consumption in relation to risk of cardiovascular disease and diabetes: A systematic review and meta-analysis. Am J Clin Nutr 98:146-159. https://doi.org/10.3945/ajcn.112.051318
  37. Shin S, Lee HW, Kim CE, Lim J, Lee JK, Lee SA, Kang D. 2017. Egg consumption and risk of metabolic syndrome in Korean adults: Results from the health examinees study. Nutrients 9:687. https://doi.org/10.3390/nu9070687
  38. Sook M. 2003. Food consumption trends and nutrition transition in Korea. Malays J Nutr 9:7-17.
  39. Spence JD, Jenkins DJ, Davignon J. 2012. Egg yolk consumption and carotid plaque. Atherosclerosis 224:469-473. https://doi.org/10.1016/j.atherosclerosis.2012.07.032
  40. Tanasescu M, Cho E, Manson JE, Hu FB. 2004. Dietary fat and cholesterol and the risk of cardiovascular disease among women with type 2 diabetes. Am J Clin Nutr 79:999-1005. https://doi.org/10.1093/ajcn/79.6.999
  41. Virtanen JK, Mursu J, Tuomainen TP, Virtanen HE, Voutilainen S. 2015. Egg consumption and risk of incident type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 101:1088-1096. https://doi.org/10.3945/ajcn.114.104109
  42. Wallin A, Forouhi NG, Wolk A, Larsson SC. 2016. Egg consumption and risk of type 2 diabetes: A prospective study and dose-response meta-analysis. Diabetologia 59:1204-1213. https://doi.org/10.1007/s00125-016-3923-6
  43. Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. 2005. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 112:3066-3072. https://doi.org/10.1161/CIRCULATIONAHA.105.539528
  44. Woo HW, Choi BY, Kim MK. 2016. Cross-sectional and longitudinal associations between egg consumption and metabolic syndrome in adults ${\geq}$ 40 years old: The Yangpyeong cohort of the Korean Genome and Epidemiology Study (KoGES_Yangpyeong). PLoS One 11:e0147729. https://doi.org/10.1371/journal.pone.0147729
  45. World Health Organization. 2002. Diet, nutrition and the prevention of chronic diseases: Report of a Joint WHO/FAO expert consultation. Geneva, Switzerland.
  46. World Health Organization. Regional Office for the Western Pacific. 2000. The Asia-Pacific perspective: Redefining obesity and its treatment. Health Communications Australia, Sydney, Australia.
  47. Zazpe I, Beunza JJ, Bes-Rastrollo M, Warnberg J, de la Fuente-Arrillaga C, Benito S, Vazquez Z, Martinez-Gonzalez MA, SUN Project Investigators. 2011. Egg consumption and risk of cardiovascular disease in the SUN Project. Eur J Clin Nutr 65:676-682. https://doi.org/10.1038/ejcn.2011.30

Cited by

  1. Dietary Cholesterol and the Lack of Evidence in Cardiovascular Disease vol.10, pp.6, 2018, https://doi.org/10.3390/nu10060780
  2. Effect of egg consumption on inflammatory markers: a systematic review and meta‐analysis of randomized controlled clinical trials vol.99, pp.15, 2019, https://doi.org/10.1002/jsfa.9903
  3. Effect of Breed and Diet Type on the Freshness and Quality of the Eggs: A Comparison between Mos (Indigenous Galician Breed) and Isa Brown Hens vol.9, pp.3, 2020, https://doi.org/10.3390/foods9030342
  4. The effect of egg consumption on cardiometabolic health outcomes: an umbrella review vol.23, pp.5, 2018, https://doi.org/10.1017/s1368980019002441
  5. RNA Sequencing Reveals Key Metabolic Pathways Are Modified by Short-Term Whole Egg Consumption vol.8, pp.None, 2018, https://doi.org/10.3389/fnut.2021.652192
  6. Association between egg intake and blood pressure in the USA: the INTERnational study on MAcro/micronutrients and blood Pressure (INTERMAP) vol.24, pp.18, 2018, https://doi.org/10.1017/s1368980021002949
  7. Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study vol.11, pp.12, 2018, https://doi.org/10.1136/bmjopen-2021-050317
  8. Relationship between Egg Consumption and Body Composition as Well as Serum Cholesterol Level: Korea National Health and Nutrition Examination Survey 2008-2011 vol.10, pp.24, 2018, https://doi.org/10.3390/jcm10245918