Decreasing Particle Size of (+)-Dihydromyricetin Using Hydrophilic Polymer in Fractional Precipitation

분별침전에서 친수성 고분자 물질을 이용한 (+)-dihydromyricetin의 입자크기 감소

  • Ji, Seong Bin (Department of Chemical Engineering, Kongju National University) ;
  • Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
  • 지성빈 (공주대학교 화학공학부) ;
  • 김진현 (공주대학교 화학공학부)
  • Received : 2018.02.13
  • Accepted : 2018.05.01
  • Published : 2018.06.01


In this study, we have applied fractional precipitation with hydrophilic polymer in order to decrease the particle size of the (+)-dihydromyricetin from plant materials. When compared with the case where no hydrophilic polymer was employed, the addition of hydrophilic polymer in fractional precipitation resulted in a considerable decrease in the size of the (+)-dihydromyricetin precipitate. Among the polymers used, HPMC 2910 was the most effective for inhibition of precipitate growth. A polymer concentration of 0.1% (w/v) yielded the smallest particle size. The particle size was reduced by ~40% compared to control. In addition, the precipitate size was inversely correlated with the absolute value of the zeta potential of the suspension with polymer.


Supported by : 한국연구재단


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