Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Fractionated Stereotactic Radiosurgery for Brain Metastases Using the Novalis Tx® System

  • Lim, Tae Kyoo (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Woo Kyung (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine) ;
  • Yoo, Chan Jong (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Eun Young (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Myeong Jin (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine) ;
  • Yee, Gi Taek (Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine)
  • Received : 2017.12.29
  • Accepted : 2018.06.01
  • Published : 2018.07.01
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Abstract

Objective : To evaluate the efficacy of fractionated stereotactic radiosurgery (FSRS) performed using the Novalis $Tx^{(R)}$ system (BrainLAB AG, Feldkirchen, Germany; Varian Medical Systems, Palo Alto, CA, USA) for brain metastases. Methods : Between March 2013 and July 2016, 23 brain metastases patients were admitted at a single institute. Twenty-nine lesions too large for single session stereotactic radiosurgery or located in the vicinity of eloquent structures were treated by FSRS. Based on the results obtained, we reviewed the efficacy and toxicity of FSRS for the treatment of brain metastases. Results : The most common lesion origin was lung (55%) followed by breast (21%). Median overall survival was 10.0 months (95% confidence interval [CI], 4.9-15.0), and median progression-free survival was 10.0 months (95% CI, 2.1-13.9). Overall survival rates at 1 and 2 years were 58.6% and 36.0%, respectively. Local recurrence and neurological complications affecting morbidity each occurred in two cases. Conclusion : FSRS using the $Novalis-Tx^{(R)}$ system would appear to be an effective, safe noninvasive treatment modality for large and eloquently situated brain metastases. Further investigation is required on a larger number of patients.

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