Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-aging Effects of Sweroside Isolated from Nymphoides indica

어리연꽃으로부터 분리한 Sweroside의 항노화 효과

  • Kim, You Ah (Skin Science Research Institute, Kolmar Korea Co., Ltd.) ;
  • Kim, Dong Hee (Traditional Korean Medicine Technology Division, National Development Institute of Korean Medicine) ;
  • Park, Chae Bin (Skin Science Research Institute, Kolmar Korea Co., Ltd.) ;
  • Park, Tae Soon (Traditional Korean Medicine Technology Division, National Development Institute of Korean Medicine) ;
  • Park, Byoung Jun (Skin Science Research Institute, Kolmar Korea Co., Ltd.)
  • 김유아 (한국콜마(주) 피부과학연구소) ;
  • 김동희 (한약진흥재단 한의약기술본부) ;
  • 박채빈 (한국콜마(주) 피부과학연구소) ;
  • 박태순 (한약진흥재단 한의약기술본부) ;
  • 박병준 (한국콜마(주) 피부과학연구소)
  • Received : 2018.03.14
  • Accepted : 2018.05.28
  • Published : 2018.06.30
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Abstract

To develop a new functional agent for cosmetics, we investigated the anti-aging activities in fibroblasts using sweroside isolated from Nymphoides indica. The anti-aging effect of sweroside was validated in CCD-986sk cells. Results showed that sweroside inhibited expressions of UVB-induced ROS and increased pro-collagen. Furthermore, sweroside had inhibited MMP-1 expression. Taken together, the results suggested that sweroside has considerable potential as a new cosmetics ingredient with an anti-aging effect.

본 연구에서는 신규 기능성 화장품 소재 개발을 위해 어리연꽃으로부터 분리한 sweroside를 이용하여 섬유아세포 내에서의 항노화 효과를 확인하였다. CCD-986sk 세포를 이용하여 sweroside의 항노화 효과를 측정한 결과, UVB에 의해 증가된 ROS의 발현을 억제하였으며, pro-collagen의 발현을 증가시키며 MMP-1의 발현을 억제하는 것으로 확인되었다. 이 결과를 종합해보면, sweroside는 화장품 분야에서 신규 항노화 기능성 소재로서의 활용 가능성이 있는 것으로 판단된다.

Keywords

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