Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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GBCK25, fermented ginseng, attenuates cardiac dysfunction in high fat diet-induced obese mice

  • Sharmila, Judith (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Aravinthan, Adithan (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Shin, Dong Gue (Research Center, GeneralBio Co. Ltd., Jeonbuk Technopark R&D Support Center) ;
  • Seo, Jeong Hun (Research Center, GeneralBio Co. Ltd., Jeonbuk Technopark R&D Support Center) ;
  • Kim, Bumseok (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Kim, Nam Soo (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Kang, Chang-Won (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ;
  • Kim, Jong-Hoon (College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University)
  • Received : 2017.04.24
  • Accepted : 2017.05.12
  • Published : 2018.07.15
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Abstract

The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speeding up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, and echocardiographic studies. The results exhibited that body weights were significantly reduced and the gain of different organ weights were partly eased by GBCK25 treatment. Echocardiography results proposed the amelioration of heart function through normalized levels of left ventricle systolic pressure, ejection fraction, and fractional shortening. These outcomes deliver straight confirmation that GBCK25 could be a potential nutraceutical source for the relief of HFD-induced obesity mediated cardiac dysfunctions.

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References

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