References
- Mehendiratta M, Solomon MC, Boaz K, Guddattu V, Mohindra A. Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: an immunohistochemical study. J Oral Maxillofac Pathol 2014;18:217-22. https://doi.org/10.4103/0973-029X.140753
- Iglesias-Bartolome R, Martin D, Gutkind JS. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov 2013;3:722-5. https://doi.org/10.1158/2159-8290.CD-13-0239
- Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153-6. https://doi.org/10.1002/ijc.1440
- Xu Y, Fisher GJ. Role of met axis in head and neck cancer. Cancers (Basel) 2013;5:1601-18. https://doi.org/10.3390/cancers5041601
- Eiband JD, Elias EG, Suter CM, Gray WC, Didolkar MS. Prognostic factors in squamous cell carcinoma of the larynx. Am J Surg 1989;158:314-7. https://doi.org/10.1016/0002-9610(89)90123-2
- Tytor M, Olofsson J. Prognostic factors in oral cavity carcinomas. Acta Otolaryngol Suppl 1992;492:75-8.
- Stelow EB, Mills SE. Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol 2005;124 Suppl:S96-109.
- Noguchi M, Kido Y, Kubota H, Kinjo H, Kohama G. Prognostic factors and relative risk for survival in N1-3 oral squamous cell carcinoma: a multivariate analysis using Cox's hazard model. Br J Oral Maxillofac Surg 1999;37:433-7. https://doi.org/10.1054/bjom.1999.0146
- Rahima B, Shingaki S, Nagata M, Saito C. Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:423-31. https://doi.org/10.1016/j.tripleo.2003.10.014
- Woolgar JA, Rogers SN, Lowe D, Brown JS, Vaughan ED. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol 2003;39:130-7. https://doi.org/10.1016/S1368-8375(02)00030-1
- Puri SK, Fan CY, Hanna E. Significance of extracapsular lymph node metastases in patients with head and neck squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg 2003;11:119-23. https://doi.org/10.1097/00020840-200304000-00010
- Shingaki S, Takada M, Sasai K, Bibi R, Kobayashi T, Nomura T, et al. Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg 2003;185:278-84. https://doi.org/10.1016/S0002-9610(02)01378-8
- Close LG, Merkel M, Vuitch MF, Reisch J, Schaefer SD. Computed tomographic evaluation of regional lymph node involvement in cancer of the oral cavity and oropharynx. Head Neck 1989;11:309-17. https://doi.org/10.1002/hed.2880110405
- van den Brekel MW, Castelijns JA, Stel HV, Golding RP, Meyer CJ, Snow GB. Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study. Eur Arch Otorhinolaryngol 1993;250:11-7. https://doi.org/10.1007/BF00176941
- Takes RP, Baatenburg de Jong RJ, Wijffels K, Schuuring E, Litvinov SV, Hermans J, et al. Expression of genetic markers in lymph node metastases compared with their primary tumours in head and neck cancer. J Pathol 2001;194:298-302. https://doi.org/10.1002/1096-9896(200107)194:3<298::AID-PATH900>3.0.CO;2-Q
- Fidler IJ, Hart IR. Biological diversity in metastatic neoplasms: origins and implications. Science 1982;217:998-1003. https://doi.org/10.1126/science.7112116
- Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-9. https://doi.org/10.1038/25292
- Cortesina G, Martone T. Molecular metastases markers in head and neck squamous cell carcinoma: review of the literature. Acta Otorhinolaryngol Ital 2006;26:317-25.
- Belbin TJ, Singh B, Smith RV, Socci ND, Wreesmann VB, Sanchez-Carbayo M, et al. Molecular profiling of tumor progression in head and neck cancer. Arch Otolaryngol Head Neck Surg 2005;131:10-8. https://doi.org/10.1001/archotol.131.1.10
- Ren X, Wang J, Lin X, Wang X. E-cadherin expression and prognosis of head and neck squamous cell carcinoma: evidence from 19 published investigations. Onco Targets Ther 2016;9:2447-53.
- Chaw SY, Abdul Majeed A, Dalley AJ, Chan A, Stein S, Farah CS. Epithelial to mesenchymal transition (EMT) biomarkers--Ecadherin, beta-catenin, APC and vimentin--in oral squamous cell carcinogenesis and transformation. Oral Oncol 2012;48:997-1006. https://doi.org/10.1016/j.oraloncology.2012.05.011
- Rodrigo JP, Dominguez F, Alvarez C, Manrique C, Herrero A, Suarez C. Expression of E-cadherin in squamous cell carcinomas of the supraglottic larynx with correlations to clinicopathological features. Eur J Cancer 2002;38:1059-64. https://doi.org/10.1016/S0959-8049(01)00399-9
- Yokoyama K, Kamata N, Hayashi E, Hoteiya T, Ueda N, Fujimoto R, et al. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol 2001;37:65-71. https://doi.org/10.1016/S1368-8375(00)00059-2
- Suh Y, Amelio I, Guerrero Urbano T, Tavassoli M. Clinical update on cancer: molecular oncology of head and neck cancer. Cell Death Dis 2014;5:e1018. https://doi.org/10.1038/cddis.2013.548
- Lin RJ, Lubpairee T, Liu KY, Anderson DW, Durham S, Poh CF. Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer. J Otolaryngol Head Neck Surg 2013;42:23. https://doi.org/10.1186/1916-0216-42-23
- Gotte M, Kersting C, Radke I, Kiesel L, Wulfing P. An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ. Breast Cancer Res 2007;9:R8. https://doi.org/10.1186/bcr1641
- Scantlebury JB, Luo J, Thorstad WL, El-Mofty SK, Lewis JS Jr. Cyclin D1-a prognostic marker in oropharyngeal squamous cell carcinoma that is tightly associated with high-risk human papillomavirus status. Hum Pathol 2013;44:1672-80. https://doi.org/10.1016/j.humpath.2013.01.021
- Do NY, Park SY, Lim SC. The role of E-cadherin/beta-catenin complex and cyclin D1 in head and neck squamous cell carcinoma. Cancer Res Treat 2004;36:72-8. https://doi.org/10.4143/crt.2004.36.1.72
- Ahmed RA, Shawky Ael-A, Hamed RH. Prognostic significance of cyclin D1 and E-cadherin expression in laryngeal squamous cell carcinoma. Pathol Oncol Res 2014;20:625-33. https://doi.org/10.1007/s12253-014-9741-6
- Takes RP, Baatenburg De Jong RJ, Alles MJ, Meeuwis CA, Marres HA, Knegt PP, et al. Markers for nodal metastasis in head and neck squamous cell cancer. Arch Otolaryngol Head Neck Surg 2002;128:512-8. https://doi.org/10.1001/archotol.128.5.512
- Suresh TN, Hemalatha A, Harendra Kumar ML, Azeem Mohiyuddin SM. Evaluation of histomorphological and immunohistochemical parameters as biomarkers of cervical lymph node metastasis in squamous cell carcinoma of oral cavity: a retrospective study. J Oral Maxillofac Pathol 2015;19:18-24. https://doi.org/10.4103/0973-029X.157195
- Jiang WG. E-cadherin and its associated protein catenins, cancer invasion and metastasis. Br J Surg 1996;83:437-46. https://doi.org/10.1002/bjs.1800830404
- Akhtar K, Ara A, Siddiqui SA, Sherwani RK. Diagnostic and prognostic significance of E-cadherin and vimentin in oral cancer metastasis. Ann Pathol Lab Med 2016;3:A8-13.
- Kaur G, Carnelio S, Rao N, Rao L. Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study. Indian J Dent Res 2009;20:71-6. https://doi.org/10.4103/0970-9290.49075
-
Balasundaram P, Singh MK, Dinda AK, Thakar A, Yadav R. Study of
${\beta}$ -catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases. Diagn Pathol 2014;9:145. https://doi.org/10.1186/1746-1596-9-145 - Wang MB, Yip HT, Srivatsan ES. Antisense cyclin D1 enhances sensitivity of head and neck cancer cells to cisplatin. Laryngoscope 2001;111:982-8. https://doi.org/10.1097/00005537-200106000-00010
- Mattijssen V, Peters HM, Schalkwijk L, Manni JJ, van 't Hof-Grootenboer B, de Mulder PH, et al. E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int J Cancer 1993;55:580-5. https://doi.org/10.1002/ijc.2910550411
- Bankfalvi A, Krassort M, Vegh A, Felszeghy E, Piffko J. Deranged expression of the E-cadherin/beta-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas. J Oral Pathol Med 2002;31:450-7. https://doi.org/10.1034/j.1600-0714.2002.00147.x
- Shinohara M, Hiraki A, Ikebe T, Nakamura S, Kurahara S, Shirasuna K, et al. Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviour. J Pathol 1998;184:369-81. https://doi.org/10.1002/(SICI)1096-9896(199804)184:4<369::AID-PATH1236>3.0.CO;2-L
- Carlos de Vicente J, Herrero-Zapatero A, Fresno MF, Lopez-Arranz JS. Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance. Oral Oncol 2002;38:301-8. https://doi.org/10.1016/S1368-8375(01)00060-4
- Das SN, Khare P, Singh MK, Sharma SC. Correlation of cyclin D1 expression with aggressive DNA pattern in patients with tobaccorelated intraoral squamous cell carcinoma. Indian J Med Res 2011;133:381-6.
- Dhingra V, Verma J, Misra V, Srivastav S, Hasan F. Evaluation of cyclin D1 expression in head and neck squamous cell carcinoma. J Clin Diagn Res 2017;11:EC01-4. https://doi.org/10.1111/crj.12541
- Michalides RJ, van Veelen NM, Kristel PM, Hart AA, Loftus BM, Hilgers FJ, et al. Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 1997;123:497-502. https://doi.org/10.1001/archotol.1997.01900050045005
- Zhao Y, Yu D, Li H, Nie P, Zhu Y, Liu S, et al. Cyclin D1 overexpression is associated with poor clinicopathological outcome and survival in oral squamous cell carcinoma in Asian populations: insights from a meta-analysis. PLoS One 2014;9:e93210. https://doi.org/10.1371/journal.pone.0093210
- Saawarn S, Astekar M, Saawarn N, Dhakar N, Gomateshwar Sagari S. Cyclin d1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma. Scientific-WorldJournal 2012;2012:978327.
- Patel SB, Manjunatha BS, Shah V, Soni N, Sutariya R. Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia. J Korean Assoc Oral Maxillofac Surg 2017;43:324-30. https://doi.org/10.5125/jkaoms.2017.43.5.324