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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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With the greatest care, stromal interaction molecule (STIM) proteins verify what skeletal muscle is doing

  • Cho, Chung-Hyun (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Lee, Keon Jin (Department of Physiology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Eun Hui (Department of Physiology, College of Medicine, The Catholic University of Korea)
  • Received : 2018.04.11
  • Published : 2018.08.31
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Abstract

Skeletal muscle contracts or relaxes to maintain the body position and locomotion. For the contraction and relaxation of skeletal muscle, $Ca^{2+}$ in the cytosol of skeletal muscle fibers acts as a switch to turn on and off a series of contractile proteins. The cytosolic $Ca^{2+}$ level in skeletal muscle fibers is governed mainly by movements of $Ca^{2+}$ between the cytosol and the sarcoplasmic reticulum (SR). Store-operated $Ca^{2+}$ entry (SOCE), a $Ca^{2+}$ entryway from the extracellular space to the cytosol, has gained a significant amount of attention from muscle physiologists. Orai1 and stromal interaction molecule 1 (STIM1) are the main protein identities of SOCE. This mini-review focuses on the roles of STIM proteins and SOCE in the physiological and pathophysiological functions of skeletal muscle and in their correlations with recently identified proteins, as well as historical proteins that are known to mediate skeletal muscle function.

Keywords

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