대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
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Anti-obese related pharmacological effects of standard potato protein extracts on the 45%Kcal high fat diet supplied mice

  • Kang, Su-Jin (The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Song, Chang-Hyun (The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Jong-Kyu (Central Research Center, Aribio Co. Ltd.) ;
  • Chun, Yoon-Seok (Central Research Center, Aribio Co. Ltd.) ;
  • Han, Chang-Hyun (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Young-Joon (The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Ku, Sae-Kwang (The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University)
  • 투고 : 2018.08.08
  • 심사 : 2018.08.22
  • 발행 : 2018.08.31
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초록

Objectives : In present study, therefore, possible beneficial pharmacological activities of standard potato protein extracts (SPE) were observed on the mild diabetic obese mice. Methods : After end of 12 weeks of continuous oral administrations of three different dosages of SPE 400, 200 and 100 mg/kg, or metformin 250 mg/kg, analyzed the hepatoprotective, hypolipidemic, hypoglycemic, nephroprotective and anti-obesity effects, separately. In addition, liver antioxidant defense systems were additionally measured with lipid metabolism-related genes expressions and hepatic glucose-regulating enzyme activities for action mechanism. Results : All of diabetes and related complications including obesity were significantly inhibited by treatment of SPE 400, 200 and 100 mg/kg, dose-dependently, and they also dramatically normalized the hepatic lipid peroxidation and depletion of liver endogenous antioxidant defense system, the changes of the hepatic glucose-regulating enzyme activities, also changes of the lipid metabolism-related genes expressions including hepatic $AMPK{\alpha}1$ and $AMPK{\alpha}2$ mRNA expressions, dose-dependently. Especially, SPE 200 mg/kg constantly showed favorable inhibitory activities against type II diabetes and related complications as comparable to those of metformin 250 mg/kg in HFD mice, respectively. Conclusions : The present work demonstrated that SPE 400, 200 and 100 mg/kg showed favorable anti-diabetic and related complications including obesity refinement activities in HFD mice, through AMPK upregulation mediated hepatic glucose enzyme activity and lipid metabolism-related genes expression, antioxidant defense system and pancreatic lipid digestion enzyme modulatory activities.

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