Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Associations of Blood Lead and Cadmium Levels with Hypertension using the Korea National Health and Nutrition Examination Survey III-VI

국민건강영양조사 자료를 활용한 혈 중 납과 카드뮴의 고혈압과의 관련성

  • 서정욱 (동아대학교 환경보건센터) ;
  • 김병권 (동아대학교 환경보건센터) ;
  • 김유미 (동아대학교 환경보건센터) ;
  • 최병무 (동아대학교 의과대학 정신건강의학교실) ;
  • 서상민 (동아대학교 의과대학 정신건강의학교실) ;
  • 홍영습 (동아대학교 환경보건센터)
  • Received : 2018.07.23
  • Accepted : 2018.08.20
  • Published : 2018.08.28
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Abstract

Objective: A significant association between blood lead levels and hypertension has been reported in many studies. The relationship between cadmium and hypertension has been debated as well. We aimed to study the association of lead, cadmium, and both with hypertension in the Korean general population. Methods: We examined 5,967 adult men and 6,074 women who participated in the Korea National Health and Nutrition Examination Survey III-VI (2005, 2008-2013 years). Logistic regression models were used to examine the relationship between blood lead concentration and blood cadmium concentration and hypertension using logtransformed blood lead and cadmium concentrations as independent variables after covariate adjustment. Results: Adjusted for general characteristics, the odds ratio of log-lead to hypertension was 2.71 (1.82-4.03), and log-cadmium to hypertension was 2.52 (1.83-3.47). Estimates were found to be statistically significant (p<0.001). When a multiple logistic model was applied, the odds ratio of log-lead and log-cadmium for hypertension were 2.24 (1.50-3.36) and 2.24 (1.62-3.10), respectively. The standardized estimate coefficients of log-lead and logcadmium for hypertension were 4.77 and 6.65, respectively. Conclusion: We observed the association of blood lead concentration, blood cadmium concentration, and both with hypertension. This study suggests that exposure to lead and exposure to cadmium are both risk factors for hypertension.

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References

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