Allergy, Asthma & Immunology Research

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey

  • Kim, Mi-Ae (Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University) ;
  • Kim, Dong-Kyu (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Chuncheon Sacred Heart Hospital and Nano-Bio Regenerative Medical Institute, Hallym University College of Medicine) ;
  • Yang, Hyeon-Jong (Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine) ;
  • Yoo, Young (Department of Pediatrics, Korea University Anam Hospital) ;
  • Ahn, Youngmin (Department of Pediatrics Eulji Hospital, Eulji University) ;
  • Park, Hae-Sim (Department of Allergy and Clinical Immunology, Ajou University School of Medicine) ;
  • Lee, Hyun Jong (Lee & Hong ENT, Sleep and Cosmetic Center) ;
  • Jeong, Yi Yeong (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine) ;
  • Kim, Bong-Seong (Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Bae, Woo Yong (Department of Otorhinolaryngology, Head and Neck Surgery, Dong-A University College of Medicine) ;
  • Jang, An-Soo (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Park, Yang (Department of Pediatrics, Wonkwang University Sanbon Hospital, Wonkwang University College of Medicine) ;
  • Koh, Young-Il (Department of Internal Medicine, Chonnam National University Medical School & Hospital) ;
  • Lee, Jaechun (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Lim, Dae Hyun (Department of Pediatrics, Inha University Hospital, Inha University College of Medicine) ;
  • Kim, Jeong Hee (Department of Pediatrics, Inha University Hospital, Inha University College of Medicine) ;
  • Lee, Sang Min (Division of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine) ;
  • Kim, Yong Min (Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine) ;
  • Jun, Young Joon (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, SoonChunHayng University Hospital) ;
  • Kim, Hyo Yeol (Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Yunsun (SCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul Hospital) ;
  • Choi, Jeong-Hee (Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Clinical Immunology (Korean Academy of Asthma, Allergy and Clinical Immunology)
  • Received : 2018.04.08
  • Accepted : 2018.06.01
  • Published : 2018.11.01
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Abstract

Purpose: Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea. Methods: Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled. The questionnaires included demographic characteristics, a list of fruits and vegetables, and clinical manifestations of food allergy. Pollen allergy was diagnosed by skin prick test and/or measurement of the serum level of specific IgE. Results: A total of 648 pollinosis patients were enrolled. The prevalence of PFAS was 41.7% (n = 270). PFAS patients exhibited cutaneous (43.0%), respiratory (20.0%), cardiovascular (3.7%) or neurologic symptoms (4.8%) in addition to oropharyngeal symptoms. Anaphylaxis was noted in 8.9% of the PFAS patients. Seventy types of foods were linked to PFAS; e.g., peach (48.5%), apple (46.7%), kiwi (30.4%), peanut (17.4%), plum (16.3%), chestnut (14.8%), pineapple (13.7%), walnut (14.1%), Korean melon (12.6%), tomato (11.9%), melon (11.5%) and apricot (10.7%). Korean foods such as taro/taro stem (8.9%), ginseong (8.2%), perilla leaf (4.4%), bellflower root (4.4%), crown daisy (3.0%), deodeok (3.3%), kudzu root (3.0%) and lotus root (2.6%) were also linked to PFAS. Conclusions: This was the first nationwide study of PFAS in Korea. The prevalence of PFAS was 41.7%, and 8.9% of the PFAS patients had anaphylaxis. These results will provide clinically useful information to physicians.

Keywords

Acknowledgement

Supported by : Korean Academy of Asthma, Allergy, and Clinical Immunology

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