Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Anti-influenza properties of herbal extract of Althaea rosea in mice

촉규근 추출물에 의한 항인플루엔자 효능

  • Received : 2018.05.28
  • Accepted : 2018.07.27
  • Published : 2018.09.30
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Abstract

Althaea rosea has been used in traditional Chinese medicine to treat numerous diseases, but no studies have investigated its anti-influenza properties to date. In this study, we investigated the anti-influenza effects of Althaea rosea. BALB/c mice orally pretreated with Althaea rosea ($200{\mu}L$, 0.1 mg/mL concentration in phosphate-buffered saline) and followed by infection of influenza A virus nasally showed higher survivability and lower lung virus titer against divergent subtypes of influenza A virus infection. We also found that oral administration of Althaea rosea elicited antiviral innate immune responses in serum, bronchoalveolar lavage fluid, small intestinal fluid, and the lungs. Taken together, these findings suggest that aqueous extracts of Althaea rosea are a potential candidate for use as an anti-influenza drug.

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References

  1. Aballea S, Chancellor J, Martin M, Wutzler P, Carrat F, Gasparini R, Toniolo-Neto J, Drummond M, Weinstein M. The cost-effectiveness of influenza vaccination for people aged 50 to 64 years: an international model. Value Health 2007, 10, 98-116. https://doi.org/10.1111/j.1524-4733.2006.00157.x
  2. Abdel-Salam NA, Ghazy NM, Sallam SM, Radwan MM, Wanas AS, ElSohly MA, El-Demellawy MA, Abdel-Rahman NM, Piacente S, Shenouda ML. Flavonoids of Alcea rosea L. and their immune stimulant, antioxidant and cytotoxic activities on hepatocellular carcinoma HepG-2 cell line. Nat Prod Res 2018, 32, 702-706. https://doi.org/10.1080/14786419.2017.1332602
  3. Asres K, Bucar F, Kartnig T, Witvrouw M, Pannecouque C, De Clercq E. Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants. Phytother Res 2001, 15, 62-69. https://doi.org/10.1002/1099-1573(200102)15:1<62::AID-PTR956>3.0.CO;2-X
  4. Carr S, Ilyushina NA, Franks J, Adderson EE, Caniza M, Govorkova EA, Webster RG. Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer. Pediatr Infect Dis J 2011, 30, 284-288. https://doi.org/10.1097/INF.0b013e3181ff863b
  5. Deyde VM, Xu X, Bright RA, Shaw M, Smith CB, Zhang Y, Shu Y, Gubareva LV, Cox NJ, Klimov AI. Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis 2007, 196, 249-257. https://doi.org/10.1086/518936
  6. Dudek M, Mat awska I, Szkudlarek M. Phenolic acids in the flowers of Althaea rosea var. nigra. Acta Pol Pharm 2006, 63, 207-211.
  7. Kim YS, Kim EK, Nawarathna WPAS, Dong X, Shin WB, Park JS, Moon SH, Park PJ. Immune-stimulatory effects of Althaea rosea flower extracts through the MAPK signaling pathway in RAW264.7 cells. Molecules 2017, 22, 679. https://doi.org/10.3390/molecules22050679
  8. Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005, 4, 206-220. https://doi.org/10.1038/nrd1657
  9. Lefrancois L, Lycke N. Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr Protoc Immunol 2001, 17, 3.19.1-3.19.16.
  10. Lin LT, Hsu WC, Lin CC. Antiviral natural products and herbal medicines. J Tradit Complement Med 2014, 4, 24-35. https://doi.org/10.4103/2225-4110.124335
  11. Mantis NJ, Rol N, Corthesy B. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol 2011, 4, 603-611. https://doi.org/10.1038/mi.2011.41
  12. Muhetaer T, Resalat Y, Chu G, Yin X, Munira A. [Determination of rutin, quercetin and kaempferol in Althaea rosea (L) Gavan for Uyghur medicine by high performance liquid chromatography]. Se Pu 2015, 33, 1269-1273. Chinese.
  13. Price GE, Gaszewska-Mastarlarz A, Moskophidis D. The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice. J Virol 2000, 74, 3996-4003. https://doi.org/10.1128/JVI.74.9.3996-4003.2000
  14. Rahman M, Bright RA, Kieke BA, Donahue JG, Greenlee RT, Vandermause M, Balish A, Foust A, Cox NJ, Klimov AI, Shay DK, Belongia EA. Adamantane-resistant influenza infection during the 2004-05 season. Emerg Infect Dis 2008, 14, 173-176. https://doi.org/10.3201/eid1401.070460
  15. Viana ME, Coates NH, Gavett SH, Selgrade MK, Vesper SJ, Ward MDW. An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. Toxicol Sci 2002, 70, 98-109. https://doi.org/10.1093/toxsci/70.1.98