DOI QR코드

DOI QR Code

Effective Components of Bovine Colostrum and Its Applications

소 초유의 유효성분과 산업적 활용

  • Seo, Sang-Ah (Department of Stem Cell and Regenerative Biology, KIT, Konkuk University) ;
  • Seo, Hye-Ryoung (Department of Stem Cell and Regenerative Biology, KIT, Konkuk University) ;
  • Heo, Young-Tae (Department of Animal Science and Biotechnology, Sangji Youngseo College)
  • 서상아 (건국대학교 KU융합과학기술원 줄기세포재생공학과) ;
  • 서혜령 (건국대학교 KU융합과학기술원 줄기세포재생공학과) ;
  • 허영태 (상지영서대학교 동물생명산업과)
  • Received : 2018.08.27
  • Accepted : 2018.09.27
  • Published : 2018.09.30

Abstract

Bovine colostrum is necessary for newborn calves to survive, grow and receive immunity from their mother. Cows in Korea produce about 35kg of colostrum, 4Kg of which is fed to the calf, and the rest is discarded. The bovine colostrum causes the harmful side effects to human, such as allergies and digestive problems; so, it is prohibited by law to consume colostrum itself as a food. However, many scientific research data have suggested that components in the colostrum can improve human health and has the ability to help treat diseases. In line with the trend of food and pharmacy industries using natural product materials, which attract positive attention, recently, some ingredients in colostrum have been used in the production of food supplements, and it has been used in its raw form in some cosmetics. This review introduces the active ingredients and physiologically active substances contained in bovine colostrum, summarizes the efficacy of physiological enhancement of the colostrum, which has been proven by scientific methods to date, and also suggests the possibility of industrial applications of colostrum as an animal-derived natural material.

Keywords

References

  1. Afzal A, Mahmood MS, Hussain I and Akhtar M. 2011. Adulteration and microbiological quality of milk (a review). Pak. J. Nutr. 10:1195-1202. https://doi.org/10.3923/pjn.2011.1195.1202
  2. Ahn JH and Park JK. 2010. Effects of Supplementation of Fermented Colostrum on Growth and Occurrence of Diarrhea in Holstein Calves. J. Anim. Sci. and Tech. 52:281-286. https://doi.org/10.5187/JAST.2010.52.4.281
  3. Baek. 1992. 반추영양 2, 축산물이용, 초지; 젖소의 초유로부터의 immunoglobulin의 분리와 그 정량에 관한 연구. 한국축산학회 심포지움 자료집 1996:159-159.
  4. Bagwe S, Tharappel LJ, Kaur G and Buttar HS. 2015. Bovine colostrum: an emerging nutraceutical. J. Complement. Integr. Med. 12:175-185.
  5. Biswas P, Vecchi A, Mantegani P, Mantelli B, Fortis C and Lazzarin A. 2007. Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells. Microbiol. Q. J. Microbiol. Sci. 30:447-454.
  6. Bitzan MM, Gold BD, Philpott DJ, Huesca M, Sherman PM, Karch H, Lissner R, Lingwood CA and Karmali MA. 1998. Inhibition of Helicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. J. Infect. Dis, 177:955-961. https://doi.org/10.1086/515256
  7. Bourne FJ and Curtis J. 1973. The transfer of immunoglobulins IgG, IgA and IgM from serum to colostrum and milk in the sow. Immunology 24:157.
  8. Chopra I and Roberts M. 2001. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol. Rev. 65:232-260. https://doi.org/10.1128/MMBR.65.2.232-260.2001
  9. Floren CH, Chinenye S, Elfstrand L, Hagman C and Ihse I. 2006. ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoea. Scandinavian J. Gastro. 41:682-686. https://doi.org/10.1080/00365520500380817
  10. Francis GL, Read LC, Ballard FJ, Bagley CJ, Upton FM, Gravestock PM and Wallace JC. 1986. Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Biochem. J. 233:207-213. https://doi.org/10.1042/bj2330207
  11. Goldman AS and Smith CW. 1973. Host resistance factors in human milk. J. Pediatr. 82:1082-1090. https://doi.org/10.1016/S0022-3476(73)80453-6
  12. Grivennikov SI, Greten FR, and Karin M. 2010. Immunity, inflammation, and cancer. Cell 140:883-899. https://doi.org/10.1016/j.cell.2010.01.025
  13. Hironaka T. Ohishi H and Masaki T. 1997. Identification and partial purification of a basic fibroblast growth factor-like growth factor derived from bovine colostrum. J. Dairy Sci. 80:488-495. https://doi.org/10.3168/jds.S0022-0302(97)75961-7
  14. Iacopetta BJ, Grieu F, Horisberger M and Sunahara GI. 1992. Epidermal growth factor in human and bovine milk. Acta Paediatr. 81:287-291. https://doi.org/10.1111/j.1651-2227.1992.tb12227.x
  15. Juliano De Dea L, Marcela S, Yamaguishi CT and Soccol CR. 2011. Recovery and identification of bovine colostrum microflora using traditional and molecular approaches. Food Technol. Biotechnol. 49:364.
  16. Kaiser AG. 1977. The use of colostrum preserved with formalin for rearing calves. Aust. J. Exp. Agric. 17:221-223. https://doi.org/10.1071/EA9770221
  17. Klagsbrun M and Neumann J. 1979. The serum‐free growth of Balb/c 3T3 cells in medium supplemented with bovine colostrum. J. Supramolecular struct. 11:349-359. https://doi.org/10.1002/jss.400110310
  18. Klagsbrun M. 1980. Bovine colostrum supports the serum-free proliferation of epithelial cells but not of fibroblasts in long-term culture. J. Cell Biol. 84:808-814. https://doi.org/10.1083/jcb.84.3.808
  19. Korhonen H and Pihlanto A. 2007. Technological options for the production of health-promoting proteins and peptides derived from milk and colostrum. Curr. Pharm. Des. 13:829-843. https://doi.org/10.2174/138161207780363112
  20. Kovacs D, Cardinali G, Aspite N and Picardo M. 2009. Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line. Growth Factors 27:448-455. https://doi.org/10.3109/08977190903211077
  21. Lee CW and Kim YK. 1988. Some Physicochemical Properties of Bovine Colostral Casein Micelles. Korean J. Food Sci. Technol. 20:170-175.
  22. Lehto E, Salminen S and Aalto J. 1995. Colostrum as an ingredient for functional foods. Intl. Food Ingredients 2:19-20.
  23. Lima SF, Teixeira AGV, Lima FS, Ganda EK, Higgins CH, Oikonomou G and Bicalho RC. 2017. The bovine colostrum microbiome and its association with clinical mastitis. J. Dairy Sci. 100:3031-3042. https://doi.org/10.3168/jds.2016-11604
  24. Lu RR, Shi YX, Zhang W and Rui JY. 2007. Isolation of lactoferrin from bovine colostrum by ultrafiltration coupled with strong cation exchange chromatography on a production scale. J. Membr. Sci. 297:152-161. https://doi.org/10.1016/j.memsci.2007.03.039
  25. Macy IG. 1949. Composition of human colostrum and milk. Am. J. Dis. Children. 78:589-603.
  26. Mahmood A, FitzGerald AJ, Marchbank T, Ntatsaki E, Murray D, Ghosh S and Playford RJ. 2007. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut 56:168-175. https://doi.org/10.1136/gut.2006.099929
  27. Moody EG, Wise GH, Parrish DB and Atkeson FW. 1951. Properties of the Colostrum of the Dairy Cow. VI. Creaming and Rate of Flow1. J. Dairy Sci. 34:106-115. https://doi.org/10.3168/jds.S0022-0302(51)91678-5
  28. Morris JA, Wray C and Sojka WJ. 1980. Passive protection of lambs against enteropathogenic Escherichia coli: role of antibodies in serum and colostrum of dams vaccinated with K99 antigen. J. Med. Microbiol. 13:265-272. https://doi.org/10.1099/00222615-13-2-265
  29. Nam MS and Bae HC. 2009. Effects of Feeding Bovine Colostrum on Growth and Feed Intake of Mouse. Korean J. Agric. Sci. 36:179-184.
  30. Nam MS. 2002. Purification of TGF-${\beta}1$ from bovine colostrums. Korean J. Food Sci. Ani. Resour, 22:343-347.
  31. Nitsch A and Nitsch FP. 1998. The clinical use of bovine colostrum. J. orthomolecular Med. 13:110-118.
  32. Ogra SS, Weintraub D and Ogra PL. 1977. Immunologic aspects of human colostrum and milk: III. Fate and absorption of cellular and soluble components in the gastrointestinal tract of the newborn. J. Immunol. 119:245-248.
  33. Pakkanen R and Aalto J. 1997. Growth factors and antimicrobial factors of bovine colostrum. Int. Dairy J. 7:285-297. https://doi.org/10.1016/S0958-6946(97)00022-8
  34. Parrish DB, Wise GH and Hughes JS. 1949. Properties of the Colostrum of the Dairy Cow. IV. Effect of Form of Vitamin A and of Tocopherol Supplements on Concentrations of Vitamin A and Carotenoids1. J. Dairy Sci. 32:458-464. https://doi.org/10.3168/jds.S0022-0302(49)92065-2
  35. Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA and Marchbank T. 1999. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 44:653-658. https://doi.org/10.1136/gut.44.5.653
  36. Playford RJ, Macdonald CE and Johnson WS. 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am. J. Clin. Nutr. 72:5-14. https://doi.org/10.1093/ajcn/72.1.5
  37. Rathe M, Müller K, Sangild PT and Husby S. 2014. Clinical applications of bovine colostrum therapy: a systematic review. Nutr. Rev. 72:237-254. https://doi.org/10.1111/nure.12089
  38. Reiter B and Brock JH. 1975. Inhibition of Escherichia coli by bovine colostrum and post-colostral milk. I. Complement-mediated bactericidal activity of antibodies to a serum susceptible strain of E. coli of the serotype O 111. Immunol. 28:71.
  39. Roy JHB. 1969. The nutrition of the dairy calf. In International encyclopedia of food and nutrition, D. Cuthbertson(Ed). Vol 17, Part 2, Assessment of and factors affecting requirements of farm livestock. Pergamon Press, London, U.K., p. 645.
  40. Sabin AB and Fieldsteel AH. 1962. Antipoliomyelitic activity of human and bovine colostrum and milk. Pediatr. 29:105-115.
  41. Sacerdote P, Mussano F, Franchi S, Panerai AE, Bussolati G, Carossa S, Bartorelli A and Bussolati B. 2013. Biological components in a standardized derivative of bovine colostrum. J. Dairy Sci. 96:1745-1754. https://doi.org/10.3168/jds.2012-5928
  42. Sandholm M and Honkanen-Buzalski T. 1979. Colostral trypsin-inhibitor capacity in different animal species. Acta Vet. Scand. 20:469-476.
  43. Sarker SA, Casswall TH, Mahalanabis D, Alam NH, Albert MJ, Brussow H, Fuchs GJ and Hammerstrom L. 1998. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr. Infect. Dis. J. 17:1149-1154. https://doi.org/10.1097/00006454-199812000-00010
  44. Seth R and Das A. 2011. Colostrum powder and its health benefits. Chemical analysis of value added dairy products and their quality assurance, India, pp. 59-67.
  45. Shah NP. 2000. Effects of milk-derived bioactives: an overview. Br. J. Nutr. 84:3-10.
  46. Silva SV and Malcata FX. 2005. Caseins as source of bioactive peptides. Int. Dairy J. 15:1-15. https://doi.org/10.1016/j.idairyj.2004.04.009
  47. Steimer KS, Packard R, Holden D and Klagsbrun M. 1981. The serum‐free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period. Journal of cellular physiology 109:223-234. https://doi.org/10.1002/jcp.1041090205
  48. Stelwagen K, Carpenter E, Haigh B, Hodgkinson A and Wheeler TT. 2009. Immune components of bovine colostrum and milk. J. Anim. Sci. 87:3-9. https://doi.org/10.2527/jas.2008-1377
  49. Stewart S, Godden S, Bey R, Rapnicki P, Fetrow J, Farnsworth R, Scanlon M, Arnold Y, Clow L, Mueller K and Ferrouillet C. 2005. Preventing bacterial contamination and proliferation during the harvest, storage, and feeding of fresh bovine colostrum. J. Dairy Sci. 88:2571-2578. https://doi.org/10.3168/jds.S0022-0302(05)72933-7
  50. Tokuyama H, Tokuyama Y and Migita S. 1990. Isolation of two new proteins from bovine colostrum which stimulate epidermal growth factor-dependent colony formation of NRK-49F cells. Growth Factors 3:105-114. https://doi.org/10.3109/08977199009108273
  51. Tripathi V and Vashishtha B. 2006. Bioactive compounds of colostrum and its application. Food Reviews Int. 22:225-244. https://doi.org/10.1080/87559120600694606
  52. Uruakpa FO, Ismond MAH and Akobundu ENT. 2002. Colostrum and its benefits: a review. Nutr. Res. 22:755-767. https://doi.org/10.1016/S0271-5317(02)00373-1
  53. Van Hooijdonk AC, Kussendrager KD and Steijns JM. 2000. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br. J. Nutr., 84:127-134.
  54. Wheeler TT, Hodgkinson AJ, Prosser CG and Davis SR. 2007. Immune components of colostrum and milk-a historical perspective. J. Mammary Gland Biol. Neoplasia, 12:237-247. https://doi.org/10.1007/s10911-007-9051-7
  55. Wong EB, Mallet JF, Duarte J, Matar C and Ritz BW. 2014. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutr. Res. 34:318-325. https://doi.org/10.1016/j.nutres.2014.02.007
  56. Xu ML, Kim HJ and Kim HJ. 2014. Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide. Arch. Pharmacal Res. 37:494-500. https://doi.org/10.1007/s12272-013-0255-7
  57. Xu ML, Kim HJ, Chang DY and Kim HJ. 2013. The effect of dietary intake of the acidic protein fraction of bovine colostrum on influenza A (H1N1) virus infection. J. Microbiol. 51:389-393. https://doi.org/10.1007/s12275-013-2683-y
  58. Yoshida S, Wei Z, Shinmura Y and Fukunaga N. 2000. Separation of lactoferrin-a and-b from bovine colostrum. J. Dairy Sci. 83:2211-2215. https://doi.org/10.3168/jds.S0022-0302(00)75104-6