Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
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Effects of KIOM-79 on streptozotocin-induced insulin-dependent diabetes in Sprague-Dawley rats

Streptozotocin을 이용한 제1형 당뇨 유발 흰쥐에서 KIOM-79의 효과

  • Lee, Jong Hyuk (Medical course, School of Medicine, Jeju National University) ;
  • Yoon, Sang-Pil (Department of Anatomy, School of Medicine, Jeju National University) ;
  • Kim, Jin-Sook (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Chang, In-Youb (Department of Anatomy, School of Medicine, Chosun University)
  • 이종혁 (제주대학교 의학전문대학원 의학과) ;
  • 윤상필 (제주대학교 의학전문대학원 해부학교실) ;
  • 김진숙 (한국한의학연구원 한약연구부) ;
  • 장인엽 (조선대학교 의과대학 해부학교실)
  • Received : 2018.10.23
  • Accepted : 2018.11.07
  • Published : 2018.12.31
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Abstract

We investigated the effect of KIOM-79, 80% ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg/day) 1) for 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks after establishing diabetes model to examine acute and chronic effects on hyperglycemia and biochemical variables, respectively. As a result, KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced insulin-dependent diabetes although it has been known to have hypoglycemic and antidiabetic effects on non-insulin-dependent diabetes models.

Keywords

References

  1. Korean Diabetes Association. Diabetes fact sheet in Korea 2018. Korean Diabetes Association. 2018. P 1-40. Available from: URL http://www.diabetes.or.kr/pro/news/admin.php?category=A&code=admin&number=1546&mode=view
  2. Son AH, Koh JY, Lee DK, Shin HS. Review of domestic experimental studies of Korean medicine treatment for diabetes mellitus since 2013. J Int Korean Med 2017;38:10-9. https://doi.org/10.22246/jikm.2017.38.1.10
  3. Kim JS, Jang DS, Jeon YJ, You HJ, Park KH, Ming J, et al. Inhibition of p65 nuclear translocation by KIOM-79. Kor J Anat 2006;39:103-10.
  4. Wang JP, Hsu MF, Raung SI, Chen CC, Kuo JS, Teng CM. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol 1992:346;707-12.
  5. Miyazawa M, Sakano K, Nakamura S, Kosaka H. Antimutagenic activity of isolfavone from Pueraria lobata. J Agric Food Chem 2001;49:336-41. https://doi.org/10.1021/jf000255w
  6. Lee KT, Sohn IC, Kim YK, Choi JH, Choi JW, Park HJ, et al. Tectorigenin, an isoflavone of Pueraria thunbergiana BENTH., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull 2001;24:1117-21. https://doi.org/10.1248/bpb.24.1117
  7. Wang ZY, Nixon DW. Licorice and cancer. Nutr Cancer 2001;39:1-11. https://doi.org/10.1207/S15327914nc391_1
  8. Kang KA, Lee KH, Kim SY, Kim HS, Kim JS, Hyun JW. Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1. Biol Pharm Bull 2007;30:852-8. https://doi.org/10.1248/bpb.30.852
  9. Kang KA, Kim JS, Zhang R, Piao MJ, Ko DO, Wang ZH, et al. Induction of heme oxygenase-1 by plant extract KIOM-79 via Akt pathway and NF-E2 related factor 2 in pancreatic beta-cells. J Toxicol Environ Health A 2008;71:1392-9. https://doi.org/10.1080/15287390802271624
  10. Kang KA, Kim JS, Zhang R, Piao MJ, Ko DO, Wang ZH, et al. Effect of KIOM-79 against mitochondrial damage induced by streptozotocin in pancreatic beta-cells. J Toxicol Environ Health A 2009;72:1201-8. https://doi.org/10.1080/15287390903127071
  11. Jung DH, Kim YS, Kim JS. KIOM-79 prevents S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells. J Ethnophamacol 2009;125:374-9. https://doi.org/10.1016/j.jep.2009.08.002
  12. Kim DH, Park SC, Lee JH, Lee HY, Cho MK, Choi JY, et al. Recent research trends in Korean medicine treatment of diabetes mellitus - Focusing on domestic articles from 2008 to 2013. Korean J Orient Int Med 2013;34:240-55.
  13. Ku YP, Jin M, Kim KH, Ahn YJ, Yoon SP, You HJ, et al. Immunolocalization of 8-OHdG and OGG1 in pancreatic islets of streptozotocin-induced diabetic rats. Acta Histochem 2009;111:138-44. https://doi.org/10.1016/j.acthis.2008.05.008
  14. Kim JN, Chang IY, Kim HI, Yoon SP. Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic rats. Islets 2009;1:111-6. https://doi.org/10.4161/isl.1.2.9143
  15. Kalkhoff RK, Jacobson M, Lemper D. Progesterone, pregnancy and the augmented plasma insulin response. J Clin Endocrinol Metab 1970;31:24-8. https://doi.org/10.1210/jcem-31-1-24
  16. Diamond MP, Simonson DC, DeFronzo RA. Menstrual cyclicity has a profound effect on glucose homeostasis. Fertil Steril 1989;52:204-8. https://doi.org/10.1016/S0015-0282(16)60842-7
  17. El Seifi S, Green IC, Perrin D. Insulin release and steroid-hormone binding isolated islets of Langerhans in the rat: effects of ovariectomy. J Endocrinol 1981;90:59-67. https://doi.org/10.1677/joe.0.0900059
  18. Kim JW, Lee KJ, Yoon SP. Sexual comparison of decreased postprandial glucose concentration with chitosan-oligosaccharides. J Chitin Chitosan 2007;12:222-7.
  19. Kim CS, Sohn EJ, Kim YS, Jung DH, Jang DS, Lee YM, et al. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J Ethnopharm 2007;111:240-7. https://doi.org/10.1016/j.jep.2006.11.023
  20. Kim YS, Kim J, Kim CS, Sohn EJ, Lee YM, Jeong IH, et al. KIOM-79, an inhibitor of AGEs-protein cross-linking, prevents progression of nephropathy in Zucker diabetic fatty rats. Evid Based Complement Alternat Med 2011;1:761859.