Journal of Chitin and Chitosan (한국키틴키토산학회지)

The Korean Society for Chitin and Chitosan (한국키틴키토산학회)
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Quantum Dot and Iron Oxide Nanoparticle-Loaded Chitosan Nanoparticles for Cancer Imaging

양자점과 산화철 나노입자가 함유된 키토산 나노입자를 이용한 암 영상화 연구

  • Kim, Min Ah (Department of Biomedical Engineering, Chonnam National University Graduated School) ;
  • Jeong, Hwan-Jeong (Department of Nuclear Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School) ;
  • Lee, Chang-Moon (Department of Biomedical Engineering, Chonnam National University Graduated School)
  • 김민아 (전남대학교 바이오메디컬공학협동과정) ;
  • 정환정 (전북대학교병원 핵의학과) ;
  • 이창문 (전남대학교 바이오메디컬공학협동과정)
  • Received : 2018.08.10
  • Accepted : 2018.08.16
  • Published : 2018.09.30
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Abstract

In this study, we report superparamagnetic iron oxide nanoparticles (SPION) and quantum dots (Q-Dots)-loaded glycol chitosan (GC) nanoparticles as a dual imaging probe for tumor imaging. From GC modified with histidine self-assembled GC nanoparticles containing SPION and Q-Dots were prepared as a dual imaging probe. Tumor accumulation of the GC nanoparticles was investigated through optical and magnetic resonance imaging in a MDA-MB231 breast mouse cancer model. The SPION and Q-Dots-loaded GC nanoparticles were successfully accumulated into tumor by prolonged circulation and enhanced permeability and retention effect. As expected, in ex vivo study, the SPION and Q-Dots-loaded GC nanoparticles showed higher uptake in tumor than the other organs. The SPION and Q-Dots-loaded GC nanoparticles are a promising imaging agent for cancer imaging and can be used as a cancer-targeted drug delivery for chemotherapy.

본 연구에서는 종양을 영상화하기 위해 SPION과 Q-Dots을 함유한 NAHis-GC 나노입자를 제조하고 형태와 크기 측정 및 종양 내 축적을 optical imaging 및 MR imaging을 통해 다음과 같은 결과를 얻었다. NAHis-GC는자기조립나노입자가형성되었고소수성코어 부분에 SPION과 Q-Dots을 성공적으로 로딩되었다. SPION과 Q-Dots을 함유한 NAHis-GC 나노입자는 EPR 효과에 의해 종양조직에 축적되었고 두 가지 optical imaging과 MR imaging을 동시에 수행할 수 있었다. 이러한 결과를 통해, SPION과 Q-Dots을 함유한 NAHis-GC 나노입자는 optical imaging과 MR imaging 조영제로써 사용 가능성이 있고 더 나아가 약물을 함께 전달할 수 있어서 테라노스틱 제제로 유용할 것이다.

Keywords

Acknowledgement

Supported by : 한국연구재단

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