DOI QR코드

DOI QR Code

Studies and proposals of childhood asthma in Korea

한국의 소아 천식의 연구 현황과 과제

  • Kim, Woo Kyung (Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine)
  • 김우경 (인제대학교 의과대학 서울백병원 소아청소년과)
  • Received : 2017.12.23
  • Accepted : 2018.07.10
  • Published : 2018.09.30

Abstract

This review mainly focuses on the academy and research group published on childhood asthma and aims to investigate the impact of Korean study results in this field. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires have shown that the prevalence of childhood asthma is increasing worldwide. The ISAAC, which Korea joined in 1995, has enabled us to compare prevalence between countries. Korea has participated in three ISAAC surveys: 3 nationwide surveys in 1995, 2000, and 2010. The 12-month prevalence of asthma symptoms from the questionnaires was 4.9%-10.1% for children aged 6-7 years. In Korea, ISAAC surveys demonstrated that risk factors for asthma are obesity, secondhand smoking, diet patterns, raising pets, fever in infancy, and the use of antibiotics. However, because these were large-scale but cross-sectional studies, prospective cohort studies on growth patterns from prenatal through postnatal periods are needed to elucidate accurate risk factors. In 2016, 2 research groups were united to Korea childhood Asthma RESearch (KARES). Several studies were published from KARES. We reported prevalence of each asthma severity category and the controller prescription patterns according to asthma severity assessed by a Western (Global Initiative for Asthma) and an Asia-Pacific (Japanese Pediatric GuideLine) guideline were evaluated. And we translate the Test for Respiratory and Asthma Control in Kids instrument into Korean, with subsequent linguistic validation. The role of the Korean Academy of Pediatric Allergy and Respiratory Disease will be important for the prevent the child and adolescent asthma through the various Korean child data made.

Keywords

References

  1. Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8:483-91. https://doi.org/10.1183/09031936.95.08030483
  2. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368: 733-43. https://doi.org/10.1016/S0140-6736(06)69283-0
  3. Hong SJ, Lee MS, Sohn MH, Shim JY, Han YS, Park KS, et al. Self-reported prevalence and risk factors of asthma among Korean adolescents: 5- year follow-up study, 1995-2000. Clin Exp Allergy 2004;34:1556-62. https://doi.org/10.1111/j.1365-2222.2004.02084.x
  4. Ahn K, Kim J, Kwon HJ, Chae Y, Hahm MI, Lee KJ, et al. The prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in Korean children: nationwide cross-sectional survey using complex sampling design. J Korean Med Assoc 2011;54:769-78. https://doi.org/10.5124/jkma.2011.54.7.769
  5. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, et al. Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey. J Korean Med Sci 2001;16:155-64. https://doi.org/10.3346/jkms.2001.16.2.155
  6. Cha JK, Oh JW, Hong SJ, Lee HR, Lee MI, Kim KE, et al. Development and multicenter study on Korean pediatric asthma caregiver's quality of life questionnaire (KPACQLQ). J Asthma Allergy Clin Immunol 2000; 20:480-91.
  7. Kim MS, Kim YH, Suh DI, Koh YY, Kim BJ, Kim HB, et al. The prevalence of bronchial hyperresponsiveness in elementary school children and its associated factors. Allergy Asthma Respir Dis 2014;2:171-8. https://doi.org/10.4168/aard.2014.2.3.171
  8. Kim YY, Cho SH, Kim WK, Park JK, Song SH, Kim YK, et al. Prevalence of childhood asthma based on questionnaires and methacholine bronchial provocation test in Korea. Clin Exp Allergy 1997;27:761-8. https://doi.org/10.1046/j.1365-2222.1997.710839.x
  9. Kwon JW, Kim BJ, Song Y, Seo JH, Kim TH, Yu J, et al. Changes in the prevalence of childhood asthma in seoul from 1995 to 2008 and its risk factors. Allergy Asthma Immunol Res 2011;3:27-33. https://doi.org/10.4168/aair.2011.3.1.27
  10. Lee Y, Choi J, Park MR, Kim J, Kim WK, Park YM, et al. Analysis of regional prevalence of allergic diseases in Korean school children. Allergy Asthma Respir Dis 2015;3:62-9. https://doi.org/10.4168/aard.2015.3.1.62
  11. Park JJ, Kim JJ, Kang IJ. The risk factors for persistence of asthma symptoms from late childhood to early adult life: the effects of pulmonary function and bronchial hyperresponsiveness. Pediatr Allergy Respir Dis 2008;18:138-47.
  12. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009;64:476-83. https://doi.org/10.1136/thx.2008.106609
  13. Korea Centers for Disease Control and Prevention. Investigation of the reference ranges of respiratory and allergic diseases test based on disease diagnosis in nationwide randomized general pediatric population. Cheongju (Korea): Korea Centers for Disease Control and Prevention, 2015.
  14. Korea Centers for Disease Control and Prevention. Standardization study or the diagnosis and treatment of pediatric allergic diseases. Cheongju (Korea): Korea Centers for Disease Control and Prevention, 2010.
  15. Clifford RD, Pugsley A, Radford M, Holgate ST. Symptoms, atopy, and bronchial response to methacholine in parents with asthma and their children. Arch Dis Child 1987;62:66-73. https://doi.org/10.1136/adc.62.1.66
  16. Townley RG, Bewtra A, Wilson AF, Hopp RJ, Elston RC, Nair N, et al. Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. J Allergy Clin Immunol 1986;77(1 Pt 1):101-7. https://doi.org/10.1016/0091-6749(86)90330-1
  17. Hopp RJ, Bewtra AK, Nair NM, Watt GD, Townley RG. Methacholine inhalation challenge studies in a selected pediatric population. Am Rev Respir Dis 1986;134:994-8. https://doi.org/10.1164/arrd.1986.134.5.994
  18. Hopp RJ, Bewtra AK, Watt GD, Nair NM, Townley RG. Genetic analysis of allergic disease in twins. J Allergy Clin Immunol 1984;73:265-70. https://doi.org/10.1016/S0091-6749(84)80018-4
  19. Kim YK, Cho SH, Koh YY, Son JW, Jee YK, Lee MH, et al. Skin reactivity to inhalant allergens, total serum IgE levels, and bronchial responsiveness to methacholine are increased in parents of nonatopic asthmatic children. J Allergy Clin Immunol 1999;104(2 Pt 1):311-6. https://doi.org/10.1016/S0091-6749(99)70372-6
  20. Johnston SL. Natural and experimental rhinovirus infections of the lower respiratory tract. Am J Respir Crit Care Med 1995;152(4 Pt 2):S46-52. https://doi.org/10.1164/ajrccm/152.4_Pt_2.S46
  21. Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 1999;159:785-90. https://doi.org/10.1164/ajrccm.159.3.9801052
  22. Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LE, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010;125:1001-6.e1. https://doi.org/10.1016/j.jaci.2010.01.059
  23. Corne JM, Lau L, Scott SJ, Davies R, Johnston SL, Howarth PH. The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection. Am J Respir Crit Care Med 2001;163:1101-7. https://doi.org/10.1164/ajrccm.163.5.9902047
  24. Johnston NW, Sears MR. Asthma exacerbations. 1: epidemiology. Thorax 2006;61:722-8. https://doi.org/10.1136/thx.2005.045161
  25. Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201:937-47. https://doi.org/10.1084/jem.20041901
  26. Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, et al. Induced sputum 8-isoprostane concentrations in inflammatory airway diseases. Am J Respir Crit Care Med 2005;171:426-30. https://doi.org/10.1164/rccm.200408-1010OC
  27. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia 2004; 47(Suppl 1):A1-464. https://doi.org/10.1007/BF03375463
  28. Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A, et al. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ 2002;324:763.
  29. Kondo S, Ito M, Saito M, Sugimori M, Watanabe H. Progressive bronchial obstruction during the acute stage of respiratory tract infection in asthmatic children. Chest 1994;106:100-4. https://doi.org/10.1378/chest.106.1.100
  30. Chang YT, Yang YH, Chiang BL. The significance of a rapid cold hemagglutination test for detecting mycoplasma infections in children with asthma exacerbation. J Microbiol Immunol Infect 2006;39:28-32.
  31. Yamashita R, Kitahara H, Kanemitsu T, Takeda T, Yamaguchi S. Eosinophil cationic protein in the sera of patients with Mycoplasma pneumonia. Pediatr Infect Dis J 1994;13:379-81. https://doi.org/10.1097/00006454-199405000-00009
  32. Kondo N, Nishimuta T, Nishima S, Morikawa A, Aihara Y, Akasaka T, et al. Japanese pediatric guidelines for the treatment and management of bronchial asthma 2008. Pediatr Int 2010;52:319-26. https://doi.org/10.1111/j.1442-200X.2009.03010.x
  33. The Global Initiative for Asthma. 2006 Revision: GINA report, global strategy for asthma management and prevention [Internet]. The Global Initiative for Asthma; 2007 [cited 2017 Dec 22]. Available from: http://www. who.int/respiratory/asthma/GINA_WR_2006_copyright%5B1%5D.pdf.
  34. Suh DI, Yang HJ, Kim BS, Shin YH, Lee SY, Park G, et al. Asthma severity and the controller prescription in children at 12 tertiary hospitals. Allergy Asthma Immunol Res 2017;9:52-60. https://doi.org/10.4168/aair.2017.9.1.52
  35. Oh HL, Koh YY, Suh DI, Kang BC, Kim BS, Kim WK, et al. Translation and linguistic validation of Korean version of the Test for Respiratory and Asthma Control in kids instrument. Allergy Asthma Respir Dis 2016;4: 22-30. https://doi.org/10.4168/aard.2016.4.1.22
  36. Suh M, Kim HH, Sohn MH, Kim KE, Kim C, Shin DC. Prevalence of allergic diseases among Korean school-age children: a nationwide cross-sectional questionnaire study. J Korean Med Sci 2011;26:332-8. https://doi.org/10.3346/jkms.2011.26.3.332