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Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder

  • Moon, Eunsoo (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Choe, Byeong-Moo (Department of Psychiatry, Dong-A University School of Medicine) ;
  • Park, Je-Min (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Chung, Young In (Department of Psychiatry, Pusan National University School of Medicine) ;
  • Lee, Byung Dae (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Park, Jae-Hong (Department of Psychiatry, Dong-A University School of Medicine) ;
  • Lee, Young Min (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Jeong, Hee Jeong (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Cheon, YongJun (Department of Psychiatry, Dongrae Hospital) ;
  • Choi, Yoonmi (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital) ;
  • Park, Jeonghyun (Department of Psychiatry and Medical Research Institute, Pusan National University Hospital)
  • Received : 2018.04.03
  • Accepted : 2018.05.23
  • Published : 2018.09.30

Abstract

Objective Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpirole-induced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. Methods The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. Results The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. Conclusion These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern.

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