DOI QR코드

DOI QR Code

Literature Review on Herbal Medicine Treatment of Psoriasis Based on Chronic Low-grade Inflammation Theory

만성 저등급 염증이론을 바탕으로 한 건선의 한약치료에 대한 문헌고찰

  • Received : 2018.10.09
  • Accepted : 2018.11.07
  • Published : 2018.11.25

Abstract

Objectives : The aim of this study is to investigate the relationship between chronic low grade inflammation theory, psoriasis, and herbal medicine. Methods : We reviewed recent studies on the relationship between chronic low-grade inflammation, psoriasis, and herbal medicine through Pubmed. Results : The pathological basis for psoriasis is the action of inflammatory mediators by the activation of the immune response, which can be a cause of various cardiovascular, metabolic and psychological symptoms of psoriasis patients, in addition to skin lesions. The herbal medicines improve these inflammatory conditions and improve local lesions through herbal medicine such as Qingdai, which have a strong inhibitory effect on IL-17,22 production. Conclusions : Herbal medicines used in psoriasis are thought to be effective not only for the improvement of local psoriasis lesions through anti-inflammatory effect but also for the improvement of systemic inflammation associated with chronic low grade inflammation.

Keywords

References

  1. Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141(12):1537-41. https://doi.org/10.1001/archderm.141.12.1537
  2. Kremers HM, McEvoy MT, Dann FJ, Gabriel SE. Heart disease in psoriasis. J Am Acad Dermatol. 2007;57(2):347-54. https://doi.org/10.1016/j.jaad.2007.02.007
  3. Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55(5):829-35. https://doi.org/10.1016/j.jaad.2006.08.040
  4. Heymann WR. Psoriasis: the heart of the matter. J Am Acad Dermatol. 2008;58(3):477-8. https://doi.org/10.1016/j.jaad.2007.07.043
  5. Griffiths CE, Katsambas A, Dijkmans BA, Finlay AY, Ho VC, Johnston A, et al. Update on the use of ciclosporin in immune-mediated dermatoses. Br J Dermatol. 2006;155 Suppl 2:1-16.
  6. Gelfand JM, Gladman DD, Mease PJ, Smith N, Margolis DJ, Nijsten T, et al. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol. 2005;53(4):573.
  7. Strober B, Teller C, Yamauchi P, Miller JL, Hooper M, Yang YC, et al. Effects of etanercept on C-reactive protein levels in psoriasis and psoriatic arthritis. Br J Dermatol. 2008;159(2):322-30. https://doi.org/10.1111/j.1365-2133.2008.08628.x
  8. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115-26. https://doi.org/10.1056/NEJM199901143400207
  9. Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011; 12(5):3117-32. https://doi.org/10.3390/ijms12053117
  10. Berk M, Williams LJ, Jacka FN, et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013;11:200. https://doi.org/10.1186/1741-7015-11-200
  11. McArdle MA, Finucane OM, Connaughton RM, et al. Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne). 2013;4:52.
  12. Heymsfield SB, Wadden TA. Mechanisms, Pathophysiology, and Management of Obesity. N Engl J Med. 2017;376(15):1492.
  13. Liu C, Huang Y. Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action. Front Pharmacol. 2016;7:469.
  14. Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M. Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res. 2006;298(7):321-8. https://doi.org/10.1007/s00403-006-0703-z
  15. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol. 1995;32(6):982-6. https://doi.org/10.1016/0190-9622(95)91336-X
  16. Christophers E. Comorbidities in psoriasis. Clin Dermatol. 2007;25(6):529-34. https://doi.org/10.1016/j.clindermatol.2007.08.006
  17. Medzhitov R, Origin and physiological roles of inflammation. Nature. 2008; 454(7203):428-35. https://doi.org/10.1038/nature07201
  18. Rainer H. Straub, Carsten Schradin. Chronic inflammatory systemic diseases: An evolutionary trade-off betweenacutely beneficial but chronically harmful programs, Evol Med Public Health. 2016;2016(1):37-51.
  19. Netea MG, Balkwill F, Chonchol M, et al. A guiding map for inflammation. Nat Immunol. 2017;18(8):826-31. https://doi.org/10.1038/ni.3790
  20. Rapp SR, Feldman SR, Exum ML, Fleischer AB Jr, Reboussin DM. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol. 1999;41:401-7. https://doi.org/10.1016/S0190-9622(99)70112-X
  21. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(5):496-509. https://doi.org/10.1056/NEJMra0804595
  22. Parisi R, Symmons DP, Griffiths CE, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133(2):377-85. https://doi.org/10.1038/jid.2012.339
  23. Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 2017;31(2):205-12. https://doi.org/10.1111/jdv.13854
  24. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69:4-9. https://doi.org/10.1093/gerona/glu057
  25. Rousset L, Halioua B. Stress and psoriasis. Int J Dermatol. 2018;57(10):1165-172. https://doi.org/10.1111/ijd.14032
  26. Zachariae R, Zachariae H, Blomqvist K, et al. Self-reportedstress reactivity and psoriasis-related stress of nordic psoriasissufferers. J Eur Acad Dermatol Venereol. 2004;18(1):27-36. https://doi.org/10.1111/j.1468-3083.2004.00721.x
  27. Song H, Fang F, Tomasson G, et al. Association of Stress-Related Disorders With Subsequent Autoimmune Disease. JAMA. 2018;319(23):2388-400. https://doi.org/10.1001/jama.2018.7028
  28. Correia B, Torres T. Obesity: a key component of psoriasis. Acta Biomed. 2015;86(2):121-9.
  29. Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and metaanalysis of observational studies. Nutr Diabetes. 2012;2:e54. https://doi.org/10.1038/nutd.2012.26
  30. Dogra S, Mahajan R. Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring. Indian Dermatol Online J. 2016;7(6):471-80. https://doi.org/10.4103/2229-5178.193906
  31. Mason JC, Libby P. Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur Heart J. 2015;36(8):482-9c. https://doi.org/10.1093/eurheartj/ehu403
  32. Reich K, The concept of psoriasis as a systemic inflammation: implications for disease management. J Eur Acad Dermatol Venereol. 2012;26:3-11. https://doi.org/10.1111/j.1468-3083.2011.04410.x
  33. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001; 103(13):1813-8. https://doi.org/10.1161/01.CIR.103.13.1813
  34. Bassuk SS, Rifai N, Ridker PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol. 2004; 29(8):439-93. https://doi.org/10.1016/j.cpcardiol.2004.03.004
  35. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA. 2006;295(12):1412-9. https://doi.org/10.1001/jama.295.12.1412
  36. Strober B, Teller C, Yamauchi P, Miller JL, Hooper M, Yang YC, et al. Effects of etanercept on C-reactive protein levels in psoriasis and psoriatic arthritis. Br J Dermatol. 2008;159(2):322-30. https://doi.org/10.1111/j.1365-2133.2008.08628.x
  37. Sterry W, Strober BE, Menter A. Obesity in psoriasis: the metabolic, clinical and therapeutic implications. Report of an interdisciplinary conference and review. Br J Dermatol. 2007;157(4):649-55. https://doi.org/10.1111/j.1365-2133.2007.08068.x
  38. Vandevoorde V, Haegeman G, Fiers W. TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNFresistant L929 cells. FEBS Lett. 1992;302(3):235-8. https://doi.org/10.1016/0014-5793(92)80449-Q
  39. Naldi L, Peli L, Parazzini F. Association of Early-Stage Psoriasis With Smoking and Male Alcohol Consumption: evidence From an Italian Case-Control Study. Arch Dermatol. 1999;135(12):1479-84.
  40. Davidovici BB, Sattar N, Prinz J, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol. 2010;130(7):1785-96. https://doi.org/10.1038/jid.2010.103
  41. Ryan C, Kirby B. Psoriasis is a systemic disease with multiple cardiovascular and metabolic comorbidities. Dermatol Clin. 2015;33(1):41-55. https://doi.org/10.1016/j.det.2014.09.004
  42. Greb JE, Goldminz AM, Elder JT, et al. Psoriasis. Nat Rev Dis Primers. 2016;2:16082. https://doi.org/10.1038/nrdp.2016.82
  43. Meng S, Lin Z, Wang Y, Wang Z, Li P, Zheng Y. Psoriasis therapy by Chinese medicine and modern agents. Chin Med. 2018;13:16. https://doi.org/10.1186/s13020-018-0174-0
  44. Guan F, Lam W, Hu R, et al. Majority of Chinese Medicine Herb Category "Qing Re Yao" Have Multiple Mechanisms of Antiinflammatory Activity. Sci Rep. 2018;8(1):7416. https://doi.org/10.1038/s41598-018-25813-x
  45. Cheng H-M, Wu Y-C, Wang Q, et al. Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis. BMC Complement Altern Med. 2017;17(1):439. https://doi.org/10.1186/s12906-017-1947-1
  46. De Sa DC, Festa Neto C. Inflammasomes and dermatology. An Bras Dermatol. 2016;91(5):566-78. https://doi.org/10.1590/abd1806-4841.20165577
  47. Tozser J, Benko S. Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-$1{\beta}$ Production. Mediators Inflamm. 2016;2016:5460302.
  48. Lin X, Huang T, Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radic Res. 2016;50(6):585-95. https://doi.org/10.3109/10715762.2016.1162301
  49. Hirayama A, Oowada S, Ito H, et al. Clinical significance of redox effects of Kampo formulae, a traditional Japanese herbal medicine: comprehensive estimation of multiple antioxidative activities. J Clin Biochem Nutr. 2018;62(1):39-48.
  50. Wang D, Gu J, Zhu W, et al. PDTCM: a systems pharmacology platform of traditional Chinese medicine for psoriasis. Ann Med. 2017;49(8):652-60. https://doi.org/10.1080/07853890.2017.1364417
  51. Wu M, Deng Y, Li S, et al. The Immunoregulatory Effects of Traditional Chinese Medicine on Psoriasis via its Action on Interleukin: Advances and Considerations. Am J Chin Med. 2018;46(4):739-50. https://doi.org/10.1142/S0192415X18500386
  52. Lin YK, Chang YC, Hui RC, et al. A Chinese Herb, Indigo Naturalis, Extracted in Oil (Lindioil) Used Topically to Treat Psoriatic Nails: A Randomized Clinical Trial. JAMA Dermatol. 2015;151(6):672-4. https://doi.org/10.1001/jamadermatol.2014.5460
  53. Yan Y, Liu W, Andres P, et al. Exploratory clinical trial to evaluate the efficacy of a topical traditional chinese herbal medicine in psoriasis vulgaris. Evid Based Complement Alternat Med. 2015;2015:719641.
  54. Lin YK, See LC, Huang YH, Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double-blind, dosage-controlled trial. Br J Dermatol. 2018;178(1):124-31. https://doi.org/10.1111/bjd.15894
  55. Sun W, Gao Y, Yu X, et al. 'Psoriasis 1' reduces psoriasis-like skin inflammation by inhibiting the VDR-mediated nuclear NF-${\kappa}B$ and STAT signaling pathways. Mol Med Rep. 2018;18(3):2733-43.
  56. Lu C, Liu H, Jin X. Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells. Front Pharmacol. 2018;9:88. https://doi.org/10.3389/fphar.2018.00088
  57. Liu Q, Yin W, Han L, et al. Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited imiquimod-induced dendritic cells activation and Th1/Th17 differentiation. Int Immunopharmacol. 2018;56:339-48. https://doi.org/10.1016/j.intimp.2018.01.044
  58. Geng X, Shi H, Ye F, et al. Matrine inhibits itching by lowering the activity of calcium channel. Sci Rep. 2018;8(1):11328. https://doi.org/10.1038/s41598-018-28661-x
  59. Parker S, Zhang CS, Yu JJ, et al. Oral Chinese herbal medicine versus placebo for psoriasis vulgaris: A systematic review. J Dermatolog Treat. 2017;28(1):21-31. https://doi.org/10.1080/09546634.2016.1178377
  60. Zhang CS, Yang L, Zhang AL, et al. Is Oral Chinese Herbal Medicine Beneficial for Psoriasis Vulgaris? A Meta-Analysis of Comparisons with Acitretin. J Altern Complement Med. 2016;22(3):174-88. https://doi.org/10.1089/acm.2014.0212

Cited by

  1. 건선에 효과적인 한약 처방 탐색 - 지질 대사를 중심으로 vol.34, pp.3, 2018, https://doi.org/10.6114/jkood.2021.34.3.070