한국콘텐츠학회논문지 (The Journal of the Korea Contents Association)

  • 제19권11호
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  • Pages.424-433
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  • 2019
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  • 1598-4877(pISSN)
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  • 2508-6723(eISSN)
한국콘텐츠학회 (The Korea Contents Association)
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구강 내 자당 및 포도당 잔류 경과 시간에 따른 칼륨과 마그네슘 농도 변화

Survey on the Changes of Potassium and Magnesium Concentration according to the Retention Time After Rinse of Sucrose and Glucose in Oral

  • 이혜진 (동부산대학교 치위생과) ;
  • 양달님 (동부산대학교 치위생과)
  • 투고 : 2019.09.02
  • 심사 : 2019.10.04
  • 발행 : 2019.11.28
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초록

본 논문은 설탕물 양치 전후, 타액 내 칼륨과 마그네슘의 농도 변화를 분석한 연구이다. 타액 샘플은 10% 자당(포도당) 용액으로 양치하기 전과 양치 직후부터 60분까지 채취하였고 이온크로마토그래피법으로 분석하였다. 설탕물 양치 전 칼륨의 평균 농도는 274.3±77.9 mg/ℓ (279.2±62.1 mg/ℓ)이며, 마그네슘의 평균 농도는 4.5±2.5 mg/ℓ(4.8±2.0 mg/ℓ)이다. 설탕물 양치 직후, 칼륨과 마그네슘의 농도는 자당의 경우 143.9±55.4 mg/ℓ, 2.7±3.1 mg/ℓ이며, 포도당의 경우 150.9±64.2 mg/ℓ, 2.6±0.7 mg/ℓ로 대조군에 비해 급격히 낮아졌으나, 양치 후 60분에서 대조군의 이온 농도 수준으로 회복됨을 확인하였다. 즉 설탕물 양치 직후에는 자극에 의해 타액 내 칼륨과 마그네슘 이온 농도가 낮아지나, 60분 후에는 타액의 자정작용으로 구강 내 향상성이 회복되었다. 본 논문은 타액에 관한 기초자료를 축적하는 것에 의의를 두고 연구하였다.

The purpose of this study was to evaluate the salivary concentration of Potassium and Magnesium cations and their variation before and after sucrose and glucose rinse, and to investigate the relationship between the levels of each compound. Saliva samples were obtained from 40 subjects before and up to 60 min after intake of a 10% sucrose and glucose solution at 1-month intervals. Potassium and Magnesium in human saliva were determined via anion-exchange chromatography with an anion-suppressed conductivity detector using 12 mM sulfuric acid. The concentrations of Potassium and Magnesium before sucrose rinse were 274.3±77.9 mg/ℓ and 4.5±2.5 mg/ℓ, also, the concentrations of Potassium and Magnesium before glucose rinse were 279.2±62.1 mg/ and 4.8±2.0 mg/ℓ, respectively. Potassium and Magnesium concentrations were significantly decreased (p<0.05) after sucrose rinse. The content of potassium and magnesium in saliva before and after rinsing sucrose and glucose is difficult to standardize or classify, as previous research. The reason for the variation between individuals is large, and easily changed by chemical or physiological stimulation. However, this study was experiment for the purpose of accumulating basic data for saliva.

키워드

참고문헌

  1. 안구윤, 김보영, 이승원, 김경근, 박성식, "신장에서 칼륨 식이 변화에 따른 H/K-ATPase ${\alpha}$ Subunit($HK{\alpha}2a$, $HK{\alpha}2b$) 유전자 발현의 변화," 대한신장학회지, 제18권, 제5호, pp.672-682, 1999.
  2. B. B. Meyer, M. Y. Ibrahim, C. B. Bas, L. Cheval, S. Marsy, and A. Doucet, "K depletion modifies the properties of Sch 28080-sensitive K-ATPase in rat collecting duct," J. of American physiology, Vol.272, No.1, pp.124-131, 1997.
  3. 신경남, 이혜상, 권정숙, "제2형 당뇨환자에 대한 영양 교육이 당뇨병 관리와 혈액 항산화 상태에 미치는 영향," 한국식품영양과학회지, 제40권, 제5호, pp.689-695, 2011. https://doi.org/10.3746/jkfn.2011.40.5.689
  4. P. Newmark, "Events at the surface of the cell," J. of Nature, Vol.317, No.6036, p.380, 1985. https://doi.org/10.1038/317380a0
  5. I. L. Cameron, N. K. R. Smith, T. B. Pool, and R. L. Sparks, "Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo," J. of Cancer Research, Vol.40, pp.1493-1500, 1980.
  6. 조흔, 정지강, 김소영, 박건영, "칼륨죽염의 in vitro 항암 기능성 증진 효과," 한국식품영양과학회지, 제41권, 제9호, pp.1248-1252, 2012. https://doi.org/10.3746/jkfn.2012.41.9.1248
  7. I. Z. Nagy, G. Lustyik, G. Lukacs, V. Z. Nagy, and G. Balazs, "Correlation of malignancy with the intracellular Na+:K+ ratio in human thyroid tumors," J. of Cancer Research, Vol.43, No.11, pp.5395-5402, 1983.
  8. 임인석, "저칼륨혈증과 고칼륨혈증," 대한소아과학회지, 제49권, 제5호, pp.470-474, 2006.
  9. D. N. Zull, "Disorders of potassium metabolism," J. of the Emergency Medicine Clinics of North America, Vol.7, No.4, pp.771-865, 1989. https://doi.org/10.1016/S0733-8627(20)30316-3
  10. P. J. M. Tutton and D. H. Barkla, "The influence of dibutyryl adenosine cyclic monophosphate on cell proliferation in the epithelium of the jejunal crypts, the colonic crypts and colonic carcinoma of rat," J. of Clinical and Experimental Pharmacology and Physiology, Vol.7, pp.275-280, 1980. https://doi.org/10.1111/j.1440-1681.1980.tb00071.x
  11. J. D. Wilhelm, and M. Ketteler, "Magnesium basics," J. of Clinical Kidney, Vol.5, No.1, pp.3-14, 2012.
  12. I. Bodaker, I. Sharon, M. T. Suzuki, R. Feingersch, M. Shmoish, E. Andreishchev, M. L. Sogin, M. Rosenberg, M. E. Maguire, S. Belkin, A. Oren, and O. Beja, "Comparative community genomics in the Dead Sea: an increasingly extreme environment," J. of International Society for Microbial Ecology, Vol.4, No.3, pp.399-407, 2010.
  13. M. E. Maguire and J. A. Cowan, "Magnesium chemistry and biochemistry," J. of Biometals, Vol.15, No.3, pp.203-210, 2002. https://doi.org/10.1023/A:1016058229972
  14. H. Geiger and C. Wanner, "Magnesium in disease," J. of Clinical Kidney, Vol.5, No.1, pp.25-38, 2012.
  15. J. H. Baaij, J. G. Hoenderop, and R. J. Bindels, "Regulation of magnesium balance: lessons learned from human genetic disease," J. of Clinical Kidney, Vol.5, No.1, pp.15-24, 2012.
  16. D. M. Spiegel, "Magnesium in chronic kidney disease: unanswered questions," J. of Blood Purification, Vol.31, pp.172-176, 2011. https://doi.org/10.1159/000321837
  17. A. L. Fontaine, A. Zavgorodniy, H. Liu, R. Zheng, M. Swain, and J. Cairney, "Atomic-scale compositional mapping reveals Mg-rich amorphous calcium phosphate in human dental enamel," J. of science advances, Vol.2, No.9, pp.1-6, 2016.
  18. M. P. Levin, L. L. Yearwood, and W. N. Carpenter, "The desensitizing effect of calcium hydroxide and magnesium hydroxide on hypersensitive dentin," J. of oral surgery oral medicine oral pathology, Vol.35, No.5, pp.741-746, 1973. https://doi.org/10.1016/0030-4220(73)90044-3
  19. P. H. Keyes, "Present and future measures for dental caries control," J. of American Dental Association, Vol.79, No.6, pp.1395-1404, 1969. https://doi.org/10.14219/jada.archive.1969.0037
  20. Y. D. Park, J. H. Jang, Y. J. Oh, and H. J. Kwon, "Analyses of organic acids and inorganic anions and their relationship in human saliva before and after glucose intake," J. of Archives of Oral Biology, Vol.59, No.1, pp.1-11, 2014. https://doi.org/10.1016/j.archoralbio.2013.10.006
  21. S. M. Yoo and G. S. Ahn, "Correlation of Oral Microorganism and Carboxylic Acid in Oral Cavity," J. of International Journal of Clinical Preventive Dentistry, Vol.11, No.3, pp.165-170, 2015. https://doi.org/10.15236/ijcpd.2015.11.3.165
  22. 박정은, 황수연, 김설악, "칼슘 섭취 후 타액 내 칼슘 및 마그네슘 농도가 치아우식활성도에 미치는 영향," 한국치위생학회지, 제17권, 제2호, pp.283-294, 2017. https://doi.org/10.13065/jksdh.2017.17.02.283
  23. F. Guidozzi, M. Maclennan, K. M. Graham, and C. P. Jooste, "Salivary calcium, magnesium, phosphate, chloride, sodium and potassium in pregnancy and labour," J. of South African Medical, Vol.81, No.3, pp.152-156, 1992.
  24. T. Shpitzer, G. Bahar, R. Feinmesser, and R. M. Nagler, "A comprehensive salivary analysis for oral cancer diagnosis," J. of Cancer Research Clinical Oncology, Vol.133, No.9, pp.613-617, 2007. https://doi.org/10.1007/s00432-007-0207-z
  25. L. P. Carmen, "The role of saliva in maintaining oral health and as an aid to diagnosis," J. of Medicina Oral Patologia Oral Cirugia Bucal, Vol.11, No.5, pp. 449-455, 2006.
  26. C. Dawes, "Salivary flow patterns and the health of hard and soft oral tissues," J. of American dental association, Vol.139, pp.18-24, 2008. https://doi.org/10.14219/jada.archive.2008.0292
  27. M. Rabiei, I. S. Masooleh, E. K. Leyli, and L. R. Nikoukar, "Salivary calcium concentration as a screening tool for postmenopausal osteoporosis," J. of Rheumatic Diseases, Vol.16, No.2, pp.198-202, 2013. https://doi.org/10.1111/1756-185X.12003
  28. F. Guidozzi, M. Maclennan, K. M. Graham, and C. P. Jooste, "Salivary calcium, magnesium, phosphate, chloride, sodium and potassium in pregnancy and labour," J. of South African Medical, Vol.81, No.3, pp.152-154, 1992.
  29. J. R. Huizenga, A. Vissink, E. J. Kuipers, and C. H. Gips, "Helicobacter pylori and ammonia concentrations of whole, parotid and submandibular/ sublingual saliva," J. of Clinical Oral Investigations, Vol.3, No.2, pp.84-91, 1999. https://doi.org/10.1007/s007840050083
  30. J. R. Huizenga and C. H. Gips, "Determination of ammonia in saliva using indophenol, an ammonium electrode and an enzymatic method: A comparative investigation," J. of Clinical chemistry and clinical biochemistry, Vol.20, No.8, pp.571-575, 1982.
  31. I. L. Shannon and R. P. Feller, "Parotid saliva flow rate, calcium, phosphorus, and magnesium concentrations in relation to dental caries experience in children," J. of Pediatric Dentistry, Vol.1, No.1, pp.16-20, 1979.
  32. H. J. Gilfrich, H. J. Engel, and W. Prellwitz, "Magnesium concentration in saliva -- An indicator of digitalis toxicity," J. of Wiener Klinische Wochenschrift, Vol.59, No.12, pp.617-621, 1981. https://doi.org/10.1007/BF02593852
  33. N. Takahashi and T. Yamada, "Glucose and lactate metabolism by Actinomyces naeslundii," J. of Critical Reviews in Oral Biology and Medicine, Vol.10, No.4, pp.487-503, 1999. https://doi.org/10.1177/10454411990100040501
  34. 박정은, 장종화, "자당 및 탄산은료 섭취 후 생성되는 구강 내 치아우식 유발성 유기산의 농도 차이," 한국치위생학회지, 제17권, 제3호, pp.381-394, 2017. https://doi.org/10.13065/jksdh.2017.17.03.381