Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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The Effects of Acupuncture at LR3 Acupoint on Mitochondrial Complex IV Oxidase activity in Liver

태충 침자가 간 미토콘드리아 내 Complex IV에 미치는 영향

  • Choi, Donghee (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Lee, Yumi (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Kim, Mirae (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Park, Jeonghye (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Kim, Hyeran (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Na, Changsu (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Youn, Daehwan (Department of Acupoint & Meridian, College of Korean Medicine, Dongshin University)
  • 최동희 (동신대학교 한의과대학 경락경혈학교실) ;
  • 이유미 (동신대학교 한의과대학 경락경혈학교실) ;
  • 김미래 (동신대학교 한의과대학 경락경혈학교실) ;
  • 박정혜 (동신대학교 한의과대학 경락경혈학교실) ;
  • 김혜란 (동신대학교 한의과대학 경락경혈학교실) ;
  • 나창수 (동신대학교 한의과대학 경락경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경락경혈학교실)
  • Received : 2019.08.18
  • Accepted : 2019.09.26
  • Published : 2019.12.27
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Abstract

Objectives : The liver is rich in mitochondria and it plays a key role in whole-body energy homeostasis. Mitochondria is double membrane-bound organelle that supplies energy for intracellular metabolism including Krebs cycle and beta-oxidation. Acupuncture is known to stimulate and regulate the flow of energy. To explore the effect of acupuncture on the mitochondrial respiratory chain activity in the rats' livers, the activity of mitochondrial respiratory chain complexes I to IV was observed. Methods : The rats were divided into 4 groups; Normal 1 (no acupuncture treatment and anesthesia for 5 min), Normal 2 (no acupuncture treatment and anesthesia for 10 min), MA1 (acupuncture treatment at bilateral LR3 under anesthesia for 5 min), and MA2 (acupuncture treatment at bilateral LR3 under anesthesia for 10 min). All rats were sacrificed and the livers were examined for respiratory chain change. Results : There was no difference in ubiquinon oxidoreductase, succinate dehydrogenase, and ubiquinol cytochrome C oxidoreductase after acupuncture at LR3. Acupuncture at LR3 for 10 min increased the activity of cytochrome C oxidase compared with no acupuncture groups. Conclusions : Acupuncture at LR3 mediated mitochondrial respiratory chain activity via the cytochrome C oxidase signaling pathway in the livers of rats.

Keywords

References

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