Pediatric Infection and Vaccine

  • 제26권3호
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  • Pages.140-147
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  • 2019
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  • 2384-1079(pISSN)
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  • 2384-1087(eISSN)
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)
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소아 피부 및 연조직 감염 환자에서의 황색포도알균의 항생제 감수성의 변화: 2010년부터 2018년까지 단일기관에서의 경험

Changing Susceptibility of Staphylococcus aureus in Children with Skin and Soft Tissue Infections: a Single Center Experience from 2010 to 2018

  • 조용선 (차의과학대학교 분당차병원 소아청소년과) ;
  • 이신혜 (차의과학대학교 분당차병원 소아청소년과) ;
  • 이택진 (차의과학대학교 분당차병원 소아청소년과)
  • Cho, Yong-Sun (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Lee, Shin-Hye (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Lee, Taek-Jin (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine)
  • 투고 : 2019.07.05
  • 심사 : 2019.10.21
  • 발행 : 2019.12.25
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초록

목적: 피부 및 연조직 감염(skin and soft tissue infections [SSTIs])의 가장 흔한 원인은 황색포도알균(Staphylococcus aureus)이다. 본 연구는 19세 미만의 SSTI 환자에서 분리된 황색포도알균의 항생제 감수성의 변화추이를 알아보고자 하였다. 방법: 황색포도알균이 분리된 소아청소년 지역사회관련 SSTI 환자에서 후향적 관찰연구를 시행하였다. 미생물학 및 인구학적 자료를 수집하고, 항생제 감수성의 변화추이를 관찰하였다. 결과: 2010년 1월부터 2018년 12월까지 총 807개의 지역사회관련 황색포도알균이 연구에 포함되었다. Oxacillin에 대한 감수성은 전반적으로 증가하여(P<0.001) 2018년에는 75.0%였다. Trimethoprim/sulfamethoxazole과 tetracycline에 대한 감수성은 매우 높게 유지되어 2018년 각각 97.6%와 95.2%였다. 만 1-5세 연령군에서 만 6-18세 연령군에 비해 oxacillin 감수성이 유의하게 낮았다(53.4% vs. 75.0%, P<0.001). 결론: 소아청소년의 지역사회관련 SSTI의 원인이 된 황색포도알균 중 메티실린내성 황색포도알균의 비율이 감소하고 있는 것으로 보인다. 임상의는 경험적 항생제를 선택할 때 지역적 항생제 감수성 양상을 확인해야 한다.

Purpose: Staphylococcus aureus is a major cause of skin and soft tissue infections (SSTIs). This study aimed to determine the temporal trends in antibiotic susceptibility of S. aureus in SSTI patients aged <19 years. Methods: This retrospective observational study was conducted in pediatric patients with SSTI caused by community-associated S. aureus. Microbiologic and demographic data were collected, and the trends of antibiotic susceptibility results were evaluated. Results: From January 2010 to December 2018, a total of 807 S. aureus isolates were included. An overall increase in susceptibility of isolates to oxacillin was noted (P<0.001), with 75.0% of isolates being oxacillin-susceptible in 2018. S. aureus remained highly susceptible to trimethoprim/sulfamethoxazole and tetracycline, with 97.6% and 95.2% isolate susceptibility in 2018, respectively. Isolates from younger children aged 1 to 5 years had a significantly lower rate of susceptibility to oxacillin than older children aged 6 to 18 years (53.4% vs. 75.0%, P<0.001). Conclusions: The proportion of methicillin-resistant S. aureus isolates appears to decrease in pediatric patients with community-associated SSTI caused by S. aureus. Clinicians should be aware of regional susceptibility patterns when choosing empirical regimens.

키워드

참고문헌

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