Asian-Australasian Journal of Animal Sciences

  • 제32권2호
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  • Pages.192-200
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  • 2019
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Leukemia inhibitory factor and its receptor: expression and regulation in the porcine endometrium throughout the estrous cycle and pregnancy

  • Yoo, Inkyu (Department of Biological Science and Technology, Yonsei University) ;
  • Chae, Soogil (Department of Biological Science and Technology, Yonsei University) ;
  • Han, Jisoo (Department of Biological Science and Technology, Yonsei University) ;
  • Lee, Soohyung (Department of Biological Science and Technology, Yonsei University) ;
  • Kim, Hyun Jong (Dairy Science Division, National Institute of Animal Science, Rural Development Administration) ;
  • Ka, Hakhyun (Department of Biological Science and Technology, Yonsei University)
  • 투고 : 2018.06.07
  • 심사 : 2018.07.26
  • 발행 : 2019.02.01
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초록

Objective: Leukemia inhibitory factor (LIF) binds to a heterodimeric receptor composed of LIF receptor (LIFR) and glycoprotein 130 (GP130) to transmit signals into the cell. LIF plays an important role in reproduction by regulating immune response, decidualization, and implantation in several species. However, the expression of LIF and LIFR in the endometrium throughout the estrous cycle and pregnancy in pigs is not fully understood. Methods: We analyzed the expression of LIF and LIFR in the endometrium on days 0 (estrus), 3, 6, 9, 12, 15, and 18 of the estrous cycle, and days 12, 15, 30, 60, 90, and 114 of pregnancy, in conceptuses on days 12 and 15, and in chorioallantoic tissues on days 30, 60, 90, and 114 of pregnancy in pigs. We also determined the effects of estrogen and progesterone on the expression of LIF and LIFR in endometrial tissues. Results: The expression of LIF increased in the endometrium during the late diestrus phase of the estrous cycle and during mid- to late- pregnancy, while the expression of LIFR increased during early pregnancy. The expression of LIF was induced by increasing doses of estrogen, whereas the expression of LIFR was induced by increasing doses of progesterone. Conclusion: These results indicate that the expression of LIF and its receptor LIFR in the endometrium is regulated in a stage-specific manner during the estrous cycle and pregnancy, suggesting that LIF and its receptor signaling system may play critical roles in regulating endometrial function in pigs.

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참고문헌

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피인용 문헌

  1. Allogeneic Embryos Disregulate Leukemia Inhibitory Factor (LIF) and Its Receptor in the Porcine Endometrium During Implantation vol.7, 2019, https://doi.org/10.3389/fvets.2020.611598