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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Cellular senescence in cancer

  • Kim, Young Hwa (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) ;
  • Park, Tae Jun (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine)
  • Received : 2018.10.24
  • Published : 2019.01.31
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Abstract

Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy.

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References

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