Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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GS-KG9 ameliorates diabetic neuropathic pain induced by streptozotocin in rats

  • Lee, Jee Youn (Age-Related and Brain Diseases Research Center, Kyung Hee University) ;
  • Choi, Hae Young (Age-Related and Brain Diseases Research Center, Kyung Hee University) ;
  • Park, Chan Sol (KHU-KIST Department of Converging Science and Technology, Kyung Hee University) ;
  • Pyo, Mi Kyung (International Ginseng and Herb Research Institute) ;
  • Yune, Tae Young (Age-Related and Brain Diseases Research Center, Kyung Hee University) ;
  • Kim, Go Woon (Department of Pharmacology and Clinical Pharmacy, College of Pharmacy, Kyung Hee University) ;
  • Chung, Sung Hyun (Department of Pharmacology and Clinical Pharmacy, College of Pharmacy, Kyung Hee University)
  • Received : 2017.02.21
  • Accepted : 2017.08.07
  • Published : 2019.01.15
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Abstract

Background: Diabetic neuropathy is one of the most devastating ailments of the peripheral nervous system. Neuropathic pain develops in ~30% of diabetics. Here, we examined the suppressive effect of GS-KG9 on neuropathic pain induced by streptozotocin (STZ). Methods: Hyperglycemia was induced by intraperitoneal injection of STZ. Rats showing blood glucose level > 250 mg/dL were divided into five groups, and treatment groups received oral saline containing GS-KG9 (50 mg/kg, 150 mg/kg, or 300 mg/kg) twice daily for 4 wk. The effects of GS-KG9 on pain behavior, microglia activation in the lumbar spinal cord and ventral posterolateral (VPL) nucleus of the thalamus, and c-Fos expression in the dorsal horn of the lumbar spinal cord were examined. Results: The development of neuropathic pain began at Day 5 and peaked at Week 4 after STZ injection. Mechanical and thermal pains were both significantly attenuated in GS-KG9-treated groups from 10 d after STZ injection as compared to those in the STZ control. GS-KG9 also repressed microglia activation in L4 dorsal horn and VPL region of the thalamus. In addition, increase in c-Fos-positive cells within L4 dorsal horn lamina I and II of the STZ control group was markedly alleviated by GS-KG9. Conclusion: These results suggest that GS-KG9 effectively relieves STZ-induced neuropathic pain by inhibiting microglial activation in the spinal cord dorsal horn and VPL region of the thalamus.

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References

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