Imaging Science in Dentistry

Korean Academy of Oral and Maxillofacial Radiology (대한영상치의학회)
권호 표지
DOI QR코드

DOI QR Code

Delayed diagnosis of a primary intraosseous squamous cell carcinoma: A case report

  • Abdelkarim, Ahmed Z. (Department of Anatomy, Biochemistry and Physiology, University of Hawai'i School of Medicine) ;
  • Elzayat, Ahmed M. (Department of Oral and Maxillofacial Surgery, Insurance Hospital) ;
  • Syed, Ali Z. (Oral and Maxillofacial Medicine and Diagnostics Science, CWRU School of Dental Medicine) ;
  • Lozanoff, Scott (Department of Anatomy, Biochemistry and Physiology, University of Hawai'i School of Medicine)
  • Received : 2018.08.26
  • Accepted : 2018.11.18
  • Published : 2019.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Primary intraosseous squamous cell carcinoma is a rare malignant central jaw tumor derived from odontogenic epithelial remnants. Predominantly, it affects mandible, although both jaw bones may be involved. This report describes a 60-year-old man who was initially misdiagnosed with a periapical infection related to the right lower wisdom tooth. After four months, the patient presented to a private dental clinic with a massive swelling at the right side of the mandible. Panoramic radiographs and advanced imaging revealed a lesion with complete erosion of the right ramus, which extended to the orbital floor. A biopsy from the mandibular angle revealed large pleomorphic atypical squamous cells, which is the primary microscopic feature of a poorly differentiated squamous cell carcinoma.

Keywords

References

  1. Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Oral Pathol Med 2011; 40: 733-8. https://doi.org/10.1111/j.1600-0714.2011.01058.x
  2. Williams MD. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Mucosal Melanomas. Head Neck Pathol 2017; 11: 110-7. https://doi.org/10.1007/s12105-017-0789-y
  3. Matsuzaki H, Katase N, Matsumura T, Hara M, Yanagi Y, Nagatsuka H, et al. Solid-type primary intraosseous squamous cell carcinoma of the mandible: a case report with histopathological and imaging features. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114: e71-7.
  4. Suei Y, Tanimoto K, Taguchi A, Wada T. Primary intraosseous carcinoma: review of the literature and diagnostic criteria. J Oral Maxillofac Surg 1994; 52: 580-3. https://doi.org/10.1016/0278-2391(94)90094-9
  5. Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis JS Jr, Rinaldo A, et al. Intraosseous carcinoma of the jaws: a clinicopathologic review. Part II: odontogenic carcinomas. Head Neck 2013; 35: 902-5. https://doi.org/10.1002/hed.22923
  6. Sengupta S, Vij H, Vij R. Primary intraosseous carcinoma of the mandible: a report of two cases. J Oral Maxillofac Pathol 2010; 14: 69-72. https://doi.org/10.4103/0973-029X.72504
  7. Thakur A, Tupkari JV, Joy T, Gogri AA. Primary intraosseous squamous cell carcinoma-a rare odontogenic malignancy. J Oral Maxillofac Pathol 2017; 21: 320.
  8. Tawfik MA, Zyada MM. Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e67-73. https://doi.org/10.1016/j.tripleo.2009.09.003
  9. Huang JW, Luo HY, Li Q, Li TJ. Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors. Arch Pathol Lab Med 2009; 133: 1834-40. https://doi.org/10.5858/133.11.1834
  10. Thomas G, Pandey M, Mathew A, Abraham EK, Francis A, Somanathan T, et al. Primary intraosseous carcinoma of the jaw: pooled analysis of world literature and report of two new cases. Int J Oral Maxillofac Surg 2001; 30: 349-55. https://doi.org/10.1054/ijom.2001.0069
  11. Suei Y, Taguchi A, Tanimoto K. Recommendation of modified classification for odontogenic carcinomas. Med Hypotheses 2004; 62: 382-6. https://doi.org/10.1016/j.mehy.2003.11.010
  12. Elzay RP. Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol 1982; 54: 299-303. https://doi.org/10.1016/0030-4220(82)90099-8
  13. Reichart P, Philipsen HP. Odontogenic tumors and allied lesions. London: Quintessence Pub; 2004. p. 205-25.
  14. Dai YL, King AD. State of the art MRI in head and neck cancer. Clin Radiol 2018; 73: 45-59. https://doi.org/10.1016/j.crad.2017.05.020
  15. Grisar K, Schol M, Hauben E, Schoenaers J, Politis C. Primary intraosseous squamous cell carcinoma of the mandible arising from an infected odontogenic cyst: a case report and review of the literature. Oncol Lett 2016; 12: 5327-31. https://doi.org/10.3892/ol.2016.5378
  16. Slootweg PJ, Muller H. Malignant ameloblastoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol 1984; 57:168-76. https://doi.org/10.1016/0030-4220(84)90207-X
  17. Waldron CA, Mustoe TA. Primary intraosseous carcinoma of the mandible with probable origin in an odontogenic cyst. Oral Surg Oral Med Oral Pathol 1989; 67: 716-24. https://doi.org/10.1016/0030-4220(89)90014-5

Cited by

  1. Reduced delay in diagnosis of odontogenic keratocysts with malignant transformation: A case report vol.8, pp.11, 2020, https://doi.org/10.12998/wjcc.v8.i11.2374
  2. Primary nonkeratinizing squamous cell carcinoma of the scapular bone: A case report vol.9, pp.4, 2021, https://doi.org/10.12998/wjcc.v9.i4.976