Korean Journal of Acupuncture

  • 제36권1호
  • /
  • Pages.63-73
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  • 2019
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  • 2287-3368(pISSN)
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  • 2287-3376(eISSN)
경락경혈학회 (Society for Meridian and Acupoint)
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신수(BL23) 택사약침이 Cisplatin으로 유발된 급성신부전 백서에 미치는 영향

Effects of Alismatis Rhizoma Pharmacopuncture at BL23 on Cisplatin-Induced Acute Renal Failure in Rats

  • 김명식 (동신대학교 한의과대학 침구의학교실) ;
  • 김재홍 (동신대학교 한의과대학 침구의학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실) ;
  • 조명래 (동신대학교 한의과대학 침구의학교실)
  • Kim, Myung Sik (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Kim, Jae Hong (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Youn, Dae Hwan (Department of Meridian & Acupoint, College of Korean Medicine, Dongshin University) ;
  • Jeong, Hyun Woo (Department of Pathology, College of Korean Medicine, Dongshin University) ;
  • Cho, Myoung Rae (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dongshin University)
  • 투고 : 2019.02.21
  • 심사 : 2019.03.11
  • 발행 : 2019.03.27
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초록

Objectives : This study was designed to investigate the effects of Alismatis Rhizoma (AR) pharmacopuncture at BL23 on acute renal failure induced by cisplatin. Methods : The Sprague-Dawley rats were divided into Normal group (no injection of cisplatin and no treatment), Control group (cisplatin injection without treatment), Acu group (needling at BL23 after cisplatin injection), AR-PA1 group (treated with $0.3571mg/kg/20{\mu}l$ of AR pharmacopuncture at BL23 after cisplatin injection), and AR-PA2 group (treated with $1.7855mg/kg/20{\mu}l$ of AR pharmacopuncture at BL23 after cisplatin injection). Each treatment was given once daily for 8 days. Changes in body weight, kidney weight, tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin-6 (IL-6), Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GPx), serum blood urea nitrogen (serum BUN), and serum creatinine were observed. Results : Body weight was significantly increased in AR-PA1 on $4^{th}$ and $6^{th}$ days and AR-PA2 on $2^{nd}$ day. $TNF-{\alpha}$ was significantly decreased in Acu, AR-PA1 and AR-PA2 groups. Cu-Zn SOD was significantly increased in AR-PA2 group. GPx was significantly increased in AR-PA1 and AR-PA2 groups. But kidney weight, IL-6, serum BUN and serum creatinine were not significantly changed in any groups compared to control group. Conclusions : In acute renal failure induced by cisplatin, AR pharmacopuncture has a mitigating effect on the inflammatory reaction related to the increase of $TNF-{\alpha}$ in the kidney tissue and a protective effect on the oxidative stress of the kidney tissue. However it is unlikely to restore the glomerular function or inhibit the renal swelling.

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