Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

  • Wang, Lijun (Department of Cardiology, Affiliated Zhongshan Hospital, Dalian University) ;
  • Zhou, Baihua (Department of Cardiology, Affiliated Zhongshan Hospital, Dalian University) ;
  • Zhou, Xue (Department of Laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing Second Hospital) ;
  • Wang, Yang (Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Wang, Hongwei (Department of Cardiology, Affiliated Zhongshan Hospital, Dalian University) ;
  • Jia, Shengying (Department of Cardiology, Affiliated Zhongshan Hospital, Dalian University) ;
  • Zhang, Zhipeng (Department of Cardiology, Affiliated Zhongshan Hospital, Dalian University) ;
  • Chu, Chao (Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University) ;
  • Mu, Jianjun (Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University)
  • Received : 2018.06.04
  • Accepted : 2018.10.30
  • Published : 2019.03.28
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Abstract

Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.

Keywords

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