Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-thrombosis Activities of the Root Extract of Moringa oleifera Lam

모링가 지하부의 항혈전 활성

  • Kwon, Chong Suk (Department of Food and Nutrition, Andong National University) ;
  • Sung, Hwa-Jung (Department of Food and Nutrition, Andong National University) ;
  • Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
  • Received : 2018.07.03
  • Accepted : 2018.08.21
  • Published : 2019.03.28
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Abstract

Moringa oleifera Lam (MOL) has been used as a traditional medicine to treat various cancers and inflammation. Whereas the bioactivities of the MOL leaf and seed are well reported, the study of the root is still rudimentary. In this study, the ethanol extract of MOL (EEMOL) and its subsequent organic solvent fractions were prepared and their anticoagulation activity in vitro and platelet aggregation inhibitory activity were evaluated. The EEMOL had negligible anticoagulation and strong platelet aggregation activities. However, the hexane and ethyl acetate fractions of EEMOL showed significant inhibition against thrombin, prothrombin, coagulation factors, and platelet aggregation, without hemolytic activity up to 1.0 mg/ml. Our results suggest that the active fractions of MOL root have potential as new anti-thrombosis agents.

열매, 잎, 꽃, 봉우리, 꼬투리 등의 지상부를 약용 및 식용으로 사용하고 있는 모링가는 miracle tree라고 불리고 있다. 그러나, 현재까지 주로 잎과 씨에 대한 연구가 진행된 바, 지하부에 대한 성분 및 효능 연구는 초보적인 상태이다. 본 연구에서는 모링가 지하부의 유용 생리활성을 평가하기 위해 지하부의 ethanol 추출물 및 이의 순차적 유기 용매 분획물을 조제하고 이의 혈액응고 저해 및 혈소판 응집저해 활성을 평가하였다. 그 결과, 모링가 지하부 ethanol 추출물은 항응고 활성이 미약하고, 혈소판 응집 촉진효과를 나타내어 지혈작용을 나타내었으나, 추출물의 hexane 및 ethylacetate 분획에서는 우수한 트롬빈, 프로트롬빈, 혈액응고인자 저해와 함께 혈소판 응집저해 활성을 나타내었다. 또한 모링가 지하부 추출물 및 분획물들은 1.0 mg/ml 농도까지 인간 적혈구 용혈활성이 없음을 확인하여, 상기 분획물들이 신규의 항혈전제로 사용 가능함을 제시하였다.

Keywords

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