Journal of dental hygiene science (치위생과학회지)

The Korean Society of Dental Hygiene Science (한국치위생과학회)
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Preventive Effects of Fluoride Gel Application on Dental Caries in the Permanent Tooth: A Systematic Review of Randomized Controlled Trials

  • Do, Kyung-Yi (Department of Public Health, Graduate School, The Catholic University of Korea) ;
  • Lee, Eun-Sun (Department of Dental Hygiene, Kyungbok University)
  • Received : 2018.10.22
  • Accepted : 2018.11.28
  • Published : 2019.03.31
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Abstract

Background: The purpose of this systematic review was to investigate the effects of topical fluoride gel application on dental caries prevention in the permanent teeth of children and adolescents. Methods: We searched the EMBASE, PubMed, and Cochrane Library databases for randomized controlled trials (RCTs) assessing the effects of self-applied or professionally applied topical fluoride gels in patients <18 years of age; the search was completed on April 1, 2018. All included trials involved an experimental group (fluoride gel application) and a control group (placebo or no treatment). The outcome measures were the D(M)FS and D(M)FT indices, which were compared between the two groups. Review Manager software was used for quantitative synthesis of the final selected articles, and a forest plot was generated via a meta-analysis conducted using a random effects model. Results: The results showed that the D(M)FS and D(M)FT indices were lower in the fluoride application group than in the control group, thus indicating that fluoride gel application was effective in dental caries prevention. We also performed a subgroup analysis to determine whether the effects of fluoride application differed if patients received oral prophylaxis (self or professional) before fluoride gel application. Therefore, the two groups showed slightly larger differences when studies without oral prophylaxis before fluoride gel application were considered; however, the difference was not statistically significant. Conclusion: These findings should be utilized to raise awareness about the caries-prevention effects of topical fluoride application among patients and guardians. Further RCTs should evaluate the effects of fluoride application with or without preceding oral prophylaxis, and appropriate fluoride application guidelines should be developed to maximize the effects of fluoride application in clinical practice.

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References

  1. Marinho VC, Worthington HV, Walsh T, Chong LY: Fluoride gels for preventing dental caries in children and adolescents. Cochrane Database Syst Rev (6): CD002280, 2015. https://doi.org/10.1002/14651858.CD002280
  2. Truin GJ, van't Hof MA: Professionally applied fluoride gel in low-caries 10.5-year-olds. J Dent Res 84: 418-421, 2005. https://doi.org/10.1177/154405910508400504
  3. ten Cate JM: Current concepts on the theories of the mechanism of action of fluoride. Acta Odontol Scand 57:325-329, 1999. https://doi.org/10.1080/000163599428562
  4. Jung EY, Kim MJ, Kim YJ, et al.: Associated factors of the approval for the community water fluoridation program. J Dent Hyg Sci 13: 29-35, 2013.
  5. van Rijkom HM, Truin GJ, van 't Hof MA: Caries-inhibiting effect of professional fluoride gel application in low-caries children initially aged 4.5-6.5 years. Caries Res 38: 115-123, 2004. https://doi.org/10.1159/000075935
  6. Bonow ML, Azevedo MS, Goettems ML, Rodrigues CR: Efficacy of 1.23% APF gel applications on incipient carious lesions: a double-blind randomized clinical trial. Braz Oral Res 27: 279-285, 2013. https://doi.org/10.1590/S1806-83242013000300007
  7. Agrawal N, Pushpanjali K: Feasibility of including APF gel application in a school oral health promotion program as a caries-preventive agent: a community intervention trial. J Oral Sci 53: 185-191, 2011. https://doi.org/10.2334/josnusd.53.185
  8. DePaola PF, Soparkar M, Van Leeuwen M, DeVelis R: The anticaries effect of single and combined topical fluoride systems in school children. Arch Oral Biol 25: 649-653, 1980. https://doi.org/10.1016/0003-9969(80)90095-3
  9. Jiang H, Tai B, Du M, Peng B: Effect of professional application of APF foam on caries reduction in permanent first molars in 6-7-year-old children: 24-month clinical trial. J Dent 33: 469-473, 2005. https://doi.org/10.1016/j.jdent.2004.10.023
  10. Mainwaring PJ, Naylor MN: A three-year clinical study to determine the separate and combined caries-inhibiting effects of sodium monofluorophosphate toothpaste and an acidulated phosphate-fluoride gel. Caries Res 12: 202-212, 1978. https://doi.org/10.1159/000260334
  11. Splieth CH, Berndt C, Alkilzy M, Treuner A: Efficacy of semiannual topical fluoride application in schoolchildren. Quintessence Int 42: 753-760, 2011.
  12. Englander HR, Sherrill LT, Miller BG, Carlos JP, Mellberg JR, Senning RS: Incremental rates of dental caries after repeated topical sodium fluoride applications in children with lifelong consumption of fluoridated water. J Am Dent Assoc 82: 354-358, 1971. https://doi.org/10.14219/jada.archive.1971.0042
  13. Olivier M, Brodeur JM, Simard PL: Efficacy of APF treatments without prior toothcleaning targeted to high-risk children. Community Dent Oral Epidemiol 20: 38-42, 1992. https://doi.org/10.1111/j.1600-0528.1992.tb00671.x
  14. Shern RJ, Duany LF, Senning RS, Zinner DD: Clinical study of an amine fluoride gel and acidulated phosphate fluoride gel. Community Dent Oral Epidemiol 4: 133-136, 1976. https://doi.org/10.1111/j.1600-0528.1976.tb00969.x
  15. Bryan ET, Williams JE: The cariostatic effectiveness of a phosphate-fluoride gel administered annually to school children; final results. J Public Health Dent 30: 13-16, 1970. https://doi.org/10.1111/j.1752-7325.1970.tb00531.x
  16. Cons NC, Janerich DT, Senning RS: Albany topical fluoride study. J Am Dent Assoc 80: 777-781, 1970. https://doi.org/10.14219/jada.archive.1970.0113
  17. Hagan PP, Rozier RG, Bawden JW: The caries-preventive effects of full- and half-strength topical acidulated phosphate fluoride. Pediatr Dent 7: 185-191, 1985.
  18. Horowitz HS, Doyle J: The effect on dental caries of topically applied acidulated phosphate-fluoride: results after three years. J Am Dent Assoc 82: 359-365, 1971. https://doi.org/10.14219/jada.archive.1971.0063
  19. Trubman A, Crellin JA: Effect on dental caries of self-application of acidulated phosphate fluoride paste and gel. J Am Dent Assoc 86: 153-157, 1973. https://doi.org/10.1016/S0002-8177(73)61038-0
  20. Englander HR, Carlos JP, Senning RS, Mellberg JR: Residual anticaries effect of repeated topical sodium fluoride applications by mouthpieces. J Am Dent Assoc 78: 783-787, 1969. https://doi.org/10.1016/S0002-8177(69)84025-0
  21. Vrbic V, Kosmelj B, Ravnik C: A 3-year study among Yugoslavian schoolchildren on caries reduction after topical application of 4% NaF-PO4. Community Dent Oral Epidemiol 2: 163-165, 1974. https://doi.org/10.1111/j.1600-0528.1974.tb01868.x
  22. Higgins JP, Altman DG, Gøtzsche PC, et al.: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343: d5928, 2011. https://doi.org/10.1136/bmj.d5928
  23. Do KY, Lee ES, Lee KS: Association between excessive Internet use and oral health behaviors of Korean adolescents: a 2015 national survey. Community Dent Health 34: 183-189, 2017. https://doi.org/10.1922/CDH_4107Do07
  24. Ferreira MA, Latorre Mdo R, Rodrigues CS, Lima KC: Effect of regular fluoride gel application on incipient carious lesions. Oral Health Prev Dent 3: 141-149, 2005.
  25. Do KY: Impact of health risk factors on the oral health of Korean adolescents: Korea youth risk behavior web-based survey, 2013. J Dent Hyg Sci 16: 193-199, 2016. https://doi.org/10.17135/jdhs.2016.16.3.193
  26. Miller FY, Campus G, Giuliana G, Piscopo MR, Pizzo G: Topical fluoride for preventing dental caries in children and adolescents. Curr Pharm Des 18: 5532-5541, 2012. https://doi.org/10.2174/138161212803307464
  27. Jang SO, Choi EM, Oh SH, Kang MK, Kim KM: The surface characteristics of enamel according to fluoride application methods and frequency. J Dent Hyg Sci 11: 69-76, 2011.
  28. O'Mullane DM, Baez RJ, Jones S, et al.: Fluoride and oral health. Community Dent Health 33: 69-99, 2016.
  29. Stokes E, Ashcroft A, Burnside G, Mohindra T, Pine CM: Randomised controlled trial of the efficacy of a high-fluoride gel self-applied by toothbrushing in children at high caries risk. Caries Res 45: 475-485, 2011. https://doi.org/10.1159/000331205
  30. Si Y, Guo Y, Yuan C, Xu T, Zheng SG: Comprehensive oral health care to reduce the incidence of severe early childhood caries (s-ECC) in urban China. Chin J Dent Res 19: 55-63, 2016. https://doi.org/10.3290/j.cjdr.a35698
  31. Marthaler TM, Konig KG, Muhlemann HR: The effect of a fluoride gel used for supervised toothbrushing 15 or 30 times per year. Helv Odontol Acta 14: 67-77, 1970.
  32. Treide A, Treide B: [Caries limiting effectiveness of newly developed fluoride-containing gels after 3 years clinical use in preschool years]. Stomatol DDR 38: 708-712, 1988.
  33. Jiang H, Bian Z, Tai BJ, Du MQ, Peng B: The effect of a bi-annual professional application of APF foam on dental caries increment in primary teeth: 24-month clinical trial. J Dent Res 84: 265-268, 2005. https://doi.org/10.1177/154405910508400311
  34. Andruskeviciene V, Milciuviene S, Bendoraitiene E, et al.: Oral health status and effectiveness of caries prevention programme in kindergartens in Kaunas city (Lithuania). Oral Health Prev Dent 6: 343-348, 2008.
  35. Maguire A: ADA clinical recommendations on topical fluoride for caries prevention. Evid Based Dent 15: 38-39, 2014. https://doi.org/10.1038/sj.ebd.6401019
  36. Gao SS, Zhang S, Mei ML, Lo EC, Chu CH: Caries remineralisation and arresting effect in children by professionally applied fluoride treatment: a systematic review. BMC Oral Health 16: 12, 2016. https://doi.org/10.1186/s12903-016-0171-6